Exposures to the insecticide chlorpyrifos in pregnancy adversely affect child development

Peer-reviewed study funded by EPA and National Institutes of Health is first to reveal link between neurobehavioral deficits and prenatal exposure to common agricultural insecticide

Children who were exposed prenatally to the insecticide chlorpyrifos had significantly poorer mental and motor development by three years of age and increased risk for behavior problems, according to a peer-reviewed study published today by the American Academy of Pediatrics in its journal, Pediatrics. Chlorpyrifos, which was banned for residential use in 2001, is still widely applied to agricultural crops in the U.S. and abroad, including many fruits and vegetables.

The study assessed development of approximately 250 inner-city children from New York City who were born between 1998 and 2002. By age three, the children with the highest levels of chlorpyrifos at birth (upper 20th percentile) had significantly worse mental development and poorer motor skills than children with lower exposure levels. The more highly exposed children were also more likely by age three to exhibit early indications of behavior and attention problems. The study was co-authored by researchers from the Columbia Center for Children's Environmental Health at Columbia University's Mailman School of Public Health, and from the Centers for Disease Control and Prevention.

"These findings indicate that prenatal exposure to the insecticide chlorpyrifos not only increases the likelihood of developmental delay, but may have long-term consequences for social adjustment and academic achievement" said lead author and investigator on the study, Virginia Rauh, ScD. "Relatively speaking, the insecticide effects reported here are comparable to what has been seen with exposures to other neurotoxicants such as lead and tobacco smoke."

The study is part of a broader multi-year research project started in 1998, which examines the health effects of exposure of pregnant women and babies to indoor and outdoor air pollutants, pesticides, and allergens. Prior research findings have shown that prenatal chlorpyrifos exposure can reduce birth weight and length. The research has also shown that the residential ban on chlorpyrifos use by the U.S. Environmental Protection Agency has been effective at reducing blood levels of the insecticide.

"Our findings have important public health significance," said Robin Whyatt, DrPH, senior author on the study. "Prior to the ban, chlorpyrifos was one of the most widely used insecticides for residential pest control across the United States. Despite a recent regulatory ban on residential use of chlorpyrifos in the U.S., agricultural applications continue in the U.S. and abroad."

Frederica Perera, DrPH, director of the Columbia Center for Children's Environmental Health noted that, "By identifying environmental exposures that adversely effect fetal development and also affect children's ability to learn, the research provides new opportunities for prevention. However, protection of children's health and development would be best served by thorough testing of chemicals before they are marketed."

The investigators controlled for other exposures that might have contributed to developmental problems such as socioeconomic factors and exposure to tobacco smoke, lead, and other environmental contaminants.

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The study is available at http://pediatrics.aappublications.org/cgi/content/abstract/peds.2006-0338 Other investigators on the study include Robin Garfinkel, Howard Andrews, Lori Hoepner, Dana Barr, Ralph Whitehead, and Deliang Tang.

About the Columbia Center for Children's Environmental Health

The Columbia Center for Children's Environmental Health part of the Mailman School of Public Health at Columbia University is a leading research organization dedicated to understanding and preventing environmentally related disease in children. Founded in 1998, the Center conducts research in New York City, including a World Trade Center Study, as well as Krakow, Poland, and Chongqing, China. Its mission is to improve the respiratory health and cognitive development of children and to reduce their cancer risk by identifying environmental toxicants and conditions related to poverty that increase their risk of disease. In NYC, the Center collaborates with residents and partner organizations in Washington Heights, Harlem and the South Bronx to share research findings with the local communities in ways that are meaningful and usable in daily life. The Center is funded by NIEHS, EPA and private foundations (www.ccceh.org)

About the Mailman School of Public Health

The only accredited school of public health in New York City, and among the first in the nation, Columbia University's Mailman School of Public Health provides instruction and research opportunities to more than 950 graduate students in pursuit of masters and doctoral degrees. Its students and more than 300 multi-disciplinary faculty engage in research and service in the city, nation, and around the world, concentrating on biostatistics, environmental health sciences, epidemiology, health policy and management, population and family health, and sociomedical sciences. (www.mailman.hs.columbia.edu)


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