Study shows M2A capsule endoscopy improves clinical outcomes in IBD patients

05/17/04

'Pill camera' is a highly effective diagnostic and therapeutic tool for IBD

(New Orleans - May 18, 2004) A researcher at Mount Sinai School of Medicine today reported study data indicating that M2A capsule endoscopy --examination of the intestinal tract with the so-called "pill camera"-- can play a significant role in the clinical diagnosis and therapeutic decision making in patients with Inflammatory Bowel Disease (IBD).

Principal investigator Peter E. Legnani, MD, clinical instructor in the Division of Gastroenterology, Samuel Bronfman Department of Medicine, presented the findings in New Orleans at Digestive Disease Week, the world's largest and most prestigious meeting on gastroenterology.

Researchers found that among patients with confirmed Crohn's disease, clinical decisions based on capsule endoscopy findings improved outcomes in 95% of patients. The investigators also demonstrated that capsule endoscopy was 100 percent effective in excluding a diagnosis of Crohn's disease.

"Capsule endoscopy is a highly effective tool in the diagnosis and therapeutic decision making of patients with IBD-related illnesses," said Dr. Legnani. "The results derived from capsule endoscopy procedures positively affect patient management, helping physicians guide their treatment decisions with the ultimate goal of improving outcomes in this patient population."

The study reviewed the diagnostic findings from the capsule endoscopies of 65 patients with Inflammatory Bowel Disease (IBD)-related indications and examined the effect of those findings on diagnostic and therapeutic outcomes. Patients admitted to the study had evidence of IBD diagnosed through prior endoscopic procedures. The patients were segmented into suspected or confirmed Crohn's disease and further categorized by the results of previous tests. In patients with an abnormal small bowel series or abdominal pain, 30 of 32 were found not to have Crohn's. Based on a 19 month follow-up confirming the absence of Crohn's disease, capsule endoscopy demonstrated a negative predictive value of 100 percent. For those patients with known IBD and inconclusive small bowel radiography, capsule endoscopy yielded findings in 18 of 33 patients (57%). Overall, among the 20 out of 21 patients in whom capsule endoscopy yielded diagnostic findings, 20 (95%) showed clinical improvement due to therapeutic decisions guided by the diagnostic findings.

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