Burning More Calories Linked to Reduction in Alzheimer's Risk

A new study has found that people with Alzheimer’s disease or mild cognitive impairment have larger gray matter volume in key areas of the brain responsible for memory and cognition if their exercise-associated calorie burn was high.

A growing number of studies indicate physical activity can help protect the brain from cognitive decline, said investigator James T. Becker, Ph.D., a professor of psychiatry at the University of Pittsburgh School of Medicine. But typically people are more sedentary as they get older, which also is when the risk for developing Alzheimer’s disease and other dementias increases.

“Our current treatments for dementia are limited in their effectiveness, so developing approaches to prevent or slow these disorders is crucial,” Becker said. “Our study is one of the largest to examine the relationship between physical activity and cognitive decline, and the results strongly support the notion that staying active maintains brain health.”

Led by Cyrus Raji, M.D., Ph.D., formerly a student at Pitt School of Medicine and now a senior radiology resident at University of California, Los Angeles, the researchers examined data obtained over five years from nearly 876 people 65 or older participating in the multicenter Cardiovascular Health Study.

All participants had brain scans and periodic cognitive assessments. They also were surveyed about how frequently they engaged in physical activities, such as walking, tennis, dancing, and golfing, to assess their calorie expenditure or energy output per week.

Using mathematical modeling, the researchers found that the individuals who burned the most calories had larger gray matter volumes in the frontal, temporal, and parietal lobes of the brain, areas that are associated with memory, learning, and performing complex cognitive tasks.

In a subset of more than 300 participants at the Pittsburg site, those with the highest energy expenditure had larger gray matter volumes in key areas on initial brain scans and were half as likely to have developed Alzheimer’s disease five years later, according to the study‚Äôs findings.

“Gray matter houses all of the neurons in your brain, so its volume can reflect neuronal health,” Raji explained. “We also noted that these volumes increased if people became more active over five years leading up to their brain MRI.”

He added that advancements in technology might soon make it feasible to conduct baseline neuroimaging studies of people who already have mild cognitive impairment or who are at risk for a dementia disorder, with the aim of prescribing lifestyle approaches, such as physical activity, to prevent further memory deterioration.

“Rather than wait for memory loss, we might consider putting the patient on an exercise program and then rescan later to see if there are any changes in the brain,” Raji said.

The study was published in the Journal of Alzheimer’s Disease.

Source: University of Pittsburgh School of Medicine