Investigators led by Katherine Janeway, MD, and George Demetri, MD, of the Ludwig Center for Cancer Research at Dana-Farber will discuss results of a preliminary clinical trial in which three children -- two teenagers and a pre-teen -- with metastatic Gastrointenstinal Stromal Tumor (GIST) resistant to imatinib (Gleevecā) were treated with sunitinib (Sutentā).
Sutent was recently approved by the FDA for use in GIST patients as a multi-targeted "smart drug" that inhibits several growth-stimulating kinase enzymes in cancer cells. With sunitinib therapy, the GIST lesions stabilized or decreased in size in all three pediatric patients, with one patient experiencing a complete remission of two cancerous lung nodules. Positron emission tomography (PET) scanning, a sophisticated imaging technique, in two patients showed significant decreases in tumor-related activity at all sites where the disease was present. Side effects of sunitinib were manageable in all three patients.
GIST most often occurs in people over the age of 40 and can arise anywhere in the gastrointestinal tract. Studies have estimated that there are at least 5,000 new cases a year in the United States. Very rare in children, GIST was found to account for less than 5 percent of all cases of the disease at one major cancer center.
In most young people with GIST, the cancer cells do not have detectable mutations in the genes encoding the KIT and PDGFR-a, kinases, although these signaling proteins are uncontrollably activated. Adults with GIST whose tumors lack mutations in these genes generally do not benefit from imatinib therapy, but show significant improvement with sunitinib treatment. These findings led researchers to test sunitinib in pediatric GIST patients.
"The results of this initial trial confirm our prior observations that sunitinib is an effective therapy for GIST cells without kinase mutations, and it is particularly important for these pediatric patients with imatinib-resistant GIST," says Demetri, the study's senior author and an associate professor of medicine at Harvard Medical School. "Follow-up with expanded studies of sunitinib in children with GIST and other pediatric cancers is definitely warranted."
Funding for the study was provided in part by the Ludwig Center at Dana-Farber Cancer Institute and Pfizer, Inc.
Dana-Farber Cancer Institute (www.danafarber.org) is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center (DF/HCC), designated a comprehensive cancer center by the National Cancer Institute. The Ludwig Center for Cancer Research at Dana-Farber is a new academic unit dedicated to the discovery and development of molecularly-targeted diagnostic and therapeutic tools for cancer.
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