Levesque, in collaboration with Dr. James Brophy , a cardiologist/epidemiologist and Director of the Technology Assessment Unit (TAU) at the MUHC and Associate Professor of Medicine at McGill University, and Bin Zhang, also a doctoral student in the Department of Epidemiology and Biostatistics, discovered that the risk of heart attack from Vioxx is much more acute than previously recognized. "A quarter of individuals in our study who suffered an acute myocardial infarction did so within two weeks of their first Vioxx prescription," says Levesque.
"The additional cardiovascular risk from Vioxx actually decreased with longer duration of use, suggesting that the period of highest susceptibility for most people taking Vioxx may occur earlier than previously believed," noted Levesque. The study also documents that cardiovascular risk returns to normal within one month of stopping the drug.
Vioxx was voluntarily withdrawn from the market on September 30, 2004 after a study showed it doubled patients' risk of heart attacks and strokes after 18 months of use. This MUHC study is the first to specifically address the question of the timing of cardiovascular risk associated with COX-2 inhibitors.
"This study adds important new information on how the COX-2 inhibitors like Vioxx affect the heart," said Dr. Peter Liu, Scientific Director of the CIHR Institute of Circulatory and Respiratory Health. "Physicians must carefully assess the risk versus benefit, and help the patient to watch for any new symptoms during the start of these medications. We are delighted that this research from the McGill University Health Centre can help us further to better the health of Canadians."
This study was funded by the Canadian Institutes for Health Research (CIHR).
The Research Institute of the McGill University Health Centre (RI MUHC) is a world-renowned biomedical and health-care hospital research centre. Located in Montreal, Quebec, the institute is the research arm of the MUHC, a university health center affiliated with the Faculty of Medicine at McGill University. The institute supports over 500 researchers, nearly 1000 graduate and post-doctoral students and operates more than 300 laboratories devoted to a broad spectrum of fundamental and clinical research. The Research Institute operates at the forefront of knowledge, innovation and technology and is inextricably linked to the clinical programs of the MUHC, ensuring that patients benefit directly from the latest research-based knowledge. For further details visit: www.muhc.ca/research.
The McGill University Health Centre (MUHC) is a comprehensive academic health institution with an international reputation for excellence in clinical programs, research and teaching. The MUHC is a merger of five teaching hospitals affiliated with the Faculty of Medicine at McGill University––the Montreal Children's, Montreal General, Royal Victoria, and Montreal Neurological Hospitals, as well as the Montreal Chest Institute. Building on the tradition of medical leadership of the founding hospitals, the goal of the MUHC is to provide patient care based on the most advanced knowledge in the health care field, and to contribute to the development of new knowledge.
Last reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
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