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Body Obsession Linked to Disordered Brain Wiring

By Senior News Editor
Reviewed by John M. Grohol, Psy.D. on April 30, 2013

Body Obsession Linked to Disordered Brain WiringIn a new study, Jamie Feusner, M.D., and colleagues report that individuals with body dysmorphic disorder (BDD) have, in essence, global “bad wiring” in their brains — that is, there are abnormal network-wiring patterns across the brain as a whole.

BDD sufferers feel they are disfigured and ugly, even when they look normal to others. The discovery that abnormal connections between regions of the brain lead to problems in visual and emotional processing builds upon earlier research.

The findings, published in the May edition of the journal Neuropsychopharmacology, suggest that these patterns in the brain may relate to impaired information processing.

“We found a strong correlation between low efficiency of connections across the whole brain and the severity of BDD,” Feusner said. “The less efficient patients’ brain connections, the worse the symptoms, particularly for compulsive behaviors, such as checking mirrors.”

People suffering from BDD tend to fixate on minute details, such as a single blemish on their face or body, rather than viewing themselves in their entirety.

They become so distressed with their appearance that they often can’t lead normal lives, are fearful of leaving their homes and occasionally even commit suicide.

Patients frequently have to be hospitalized. BDD affects approximately 2 percent of the population and is more prevalent than schizophrenia or bipolar disorder. Despite its prevalence and severity, scientists know relatively little about the neurobiology of BDD.

In the current study, Feusner and his colleagues performed brain scans of 14 adults diagnosed with BDD and 16 healthy controls. The goal of the study was to map the brain’s connections to examine how the white-matter networks are organized.

White matter is made up of nerve cells that carry impulses from one part of the brain to another.

Researchers used a sensitive form of brain imaging called diffusion tensor imaging, or DTI to perform the study. DTI is a variant of magnetic resonance imaging that can measure the structural integrity of the brain’s white matter.

From these scans, they were able to create whole brain “maps” of reconstructed white-matter tracks. Next, they used a form of advanced analysis called graph theory to characterize the patterns of connections throughout the brains of people with BDD and then compared them with those of healthy controls.

The researchers found people with BDD had a pattern of abnormally high network “clustering” across the entire brain. This suggests that these individuals may have imbalances in how they process “local” or detailed information.

During the research, investigators discovered specific abnormal connections between areas involved in processing visual input and in brain regions involved in recognizing emotions.

“How their brain regions are connected in order to communicate about what they see and how they feel is disturbed,” said Feusner.

“Their brains seem to be fine-tuned to be very sensitive to process minute details, but this pattern may not allow their brains to be well-synchronized across regions with different functions,” he said. “This could affect how they perceive their physical appearance and may also result in them getting caught up in the details of other thoughts and cognitive processes.”

Feusner says the study advances the understanding of BDD by providing evidence that the “hard wiring” of patients’ brain networks is abnormal.

“These abnormal brain networks could relate to how they perceive, feel and behave,” he said. “This is significant because it could possibly lead to us being able to identify early on if someone is predisposed to developing this problem.”

Source: UCLA

Abstract of brain networking photo by shutterstock.

 

APA Reference
Nauert, R. (2013). Body Obsession Linked to Disordered Brain Wiring. Psych Central. Retrieved on October 30, 2014, from http://psychcentral.com/news/2013/04/30/body-obsession-linked-to-disordered-brain-wiring/54313.html