Daily Drinking Can Reduce New Brain Cells in Mice
A new Rutgers University rodent study indicates there is a fine line between moderate and binge drinking, a risky behavior that can decrease the number of new adult brain cells by as much as 40 percent.
The researchers reported that moderate to binge drinking — drinking less during the week and more on the weekends — significantly reduces the structural integrity of the adult brain.
“Moderate drinking can become binge drinking without the person realizing it,” said lead author Megan Anderson, a graduate student working with Dr. Tracey J. Shors, a professor in the Department of Psychology.
“In the short term there may not be any noticeable motor skills or overall functioning problems, but in the long term this type of behavior could have an adverse effect on learning and memory.”
Shors and Anderson worked with postdoctoral fellow Miriam Nokia, Ph.D. to model moderate to heavy drinking using rodents that reached a blood alcohol level of 0.08 percent — the legal driving limit in the United States and many other countries — and found that brain cell production was affected negatively.
The researchers discovered that at this level of intoxication in rats — comparable to about three to four drinks for women and five drinks for men — the number of nerve cells in the hippocampus were reduced by nearly 40 percent compared to those in the abstinent group of rodents.
The hippocampus is a part of the brain where new neurons are made and is also known to be necessary for some types of new learning, the researchers explain.
This level of alcohol intake was not enough to impair the motor skills of any of the rats or prevent them from associative learning in the short term, the researchers note.
But they add that this substantial decrease in brain cell numbers over time could have profound effects on the structural plasticity of the adult brain because these new cells communicate with other neurons to regulate brain health.
“If this area of your brain was affected every day over many months and years, eventually you might not be able to learn how to get somewhere new or to learn something new about your life,” said Anderson. “It’s something that you might not even be aware is occurring.”
According to the National Institute of Alcohol Abuse and Alcoholism, men who drink 14 drinks a week and women who drink seven are considered at-risk drinkers.
Although college students commonly binge drink, according to the institute, 70 percent of binge drinking episodes involved adults age 26 and older.
“This research indicates that social or daily drinking may be more harmful to brain health than what is now believed by the general public,” she said.
The study is scheduled to be published in the journal Neuroscience.
Wood, J. (2012). Daily Drinking Can Reduce New Brain Cells in Mice. Psych Central. Retrieved on July 29, 2015, from http://psychcentral.com/news/2012/10/30/daily-drinking-can-reduce-new-brain-cells-in-mice/46873.html