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What are the dangers of mixing antipsychotics and alcohol?

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Q. He is taking both Zyprexa and Seroquel simultaneously to treat the symptoms of his disorder. However, he continues to drink alcohol while on these medications. I have read up on both of them, and both say not to consume alcohol while taking either; nevermind both together… I understand that drinking while on these medications can emphasize the affects of the alcohol. What I want to know is: What is the worst case scenario of his continued drinking while on these medications? He is in danger of relapse, or alcohol poisoning? Any help would be greatly appreciated.

What are the dangers of mixing antipsychotics and alcohol?

Answered by on -


I cannot say specifically what could happen to your boyfriend if he continues to drink while taking antipsychotic medications. But I do know that it is extremely unhealthy and dangerous. First, his continued use of alcohol can increase his psychotic symptoms. Second, the alcohol can inhibit the ability of the medications to work properly. Lastly, there is a considerable danger in using alcohol with any prescription drugs, and this is especially true with Zyprexa and Seroquel, two medications that already have considerable side effects and can cause heavy sedation. Mixing them with alcohol may only increase that sedation. I cannot give you a worst case scenario per say but I can say that nothing good can result from mixing medications and alcohol. It is extremely dangerous, not only for his physical health but there is a definite chance of illness relapse with his continued behavior. Do what you can to put a stop to his behavior. Consider calling his doctor or therapist to inform them of his alcohol abuse while using antipsychotics. It may be the only way to put a stop to his harmful behavior. Take care.

What are the dangers of mixing antipsychotics and alcohol?

Kristina Randle, Ph.D., LCSW

Kristina Randle, Ph.D., LCSW is a licensed psychotherapist and Assistant Professor of Social Work and Forensics with extensive experience in the field of mental health. She works in private practice with adults, adolescents and families. Kristina has worked in a large array of settings including community mental health, college counseling and university research centers.

APA Reference
Randle, K. (2018). What are the dangers of mixing antipsychotics and alcohol?. Psych Central. Retrieved on March 26, 2019, from
Scientifically Reviewed
Last updated: 8 May 2018
Last reviewed: By a member of our scientific advisory board on 8 May 2018
Published on Psych All rights reserved.