As will be published in the June edition of the scientific journal Nature Medicine, Lazarus' research team has made great strides in determining how IVIg works, a major milestone in the study of this product. They have also found evidence that a synthetic replacement for IVIg could be developed that would not only be cheaper and easier to produce in mass quantities, but could also lead to more effective treatments for patients. Lazarus says, "this work unravels some of the mystery surrounding how IVIg functions in patients with ITP, and will allow us to develop new and more powerful therapeutics in the future. In addition, this discovery should allow for a more consistent product with less side-effects than the IVIg currently in use."
Patients like Liliane Keryluk in Ottawa have relied on IVIg for treatment. She has suffered from ITP, and is very hopeful that new, more effective and safer treatments may be developed as a result of Dr. Lazarus' research. "While I understand that this research is still in early stages, I am very excited that an important step forward has been made in the treatment of my disease, and for the thousands of others who also suffer from ITP," says Liliane.
Lazarus' team's research is made possible in part thanks to funding received from the Canadian Institute for Health Research. The next step in his research studies will be to move on to clinical trials as he continues making strides in understanding how IVIg works. He is a scientist with Canadian Blood Services and an adjunct scientist with St. Michael's Hospital, as well as an associate professor of medicine at the University of Toronto.
Attn Editors: High resolution stock photos are available of Dr. Lazarus in the laboratory.
Dr. Lazarus' article in Nature Medicine can be viewed online at http://dx.doi.org/ using the DOI (10.1038/Nm1416)
About Canadian Blood Services
Canadian Blood Services is a national, not-for-profit charitable organization that manages the blood supply in all provinces and territories outside of Quebec and oversees the country's Unrelated Bone Marrow Donor Registry. A dedicated team of about 4,500 staff and 17,000 volunteers enable us to operate 41 permanent collection sites and more than 19,000 donor clinics annually. Canadian Blood Services is a non-governmental organization, however the Provincial and Territorial Ministers of Health provide operational funding, and the federal government, through Health Canada, is responsible for regulating the blood system. For more information, please visit www.blood.ca
About St. Michael's Hospital
St. Michael's Hospital is a Catholic teaching and research hospital, fully affiliated with the University of Toronto, specializing in heart and vascular disease, inner city health, trauma/neurosurgery, diabetes comprehensive care, minimal access therapeutics, and neurological and mobility disorders. In addition to being a world-renowned research and academic center, St. Michael's Hospital remains one of the world's best-known symbols for leading, innovative and compassionate patient care. By launching the Li Ka Shing Knowledge Institute, the Keenan Research Centre and the Li Ka Shing International Centre in Health Care Education, St. Michael's Hospital is raising the bar as a prominent influencer in the provision of excellent patient care, research and education. For more information, please visit www.stmichaelshospital.com
Communications Specialist, R&D
Canadian Blood Services
Tel: (613) 739-2442
Cel: (613) 558-1990
St. Michael's Hospital
Tel: (416) 864-6094
Last reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
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