Preliminary study finds holographic imaging system promising for cancer treatment planning



James Chu, PhD, professor and director of medical physics for the department of radiation oncology at Rush University Medical Center, is studying the potential of the "PerspectaRAD" Spatial 3D system...
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The device looks like something out of an old science fiction movie, but researchers at Rush University Medical Center in Chicago say it holds promise in the treatment of cancer.

The PerspectaŽ Spatial 3D system, developed by Actuality Systems, Inc., creates holographic images inside a 24-inch dome. The full-color, full-motion system can display images of the body revealing the exact location of tumors in true 3D space.

A study led by Rush, which also included Tufts-New England Medical Center, and Rhode Island Hospital/Brown Medical School, found the Perspecta has significant potential to achieve better quality in radiation treatment planning. The study results are being presented this week at the annual meeting of the American Society for Therapeutic Radiology and Oncology in Philadelphia (November 5-9, 2006).

The effectiveness of radiation therapy depends on the medical team's ability to concentrate high radiation doses to the tumors while minimizing the doses to surrounding critical organs. Many of the planning tasks, such as beam placement, volume delineation, and plan evaluation are three dimensional (3D) in nature. However, current planning displays, showing 2D cross-sections or 3D renderings on a flat computer screen, are two dimensional (2D) in nature.

Actuality Systems "PerspectaRAD" Spatial 3D system generates true 3D imagery with a full 360-degree field of view. Using high-speed electronics, a CT scan is projected onto a screen spinning inside a 24-inch transparent dome. The screen, spinning at over 900 rotations per minute, forms a detailed, holographic image that can be viewed and manipulated from any vantage point around the 360-degree dome, by any number of users.

The study compared radiation treatment plans produced on a flat computer screen with those prepared using the Perspecta. Fourteen previously treated plans were replanned using Perspecta. The plans were then reviewed by four physicians who were unaware of what planning device was used.

All the reviewers felt that the Perspecta device allowed better appreciation of 3D relationships of anatomical and dose data than images from a flat screen display. According to the study, the location and size of over or under-dosed regions were also easier to identify on Perspecta. The reviewers reported that Perspecta produced a better plan in six out of 12 brain cases and was better in the one lung cancer case and one breast cancer case studied.

"Our study found the Perspecta Spatial 3D Display provides users complex information in a more efficient and natural way," said James Chu, PhD, professor and director of medical physics for the department of radiation oncology at Rush. "The preliminary data demonstrates that Perspecta has a significant advantage over current 2D radiation planning systems. We are looking forward to an expanded study with a larger number of patients to determine the true potential of this system."

The Perspecta Spatial 3D System has not received FDA approval and is not intended for use in clinical diagnosis, nor may it be used to prevent, diagnose, or treat disease. In the medical field, Perspecta is offered to qualified research institutions only.

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About Actuality Systems
Actuality Systems, Inc. develops computer assisted surgical planning and guidance products that reduce surgical costs through the integration of proprietary 3-D and 4-D visualization, preoperative planning, and intra-operative guidance and decision support. Actuality's initial products in the area of radiation oncology and soft tissue surgical planning reduce hospital and payer costs by increasing surgical accuracy and reducing time in the operating room, reducing patient impact, and reducing repeat procedures or secondary therapy. The company's flagship product, PerspectaRAD, is a spatial 3-D system that displays images that occupy a volume in space, giving users a 360-degree view and simultaneous multi-view collaboration - without goggles.

About Rush University Medical Center
Rush University Medical Center is an academic health center that encompasses a hospital for adults and children with more than 613 staffed beds, the 61-bed Johnston R. Bowman Health Center for older adult and rehabilitative care, and Rush University. Rush is noted for bringing together clinical care and research to address major health problems, including arthritis and orthopedic disorders, cancer, heart disease, mental illness, neurological disorders and diseases associated with aging. In the recent U.S.News & World Report annual Best Hospitals issue, 10 Rush programs are ranked the among the nation's top 50.


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