Sophisticated silencing strategies
Since small RNA molecules were discovered just over ten years ago, it has become clear that these once overlooked bits of genetic material play a decidedly large role in controlling gene expression and thus regulating a diverse array of cellular processes. They typically accomplish these tasks by targeting specific nucleotide sequences to shut down gene expression, and scientists are now starting to apply related strategies to inactivate specific genes for research and therapeutic purposes (see related feature article by Richard Robinson at http://www.plosbiology.org/plosonline/?request=get-document&doi=10.1371/journal.pbio.0020028).
Yet much remains to be learned about the details of small-RNA-mediated silencing, and a study lead by James Carrington (Oregon State University) and Steve Jacobsen (UCLA) now demonstrates that plants have evolved multiple systems to produce distinct classes of small RNAs with specialized functions. These include genome maintenance, the regulation of specific endogenous target genes, and defense against viral and transposon sequences. These results shed light on the evolution of RNA-mediated gene silencing and have implications for the adaptation of such silencing strategies for various purposes.
Source: Eurekalert & othersLast reviewed: By John M. Grohol, Psy.D. on 21 Feb 2009
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