Vanderbilt-Ingram scientists release findings at DoD 'Era of Hope' Breast Cancer Meeting


PHILADELPHIA, PENN. (June 10, 2005) -- More than 15 Vanderbilt-Ingram Cancer Center researchers are presenting their study findings at the U.S. Department of Defense (DoD) Breast Cancer Research Program's "Era of Hope" meeting in Philadelphia, Penn.

The conference June 9-11 brings together scientists, physicians, military representatives and breast cancer survivors to present and discuss the latest scientific research funded by the DoD. To date, Vanderbilt-Ingram researchers have received 49 grants resulting in more than $11 million in funding from the program.

"DoD grants are particularly valuable because they focus on innovation, as well as more conventional research avenues," said Lynn Matrisian, Ph.D., Ingram Professor of Cancer Research and Chair of the Department of Cancer Biology, who will be presenting on "The Tumor Microenvironment" during the meeting. "This conference is an exciting event, because it brings together such a variety of researchers, and it allows us to showcase our work to a very important audience the advocates, those whose lives have been touched by breast cancer."

Matrisian is one of five Vanderbilt-Ingram researchers serving as a featured speaker or symposium presenter at the gathering. Darryl Bornhop, Ph.D., professor of Chemistry, will speak on "Diagnostic Molecular Imaging: MR and Nuclear Applications for Improving Breast Cancer Detection and Diagnosis," and Todd Giorgio, Ph.D., associate professor of Biomedical Engineering and Chemical Engineering, will present "Biological Pathway Discovery and Targeted Interference." Bo Lu, Ph.D., assistant professor of Radiation Oncology, will discuss "Arresting Cancer Proliferation through Early Detection and Angiogenic Therapies," and Jin Chen, associate professor of Cancer Biology, will speak on "Identifying and Targeting Biological Mechanisms of Angiogenesis."

Numerous Vanderbilt-Ingramresearchers will present their research findings through posters and abstract presentations. Topics include:

  • Association of Ginseng Use with Survival and Quality of Life among Breast Cancer Patients
  • Soy Food Intake, Estrogen Receptor Polymorphisms, and Breast Cancer Survival
  • A Critical Role of EphA2 Tyrosine Kinase in Breast Tumor Angiogenesis and Metastasis
  • The Role of NF-KappaB Signaling in Macrophages on Mammary Development and Neoplasia
  • Simultaneous Profiling of Protein and RNA Expression by Mass Spectrometry in Intact Breast Tissue Samples
  • Control of C-MYC Function by the Tumor Suppressor P19ARF
  • Genetic Polymorphisms in the Mangnese Superoxide Dismutase and Glutathione Peroxidase 1 Genes, Antioxidant Intake, and Breast Cancer Risk: A Population-Based Case-Control Study
  • Regulation of Gene Expression by P63 in Breast Myoepithelial Cells
  • In Vitro Analysis of Magnetic Field Induced Superparamagnetic Nanoparticle Dynamics in the Extracellular Matrix
  • Identification of Novel P53 Target Genes in Mammary Epithelial Cells
  • The Role of EPHA2 Receptor Tyrosine Kinase in Host-Tumor Interactions
  • Ectodomain Cleavage of ERBB-4, A Receptor Tyrosine-Kinase

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