News tips from the Journal of Neuroscience

07/20/05

Mice That Feel No Pain

Ken-ichiro Kuwako, Akari Hosokawa, Isao Nishimura, Taichi Uetsuki, Masashi Yamada, Shigeyuki Nada, Masato Okada, and Kazuaki Yoshikawa

Kuwako et al. evaluate mice lacking a paternal copy of the necdin gene (Ndn+m/-p), a maternally imprinted, patternally expressed multifunctional signaling protein. The mice share behavioral and developmental features with Prader-Willi syndrome (PWS), a genomic imprinting-associated developmental disorder. Ndn+m/-p mice displayed a higher tolerance for heat-induced pain, as is also frequent in PWS. The authors speculate that necdin may play an analogous role in brain-derived neurotrophic factor/TrkB signaling in central neurons.

Source: Eurekalert & others

Last reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
    Published on PsychCentral.com. All rights reserved.

 

 

Don't be too timid and squeamish about your actions. All life is an experiment. The more experiments you make the better.
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