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Do I Have Treatment-Resistant Depression?

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What else should I try? I am a 21-year-old college student and have been depressed for most (if not all of) my life. I was formally diagnosed with dysthymic disorder depression in high school and have since struggled a bit with eating disorders, anxiety, and panic disorders. I have also had several medical problems, most likely relating to depression and anxiety, including gastrointestinal problems and migraines. So far, I have seen 4 different psychologists and 2 psychiatrists as well as countless other medical professionals. I have been on Celexa, Wellbutrin (SR and XL), Abilify, Remeron, Lexapro, Zoloft, Xanax, and most recently Pristiq. So far, nothing seems to be working and the side effects of the meds far outweigh any benefits I might be getting. Is it possible I have treatment or medication-resistant depression? What else is out there to try aside from medications and psychotherapy?

Do I Have Treatment-Resistant Depression?

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You may have treatment-resistant depression but the more likely problem stems from not having met the right therapist or found the right combination of medication. I always encourage individuals to try at least five to 10 therapists. In your case, you may have to interview 15 or 20 therapists. Don’t stop until you find the one who will be most helpful to you.

Don’t be discouraged. It can and often does take a long time to find good help. It is important to be patient and thorough. Not all therapists are created equally. Interview as many as possible and further investigate the ones who seem promising. Follow the same process with psychiatrists. In addition, try to find a psychiatrist who is willing to work with you to find the best combination of medications.

In the meantime, you may want to try other types of treatment including group therapy. You may also benefit from a specialized form of treatment such as dialectical behavioral therapy. Marsha Linehan, the developer of DBT, recently wrote an interesting article for the New York Times. She discusses her own personal life struggles and how they ultimately led her to the development of DBT. I would encourage you to read her article.

Other ideas include reading self-help books. Some books you may want to start with include: The Road Less Traveled by M. Scott Peck; Man’s Search for Meaning by Viktor Frankl; and My Stroke of Insight by Jill Bolte Taylor. You can read reviews of those books and many others on Amazon or Barnes &

Electroconvulsive therapy is often the treatment of last resort. You could explore ECT. Start with reading detailed accounts from those who have undergone the treatment. You should also review the most recent ECT research. Generally speaking, you should explore all treatment possibilities.

I hope this helps. I know it is difficult to find the right help. It takes time, perseverance and patience. I wish you the best of luck. Please take care.

Dr. Kristina Randle

Do I Have Treatment-Resistant Depression?

Therapists live, online right now, from BetterHelp:

Kristina Randle, Ph.D., LCSW

Kristina Randle, Ph.D., LCSW is a licensed psychotherapist and Assistant Professor of Social Work and Forensics with extensive experience in the field of mental health. She works in private practice with adults, adolescents and families. Kristina has worked in a large array of settings including community mental health, college counseling and university research centers.

APA Reference
Randle, K. (2018). Do I Have Treatment-Resistant Depression?. Psych Central. Retrieved on October 21, 2020, from
Scientifically Reviewed
Last updated: 8 May 2018 (Originally: 20 Jul 2011)
Last reviewed: By a member of our scientific advisory board on 8 May 2018
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