Cold Spring Harbor Protocols features methods for analyzing protein interactions

Techniques to help biomedical scientists track down the basis of human diseases

Cold Spring Harbor, N.Y., Fri., Sept. 8, 2006 Cold Spring Harbor Protocols, an online journal that publishes methods used in a wide range of biology laboratories, has added over 40 new peer-reviewed protocols to its archive today. The new collection highlights two techniques for characterizing protein interactions, which will aid many cell and molecular biologists--including those who seek to identify the molecular basis of human diseases. Both of these methods are freely accessible from the journal's website: www.cshprotocols.org.

Given the importance of characterizing the molecular networks and signaling pathways that form the biological basis of all living organisms, techniques aimed at probing protein interactions have come to the forefront in recent years. The new methods published today by CSH Protocols will be useful for researchers seeking to identify the molecular partners--such as other proteins or DNA--to which specific proteins bind.

The featured protocols describe how proteins of interest can be labeled with detectable markers and then used to probe thousands of different DNA and protein sequences. The protein-DNA and protein-protein interactions that are identified will eventually be useful for tracking down the causes of diseases, as well as for designing new drugs to aid in their prevention and treatment.

The latest issue of CSH Protocols also includes a variety of other standard and specialized techniques that will be useful to many researchers. These include methods for synchronizing cell growth, investigating embryonic development, and preparing specimens for immunostaining.

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ABOUT COLD SPRING HARBOR PROTOCOLS: CSH Protocols (www.cshprotocols.org) is an online, peer-reviewed journal of techniques used in a wide range of biology laboratories. It is structured as an interactive database, with each protocol cross-linked to related methods, descriptive information panels, and illustrative material to maximize the total information available to investigators. Each protocol is clearly presented and designed for easy use at the bench--complete with reagents, equipment, and recipe lists. Life science researchers can access the entire collection via institutional site licenses, and can add their suggestions and comments to further refine the techniques.

ABOUT COLD SPRING HARBOR LABORATORY PRESS: Cold Spring Harbor Laboratory Press is an internationally renowned publisher of books, journals, and electronic media, located on Long Island, New York. It is a division of Cold Spring Harbor Laboratory, an innovator in life science research and the education of scientists, students, and the public. For more information, visit www.cshlpress.com.


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