Ultra low-dose estrogen shown safe for post-menopausal women

Estradiol delivered via skin patch over two years has no harmful effect on cognitive abilities or health-related quality of life

A study led by researchers at the San Francisco VA Medical Center has shown that extremely low doses of estrogen had no ill effects on the cognitive abilities or general health of older women over the course of two years.

"This is exciting. It shows that women can take estrogen safely," observes lead author Kristine Yaffe, MD, chief of geriatric psychiatry at SFVAMC and associate professor of psychiatry, neurology, and epidemiology at the University of California, San Francisco.

In 2004, study results from the Women's Health Initiative (WHI), a nationwide longitudinal study sponsored by the National Institutes of Health, indicated that estrogen was associated with an increased risk of dementia among women 65 and older, as well as with an increased risk of heart attack and stroke.

"Those results raised a lot of doubts about whether women should be taking estrogen at all," Yaffe notes.

The current study, published in the July 2006 issue of Archives of Neurology, looked specifically at the potential effects of estrogen on cognitive abilities and quality of life. A group of 417 post-menopausal women aged 60 to 80 were randomly assigned to receive a daily .014 milligram dose of either estradiol, a form of estrogen, or a placebo through a skin patch for two years. The women were given a battery of standardized cognitive tests and a test of health-related quality of life at the beginning of the study, after one year, and after two years.

At the end of the study, there was no difference between the two groups in either cognitive abilities or health-related quality of life.

"The results are very reassuring, because it suggests that women can use this patch without harm for two years," says Yaffe. "It would benefit their bones and might have a beneficial effect in terms of hot flashes."

A related study of the same group of women showed a significant increase in bone density, without adverse health effects, in the women who took estradiol compared to the women who took placebo. The current study was a pre-planned secondary investigation.

Yaffe speculates that the differences in health and cognition outcomes between these two studies and the WHI studies could be related to three factors: dose, type of estrogen, and means of delivery.

The women in the WHI studies received .625 milligrams per day of conjugated estrogen a mixture of estrogen from several different sources in pill form. In contrast, the women studied by Yaffe and her associates received a daily dose of estradiol pure human estrogen that was over 44 times smaller and delivered through a skin patch.

"The different between a patch and a pill is significant because medications taken in pill form are processed through the liver before they reach the bloodstream," explains Yaffe. "It's thought that estrogen in pill form might stimulate the liver to produce substances that can lead to clotting or other adverse side effects. With a patch, you bypass the liver and go straight to the blood."

Yaffe notes that since the WHI results were announced in 2004, "the field of estrogen research has been stymied. Hopefully, this study will start to turn the tide."

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Coauthors of the study are Eric Vittinghoff, PhD, of UCSF; Kristine E. Ensrud, MD, MPH, of the University of Minnesota and the Minneapolis VA Medical Center; Karen C. Johnson, MD, MPH, of the University of Tennessee Health Sciences Center; Susan Diem, MD, MPH, of UM; Vladmir Hanes, MD, of Berlex, Inc.; and Deborah Grady, MD, MPH, of SFVAMC and UCSF.

The research was funded by Berlex, Inc., with partial support from the National Institute of Aging.

SFVAMC has the largest medical research program in the national VA system, with more than 200 research scientists, all of whom are faculty members at UCSF.

UCSF is a leading university that consistently defines health care worldwide by conducting advanced biomedical research, educating graduate students in the life sciences, and providing complex patient care.


Last reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
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