Mid-Life Falls May Be Linked to Later Parkinson's

New research finds that Parkinson’s patients have a higher risk of injuries and hip fractures from falls up to 26 years before being diagnosed with the disease.

Swedish researchers believe the higher proportion of fall-related injuries can partly be explained by reduced balance, which could be a significant early sign of illness.

Study results appear in the journal PLOS Medicine.

Researchers at Umeå University had previously used a cohort study to investigate if male patients with Parkinson’s disease had low muscle strength in the arms already at the time of military enrolment in early adulthood. The study found a reduced muscular strength in the arms on average already 30 years prior to Parkinson’s diagnosis.

Based on these results, researchers wondered if this reduced muscular strength also could be associated with an increased risk of injurious falls and hip fractures.

The new study results show that early changes manifested in a reduced muscular strength also seem to result in an increased risk of injurious falls and fractures several years before diagnosis.

The correlation also shows signs of the gradual dysfunctional balance reactions and impaired mobility being present at a much earlier stage of Parkinson. Scientists have previously thought these changes occurred in relatively late stages of Parkinson’s.

“We asked ourselves if fall-related injuries at an early age could be a warning sign of the deteriorating balance that is characteristic to Parkinson’s disease,” said Helena Nyström, a doctoral student at the Department of Community Medicine and Rehabilitation and co-author of the article.

In the current study, researchers examined health data from all Swedes 50 years or older in 2005. Out of these, 24.412 were diagnosed with Parkinson’s in the period of 1988-2012, and these individuals were matched against 10 people each in the control group. Researchers found that 18 percent of all Parkinson’s patients (before diagnosis) and 11.5 per cent of controls had at least one fall-related injury.

“By investigating health data from registers, we could see a correlation between individuals who were later diagnosed with Parkinson’s and who were more often involved in injurious falls. It was also shown that the higher risk of hip fractures could be measured more than two decades before the diagnosis,” Nyström said.

Falls are a serious health risk and hip fractures are a common contributing factor to early death among the older population. The risk of hip fractures are especially high in people with Parkinson’s, something which is likely caused by reduced balance and lessened ability to rotate the body in the event of a fall in order to protect the hip.

Parkinson’s disease is usually diagnosed around the age of 70. The disease has an insidious onset and at first mostly affects mobility and balance.

Previous research has shown that the disease manifests itself early in various ways. Balance and muscular strength is negatively affected at a later stage.

Source: Umea University/EurekAlert
 
Man with a knee injury photo by shutterstock.