In an attempt to develop a classification of human lung tumors that might help to predict outcome, Hongye Liu and colleagues from the Children's Hospital Boston compared gene expression patterns in patients with lung cancer with those seen during mouse lungs during development. They show that the human tumors that had a gene expression pattern most similar to that seen in early mouse lung development had a poorer outcome.
PLEASE MENTION THE OPEN-ACCESS JOURNAL PLoS MEDICINE (www.plosmedicine.org) AS THE SOURCE FOR THESE ARTICLES AND PROVIDE A LINK TO THE FREELY-AVAILABLE TEXT. THANK YOU.
All works published in PLoS Medicine are open access. Everything is immediately available without cost to anyone, anywhere--to read, download, redistribute, include in databases, and otherwise use--subject only to the condition that the original authorship is properly attributed. Copyright is retained by the authors. The Public Library of Science uses the Creative Commons Attribution License.
Citation: Liu H, Kho AT, Kohane IS, Sun Y (2006) Predicting survival within the lung cancer histopathological hierarchy using a multi-scale genomic model of development. PLoS Med 3(7): e232.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE
VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030232
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-03-07-liu.pdf
Children's Hospital Boston
320 Longwood Ave.
Boston, MA 02115 United States of America
About PLoS Medicine
PLoS Medicine is an open access, freely available international medical journal. It publishes original research that enhances our understanding of human health and disease, together with commentary and analysis of important global health issues. For more information, visit http://www.plosmedicine.org
Last reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
Published on PsychCentral.com. All rights reserved.