Cincinnati children's study could lead to new therapeutics
CINCINNATI -- Scientists at Cincinnati Children's Hospital Medical Center have identified a missing piece of the puzzle of how lung damage occurs in cystic fibrosis (CF).
CF is a life-threatening, genetic disease that causes chronic lung infections and impairs digestion. The discovery, published in the current issue of Nature Immunology, provides impetus for the development of novel therapeutics that decrease inflammation in children with CF.
The Cincinnati Children's team found a deficiency in the airways of children with CF of a class of molecules called lipoxins, which are key regulators of inflammation. "When we give analogs of this molecule (lipoxin-like molecules) in mouse models of CF, the molecules do what we'd like them to do -- suppress acute inflammation, switch on the chronic inflammatory process and ameliorate disease -- suggesting that this class of molecules might have therapeutic potential in CF," says Christopher Karp, MD, director of Molecular Immunology at Cincinnati Children's and the study's main author.
Over time, the persistent combination of infection and inflammation in CF lungs leads to their destruction. Several studies in recent years suggest that the frequent and prolonged airway inflammation in CF lungs leads to the eventual cardio-respiratory failure that is the primary cause of death in people with CF.
"It's traditionally been thought that the basic problem in the CF lung is an inability to clear bacteria, with infection leading secondarily to lung-damaging inflammation," says Dr. Karp. "Recent studies suggest it may well be the other way around: abnormally vigorous and prolonged airway inflammatory may be a primary problem. Such responses are inefficient at clearing bacteria, may damage the airway in ways that promote colonization with bacteria, and over time lead to airway destruction.
"It's clear that the inflammatory response of the airway in CF patients is abnormal from the earliest time you look at it. People haven't traditionally thought of CF as an immunologic disease, but it is."
Inflammation in the CF airway is acute inflammation -- inflammation dominated by neutrophils, which are white blood cells that serve as a frontline protector against infectious pathogens. Normally, neutrophilic inflammation occurs for a short period of time. If the infection isn't cleared, the inflammation shifts from being acute to chronic and involves different kinds of white blood cells, such as lymphocytes and macrophages.
The shift to chronic inflammation generally is a good thing, because chronic inflammation is less damaging to tissue. In patients with CF, however, the acute inflammatory response never changes to a chronic response. Lipoxins have been shown to play an important immunoregulatory role, acting as a key part of the switch that shifts the inflammatory response from acute to chronic.
"The more we know about the unique cycle of inflammation in CF, the better we are able to develop the appropriate tools to fight it. This study adds to our knowledge about CF and suggests an additional therapeutic direction," said Robert J. Beall, Ph.D., president and CEO of the Cystic Fibrosis Foundation. "If we can reduce the rate at which lung tissue is damaged, we should be able to increase life expectancy and delay, or even eliminate the need for difficult and costly lung transplantation procedures."
CF is a genetic disease affecting approximately 30,000 children and adults in the United States. A defective gene causes the body to produce an abnormally thick, sticky mucus that clogs the lungs and leads to life-threatening lung infections. These thick secretions also obstruct the pancreas, preventing digestive enzymes from reaching the intestines to help break down and absorb food.
People with CF have a variety of symptoms including: very salty-tasting skin; persistent coughing, at times with phlegm; wheezing or shortness of breath; an excessive appetite but poor weight gain; and greasy, bulky stools. Symptoms vary from person to person due, in part, to the more than 1,000 mutations of the CF gene. The median age of survival for a person with CF is in the early 30s.
Co-author of the study was Nicos Petasis, PhD, of the University of Southern California.
Source: Eurekalert & othersLast reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
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