Different strategies underlie the ecology of microbial invasions

Infectious disease can play a key role in mediating the outcome of competition between rival groups, as seen in the effects of disease-bearing conquistadors in the New World--or, on a much smaller ecological scale, the ability of bacteria to spread their viruses to competing bacteria. In a new study, researchers have compared two different general ways in which bacteria compete with one another, and they have found that each strategy seems to be particularly effective under different ecological circumstances--for example, depending on whether the bacteria are rare invaders or abundant residents. The findings, reported by a group of researchers including Sam P. Brown of the University of Texas at Austin, Cambridge University, and University of Montpellier II, and François Taddei of University of Paris, appear in the October 24th issue of Current Biology.

Bacteria are not always so fortunate as to grow alone in their environment, and they often face competition from other lineages. One widespread solution is to kill these competitors.

In the new work, the researchers explored the relative value to both invading and defensive bacteria of two distinct microbial mechanisms of killing competitors: through the release of chemicals (for example, antibiotics or bacteriocins) and through the release of parasites (for example, bacterial viruses, known as phages). Focusing on the second mechanism in an experimental setting, the researchers showed that even though some of the invading bacteria can be killed by their own phage parasites, upon their death they release a burst of infectious parasites that can kill competitor bacteria. Unlike chemical killing, released parasites trigger an epidemic among susceptible competitors, which become factories producing more parasites. Amplification therefore makes phage carriers able to successfully compete with phage-susceptible bacteria even faster when the carriers are rare, whereas chemical killers can only win in a well-mixed environment when chemical carriers are sufficiently abundant. The findings show that the release of chemical toxins is superior as a resident strategy to repel invasions, whereas the release of parasites is superior as a strategy of invasion.

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The researchers include Sam P. Brown of the University of Texas at Austin in Austin, TX, Cambridge University in Cambridge, UK, and University of Montpellier II in Montpellier, France; Ludovic Le Chat of London School of Hygiene and Tropical Medicine in London, UK; Marianne De Paepe and François Taddei of University Paris 5 and Institut National de la Santé et de la Recherche Médicale in Paris, France.

S.P.B. thanks the European Union, Wellcome Trust, and Human Frontier Science Program (HFSP) for financial support. L.L.C., M.D.P., and F.T. thank the Actions Concertées Incitatives (ACI) and PhD program from the French Ministry of Research, the Institut National de la Santé et de la Recherche Médicale (INSERM), and the Bettencourt Schueller Foundation for financial support.

Brown et al.: "Ecology of Microbial Invasions: Amplification Allows Virus Carriers to Invade More Rapidly When Rare." Publishing in Current Biology 16, 2048–2052, October 24, 2006 DOI 10.1016/j.cub.2006.08.089 www.current-biology.com


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