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Gene expression in labor
A Research Article, Perspective and e-Letter all published today discuss the use of microarrays to discover genes involved in childbirth. The three papers highlight the complexity of such gene expression analyses but also how crucial it is to make original data available for reanalysis.
In the Research Article (Labor-Associated Gene Expression in the Human Uterine Fundus, Lower Segment, and Cervix), Radek Bukowski and colleagues from the University of Texas, Galveston used microarrays to assess labor-associated gene expression profiles in the top, lower part and cervix of the uterus and describe networks of co-regulated and co-expressed genes. In an accompanying Perspective (Insights into the Physiology of Childbirth Using Transcriptomics), Roberto Romero from the National Institute of Child Health and Human Development -- one of the peer reviewers of the paper -- and colleagues discuss the study further and reanalyze the data of Bukowski and colleagues, using different statistical methods and coming to some different conclusions about the changes in gene expression. Finally, in an e-Letter Bukowski and colleagues respond to Romero and colleagues, acknowledging that "Such discussion is mandatory if results of scientific techniques such as gene array are to be correctly interpreted and used as the basis for future improvements in patient care"
Citation: Bukowski R, Hankins GDV, Saade GR, Anderson GD, Thornton S (2006) Labor-associated gene expression in the human uterine fundus, lower segment, and cervix. PLoS Med 3(6): e169.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030169
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-03-06-bukowski.pdf
University of Texas Medical Branch
Obstetrics and Gynecology
301 University Blvd
Galveston, TX 77555 United States of America
Related PLoS Medicine Perspectives article:
Citation: Romero R, Tarca AL, Tromp G (2006) Insights into the physiology of childbirth using transcriptomics. PLoS Med 3(6): e276.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030276
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-03-06-romero.pdf
Perinatology Research Branch, Intramural Division
Bethesda, Maryland, United States of America
The e-Letter by Radek Bukowski and colleagues in response to Robert Romero will be published on the 13th June and will be linked to the Romero perspective. Please also visit the e-Letters section of www.plosmedicine.org
Anti-Interferon Autoantibodies in Autoimmune Polyendocrinopathy Syndrome Type 1
Almost all of nearly 100 APS1 patients studied made large amounts of auto-antibodies that blocked the function of IFN-a and IFN-w. The antibodies appeared early during development of the disease and may play a role in its etiology.
Citation: Meager A, Visvalingam K, Peterson P, Möll K, Murumägi A, et al. (2006) Anti-interferon autoantibodies in autoimmune polyendocrinopathy syndrome type 1. PLoS Med 3(7): e289.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030289
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-03-07-meager.pdf
Nat. Inst. for Biol. Standards and Control
Immunology & Endocrinology
Potters Bar, Hertfordshire EN6 3QG United Kingdom
Related PLoS Medicine Perspectives article:
Citation: Levin M (2006) Anti-interferon auto-antibodies in Autoimmune Polyendocrinopathy Syndrome Type 1. PLoS Med 3(7): e292.
PLEASE ADD THE LINK TO THE PUBLISHED ARTICLE IN ONLINE VERSIONS OF YOUR REPORT: http://dx.doi.org/10.1371/journal.pmed.0030292
PRESS-ONLY PREVIEW OF THE ARTICLE: http://www.plos.org/press/plme-03-07-levin.pdf
Brighton and Sussex Medical School
Brighton, United Kingdom
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