To that end, a new study finds that children with older fathers are more susceptible to mental health disorders.
An international team of researchers lead by Dr. John McGrath of Queensland Brain Institute’s (QBI), used Danish health registers to examine the maternal and paternal age of 2,894,688 offspring at birth.
“The study followed people with a a broad range of mental disorders including schizophrenia, mood disorders, neurotic, stress-related, eating disorders, personality disorders and a range of developmental and childhood disorders born from 1955 to 2007.
“The research method is the equivalent of 42.7 million person years,” McGrath said.
“We found that the overall risk for psychiatric disorders, in particular mental retardation, autism and schizophrenia, increased for those born to a father over the age of 29 years.”
The association between parental age and risk of mental disorders in offspring may be confounded by a range of factors.
“De novo (or new) mutation in the developing sperm cell may contribute to an increased risk for a surprisingly wide range of mental health disorders, including schizophrenia, autism and mental retardation.”
Analysis of the data also confirmed a link between the offspring of younger mothers and substance abuse disorders, hyperkinetic disorders and mental retardation.
“For the broad range of neurotic and stress related disorders, the offspring of teenaged mothers were at the highest risk,” said researchers.
The study is published in JAMA Psychiatry.
“Recent genetic studies have confirmed that the offspring of older fathers have more de novo mutations.
“Our new studies suggest that age-related mutations from the father may impact on the mental health of the offspring.”
In short, the biological clock ticks for men, as well as women.
In addition to the recent attention to the risk for mental disorders in the offspring of older fathers, the study demonstrates a more complex and nuanced pattern of association between maternal and paternal ages and the risk for mental disorders in their offering.
Source: University of Queensland