A simple test that measures how fast people walk and whether they have any cognitive complaints can predict the likelihood of developing dementia, according to a new study.
The study, involving about 27,000 older adults on five continents, found that nearly one in 10 met the criteria for pre-dementia based on this simple test. Those who tested positive for pre-dementia were twice as likely to develop dementia within 12 years, according to researchers at the Albert Einstein College of Medicine of Yeshiva University and Montefiore Medical Center in the Bronx.
The test diagnoses motoric cognitive risk syndrome (MCR). Testing for the newly described syndrome involves measuring gait speed — our manner of walking — as well as asking a few simple questions about a patient’s cognitive abilities, both of which take just seconds, the researchers explained.
Because the test doesn’t rely on technology, it can be easily done in a clinical setting, allowing a diagnosis in the early stages of dementia, according to the researchers.
Early diagnosis is critical because it allows time to identify and possibly treat the underlying causes of the disease, which may delay or even prevent the onset of dementia in some cases, researchers noted.
“In many clinical and community settings, people don’t have access to the sophisticated tests — biomarker assays, cognitive tests or neuroimaging studies — used to diagnose people at risk for developing dementia,” said Joe Verghese, M.B.B.S., a professor in the Saul R. Korey Department of Neurology and of medicine at Einstein and chief of geriatrics at Einstein and Montefiore.
“Our assessment method could enable many more people to learn if they’re at risk for dementia, since it avoids the need for complex testing and doesn’t require that the test be administered by a neurologist.
“The potential payoff could be tremendous — not only for individuals and their families, but also in terms of healthcare savings for society. All that’s needed to assess MCR is a stopwatch and a few questions, so primary care physicians could easily incorporate it into examinations of their older patients.”
According to the Centers for Disease Control and Prevention, up to 5.3 million Americans — about one in nine people 65 years and over — have Alzheimer’s disease, the most common type of dementia. That number is expected to more than double by 2050 due to the population aging, researchers said.
“As a young researcher, I examined hundreds of patients and noticed that if an older person was walking slowly, there was a good chance that his cognitive tests were also abnormal,” said Verghese. “This gave me the idea that perhaps we could use this simple clinical sign — how fast someone walks — to predict who would develop dementia.”
“In a 2002 New England Journal of Medicine study, we reported that abnormal gait patterns accurately predict whether people will go on to develop dementia. MCR improves on the slow gait concept by evaluating not only patients’ gait speed, but also whether they have cognitive complaints.”
The new study, published in Neurology, the medical journal of the American Academy of Neurology, reported on the prevalence of MCR among 26,802 adults, 60 and older, without dementia or disability enrolled in 22 studies in 17 countries. About 9.7 percent met the criteria for MCR, including an abnormally slow gait and cognitive complaints.
While the syndrome was equally common in men and women, highly educated people were less likely to test positive for MCR compared with less-educated individuals, the researchers noted.
A slow gait is a walking speed slower than about one meter per second, which is about 2.2 miles per hour. Less than 0.6 meters per second (or 1.3 mph) is “clearly abnormal,” according to Verghese.
To test whether MCR predicts future dementia, the researchers focused on four of the 22 studies. These tested 4,812 people for MCR and then evaluated them annually over an average follow-up period of 12 years to see which ones developed dementia. Those who met the criteria for MCR were nearly twice as likely to develop dementia over the following 12 years compared with people who did not, the researchers discovered.
Verghese emphasizes that a slow gait alone is not sufficient for a diagnosis of MCR.
“Walking slowly could be due to conditions such as arthritis or an inner ear problem that affects balance, which would not increase risk for dementia,” he explained. “To meet the criteria for MCR requires having a slow gait and cognitive problems. An example would be answering ‘yes’ to the question, ‘Do you think you have more memory problems than other people?'”
“For patients meeting MCR criteria, the next step is to look for the causes of their slow gait and cognitive complaints,” Verghese said. “The search may reveal underlying — and controllable — problems,” he noted.
Evidence increasingly suggests that brain health is closely tied to cardiovascular health — meaning that treatable conditions such as hypertension, smoking, high cholesterol, obesity, and diabetes can interfere with blood flow to the brain and thereby increase a person’s risk for developing Alzheimer’s and other dementias,” he said.
But what if an underlying problem can’t be found?
“Even in the absence of a specific cause, we know that most healthy lifestyle factors, such as exercising and eating healthier, have been shown to reduce the rate of cognitive decline,” said Verghese.
“In addition, our group has shown that cognitively stimulating activities — playing board games, card games, reading, writing, and also dancing — can delay dementia’s onset. Knowing they’re at high risk for dementia can also help people and their families make arrangements for the future, which is an aspect of MCR testing that I’ve found is very important in my own clinical practice.”