Researchers have long observed a correlation between moderate amounts of alcohol consumption, enhanced cardiovascular function and generally better overall health. But a true cause-and-effect relationship between alcohol and health, however, is still debated.
New research may add weight to the medicinal value of alcohol as lab research suggests moderate drinking may boost the immune system and help it fight off infection.
Researchers from Oregon Health & Science University have published their findings in the journal Vaccine.
Investigators say their findings improve knowledge on the method by which the human body responds to vaccines and infections.
The scientists did their research on rhesus macaques, which have an immune system very similar to humans.
To conduct the study, the researchers trained a group of 12 rhesus macaques to consume alcohol — a 4 percent ethanol mixture — of their own accord.
Researchers vaccinated the monkeys against smallpox as part of the study. They then separated the animals into two groups — those with access to the 4 percent ethanol and those with access to sugar water.
All of the animals had regular access to pure water, and to food. The researchers then monitored the animals’ daily ethanol consumption for 14 months. And the animals were vaccinated again, seven months after the experiment began.
“Like humans, rhesus macaques showed highly variable drinking behavior,” said Ilhem Messaoudi, Ph.D., lead author of the paper.
“Some animals drank large volumes of ethanol, while others drank in moderation.”
The monkeys’ voluntary ethanol consumption segregated them into two groups.
One group was made up of heavy drinkers, those that had an average blood ethanol concentration greater than 0.08 percent — the legal limit for humans to be able to drive a vehicle.
The other group was made up of moderate drinkers, with an average blood ethanol concentration of 0.02 to 0.04 percent.
Prior to consuming the alcohol, all of the animals showed comparable responses to the vaccination. But after exposure to the alcohol, the two groups of monkeys responded in very different ways to the vaccination.
The heavy drinkers showed greatly diminished vaccine responses compared with the control group of monkeys who drank the sugar water.
But the more surprising finding: The moderate-drinking monkeys displayed enhanced responses to the vaccine compared to the control group.
Moderate drinking bolstered their bodies’ immune systems.
“It seems that some of the benefits that we know of from moderate drinking might be related in some way to our immune system being boosted by that alcohol consumption,” said Kathy Grant, Ph.D., a senior author on the paper.
The researchers stressed that excessive alcohol consumption was injurious to the monkeys’ immune systems — just as excessive alcohol consumption is bad for human bodies in many ways.
“If you have a family history of alcohol abuse, or are at risk, or have been an abuser in the past, we are not recommending you go out and drink to improve your immune system,” Messaoudi said.
“But for the average person who has, say, a glass of wine with dinner, it does seem in general to improve health and cardiovascular function. And now we can add the immune system to that list.”
The next steps for the researchers will be to better understand why the immune system reacts as it does to moderate alcohol. That may lead to a pharmaceutical alternative that could provide the same benefits as the moderate alcohol consumption.