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What are the dangers of mixing antipsychotics & alcohol?

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My boyfriend is taking both Zyprexa and Seroquel simultaneously to treat the symptoms of his disorder. However, he continues to drink alcohol while on these medications. I have read up on both of them, and both say not to consume alcohol while taking either; nevermind both together… I understand that drinking while on these medications can emphasize the affects of the alcohol. What I want to know is: What is the worst case scenario of his continued drinking while on these medications? He is in danger of relapse, or alcohol poisoning? Any help would be greatly appreciated.

What are the dangers of mixing antipsychotics & alcohol?

Answered by on -


I cannot say specifically what could happen to your boyfriend if he continues to drink while taking antipsychotic medications. But I do know that it is extremely unhealthy and dangerous.

First, his continued use of alcohol can increase and enhance his psychotic symptoms. Second, the alcohol can inhibit the ability of the medications to work properly. Lastly, there is a considerable danger in using alcohol with any prescription drugs, and this is especially true with Zyprexa and Seroquel. These are two medications that already have considerable side effects and can cause heavy sedation. Mixing them with alcohol may only increase that sedation. cites common side effects that can occur due to mixing prescription drugs with alcohol. They include:

  • Behavioral and emotional changes
  • Stomach upset, nausea, or vomiting
  • Headaches
  • Drowsiness, fatigue, or excessive sleep
  • Fainting/dizziness
  • Blood pressure changes or heart damage
  • Trouble with coordination, causing accidents


According to, “Antipsychotics are a large class of medications used to treat symptoms of psychosis such as delusions (for example, hearing voices), hallucinations, paranoia, or confused thoughts. They are used for other mental health disorders as well. They work by changing the balances of chemicals in the brain. Antipsychotics have central nervous system (CNS) depressive properties and should not be used in combination with alcohol due to the additive effects. The combination of antipsychotics and alcohol can increase sedation, respiratory depression, result in poor decision making or cognitive impairment, lead to low blood pressure (hypotension), and put patients at risk for a fall and injury.”

If you mix a prescription drug with alcohol, either by accident or specifically to get high, there is a high risk of overdose or damage to the body.

Specifically with Olanzapine (Zyprexa), NAMI, on its website, states, “Avoid drinking alcohol or using illegal drugs while you are taking olanzapine. They may decrease the benefits (e.g. worsen your confusion) and increase adverse effects (e.g. sedation) of the medication.”

Livestrong’s website quotes AstraZeneca (the biopharmaceutical company that makes Seroquel), who state that “ingesting alcohol with Seroquel may cause alcohol intolerance. This means a person drinking alcohol and taking Seroquel at the same time may feel the effects of alcohol more acutely than usual.” Additionally, AstraZeneca conducted a clinical trial and concluded that “Seroquel caused people to have diminished motor control, and they were not as coordinated at operating machinery when under the influence of the medication. The clinical trial showed that mixing alcohol and Seroquel together made coordination worse.”

I cannot give you a worst case scenario, per se, but I can assure you that nothing good can result from mixing medications and alcohol. Taking antipsychotic drugs and alcohol together can potentially lead to liver damage. It is extremely dangerous, not only for his physical health but there is a definite chance of illness relapse with this type of continued behavior. Make sure you do whatever you can to put a stop to his behavior. As one project website says, “Chronic polysubstance abuse can, over time, lead to deteriorations of your physical and mental health, negatively affect your relationships, drain your finances, and decrease your performance at school or work.” You might consider calling his doctor or therapist to inform them of his alcohol abuse while using antipsychotics. It may be the only way to put a stop to his harmful behavior. Take care.

What are the dangers of mixing antipsychotics & alcohol?

This article has been updated from the original version, which was originally published here on April 30, 2007.

Therapists live, online right now, from BetterHelp:

Kristina Randle, Ph.D., LCSW

Kristina Randle, Ph.D., LCSW is a licensed psychotherapist and Assistant Professor of Social Work and Forensics with extensive experience in the field of mental health. She works in private practice with adults, adolescents and families. Kristina has worked in a large array of settings including community mental health, college counseling and university research centers.

APA Reference
Randle, K. (2019). What are the dangers of mixing antipsychotics & alcohol?. Psych Central. Retrieved on November 28, 2020, from
Scientifically Reviewed
Last updated: 9 May 2019 (Originally: 30 Apr 2017)
Last reviewed: By a member of our scientific advisory board on 9 May 2019
Published on Psych All rights reserved.