Hospital-diagnosed maternal bacterial infections during pregnancy have been linked with an increased risk of autism spectrum disorders in children, according to a new study.
“Though infections in pregnant women are fairly common, in this study most were not associated with an increased risk of autism,” said Lisa A. Croen, Ph.D., a research scientist with the Kaiser Permanente Division of Research and senior author of the study.
“Only bacterial infections diagnosed in the hospital were associated with an increased risk.”
The study, published in the Journal of Autism and Developmental Disorders, included 407 children with autism and 2,075 matched children who did not have autism.
The study examined infants born between January 1995 and June 1999 who remained members of the organization’s health plan for at least two years following birth.
The study found that women with bacterial infections diagnosed during a hospitalization had a 58 percent greater risk of having a child with an ASD.
While not very common in any of the mothers studied — 1.5 percent of mothers of a child with ASD vs. 0.5 percent of mothers of a child without ASD — infections diagnosed during a hospitalization in the second trimester were associated with children having more than a three-fold increased risk of developing ASD, the researchers said.
“Infections diagnosed in an inpatient setting may represent more severe infections, and these were associated with increased risk of ASD,” said Ousseny Zerbo, Ph.D., a research fellow and the study’s lead author.
While the mechanism for how maternal infections may influence autism risk has not been established, Zerbo said animal tests have shown that immune-system responses to infections during pregnancy may influence the neurological development of the fetus.
“Our findings indicate that although most infections during pregnancy were not associated with autism in the child, there appears to be some increased risk for autism,” Zerbo said.
“It would be prudent for pregnant women to contact their doctor if they suspect an infection.”
Source: Kaiser Permanente