Why IL-2 works in HIV


HIV infection decreases the number of CD4+ T lymphocytes and this increases the risk of infection. Administration of IL-2 to HIV-infected people can boost CD4 cell number, but the mechanisms underlying this were not clear.

In a study appearing online on July 14 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Joseph Kovacs and colleagues from the NIH use cutting-edge in vivo labeling techniques to show that intermittent administration of IL-2 to HIV-infected patients induces a high level of proliferation of both CD4 and CD8 cells, followed by a remarkably prolonged survival of only the CD4 cells.

These results help explain the preferential CD4 cell increases seen in patients receiving intermittent IL-2 therapy and provide new insight into the biological activities of exogenously administered IL-2.

Source: Eurekalert & others

Last reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
    Published on PsychCentral.com. All rights reserved.



Times of general calamity and confusion have ever been productive of the greatest minds. The purest ore is produced from the hottest furnace.
~ Charles Caleb Colton