A mechanism observed in other species as well
However, Michel Georges' team investigated further. Pursuing the study using bioinformatic approaches, the team identified polymorphisms (common mutations) among humans and mice that are likely to act in the same way as they do in the Texel breed. It appears, therefore, that this new kind of mutation, discovered while studying sheep, could contribute significantly to the phenotypic variation observed in many species among which humans including the hereditary predisposition to various diseases.
Researchers at ULg have thus produced a database available online that compiles all these mutations (the Patrocles database: http://www.patrocles.org). It will assist researchers around the world in discovering similar phenomena for other phenotypes including hereditary diseases.
Prof. Michel GEORGES, Animal Genomics Department, Faculty of Veterinary Medicine and CBIG (Center for Biomedical Integrative Genoproteomics), University of Liège, Tel +32 4 366 41 51 - Mail firstname.lastname@example.org
CLOP, A.; MARCQ, F.; TAKEDA, H.; PIROTTIN, D.; TORDOIR, X.; BIBÉ, B.; BOUIX, J.; CAIMENT, F.; ELSEN, J.M.; EYCHENNE, F.; LARZUL, C.; LAVILLE, E.; MEISH, F. ; MILENKOVIC, D. ; TOBIN, J.; CHARLIER, C.; GEORGES, M. (2006). « A mutation revealing a potential illegitimate miRNA target site in the myostatin gene is a Quantitative Trait Nucleotide with major effect on muscularity in sheep". Nature Genetics, Advance online publication, 2006/06/04 - www.nature.com/ng/index.html
With the support of Walloon Ministery for Agriculture, French Community of Belgium (ARC), Federal Scientific Policy (PAI) and EU-Strep program Callimir
Last reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
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