Stroke is a major medical problem, with only very limited treatment options. In a study appearing online on July 7 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Armin Schneider and colleagues from Axaron Biosciences describe new roles for granulocyte colony-stimulating factor (G-CSF) in treating stroke and other central nervous system roles of this protein.
The team reports that G-CSF has potent cell protective effects on mature neurons, explaining why it has been shown to be useful in animal stroke models. Moreover, G-CSF drives neuronal differentiation of adult neural stem cells in the brain, and has profound impact on long-term functional outcome after cerebral ischemia. The authors show that G-CSF itself is a neuronally expressed protein in the brain, and that systemic G-CSF can penetrate the intact blood-brain-barrier.
Thus, G-CSF is a potentially novel treatment for stroke and neurodegeneration. G-CSF doubles hippocampal neurogenesis even in normal, non-ischemic animals, making it a potential drug candidate for diseases where disturbances in neurogenesis are a factor.
Source: Eurekalert & othersLast reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
Published on PsychCentral.com. All rights reserved.
The greater the difficulty, the more glory in surmounting it. Skillful pilots gain their reputation from storms and tempests.