Researchers evaluated the offspring of a large cohort of pregnant women who participated in the Child Health and Development Study (CHDS) from 1959-1966.
The study was based on 79 cases and 654 comparison subjects. Maternal smoking during pregnancy was associated with a twofold increased risk of BD in their offspring.
Expert are aware that smoking during pregnancy contributes to significant problems in utero and following birth, including low birth weight and attentional difficulties.
However, this is the first study to suggest an association between prenatal tobacco exposure and the BD, say the authors.
Bipolar disorder (BD) is a serious psychiatric illness marked by significant shifts in mood that alternate between periods of depression and mania. Symptoms typically become noticeable in the late teens or early adulthood.
“These findings underscore the value of ongoing public health education on the potentially debilitating, and largely preventable, consequences that smoking may have on children over time,” said Alan Brown, M.D., M.P.H.
The authors wrote: “Much of the psychopathology associated with prenatal tobacco exposure clusters around the ‘externalizing’ spectrum, which includes attention deficit hyperactivity disorder (ADHD), oppositional defiant disorder (ODD), conduct disorder (CD), and substance abuse disorders.
“Although not diagnostically classified along the externalizing spectrum, BD shares a number of clinical characteristics with these disorders, including inattention, irritability, loss of self-control, and proclivity to drug/alcohol use.”
In effect, children who were exposed to tobacco smoke in utero may exhibit some symptoms and behaviors that are found in BD.
A previous study by Brown and colleagues found that flu virus in pregnant mothers was associated with a fourfold increased risk that their child would develop BD.
Research findings are published in the American Journal of Psychiatry.