Rat Study Suggest Binge Eating Can Trigger Addictive Behaviors
Researchers believe that individuals with a record of binge eating may also present additional addiction-like behaviors.
Substance abuse is a common complement to binge eating, according to Penn State College of Medicine researchers. Investigators believe this finding may help to illuminate factors that promote substance abuse, addiction, and relapse.
“Drug addiction persists as a major problem in the United States,” said Patricia Sue Grigson, Ph.D. “Likewise, excessive food intake, like binge eating, has become problematic. Substance-abuse and binge eating are both characterized by a loss of control over consumption.
“Given the common characteristics of these two types of disorders, it is not surprising that the co-occurrence of eating disorders and substance abuse disorders is high. It is unknown, however, whether loss of control in one disorder predisposes an individual to loss of control in another.”
In the lab, Grigson and her colleagues found a link between bingeing on fat and the development of cocaine-seeking and -taking behaviors in rats.
This relationship suggests that conditions promoting excessive behavior toward one substance can increase the probability of excessive behavior toward another.
The findings are reported in the journal Behavioral Neuroscience.
To test if a history of binge eating on fat would augment addiction-like behavior toward cocaine, researchers provided the rats four different diets: normal rat chow; continuous access to an optional source of dietary fat; one hour of access to optional dietary fat daily; and one hour of access to dietary fat on Mondays, Wednesdays, and Fridays.
All four groups also had unrestricted access to nutritionally complete chow and water. The researchers then assessed the cocaine-seeking and -taking behaviors.
“Fat bingeing behaviors developed in the rats with access to dietary fat on Mondays, Wednesdays, and Fridays — the group with the most restricted access to the optional fat,” Grigson said.
This group tended to take more cocaine late in training, continued to try to get cocaine when signaled it was not available, and worked harder for cocaine as work requirements increased.
“While the underlying mechanisms are not known, one point is clear from behavioral data: A history of bingeing on fat changed the brain, physiology, or both in a manner that made these rats more likely to seek and take a drug when tested more than a month later,” Grigson said. “We must identify these predisposing neurophysiological changes.”
While the consumption of fat in and of itself did not increase the likelihood of subsequent addiction-like behavior for cocaine, the irregular binge-type manner in which the fat was eaten proved critical.
Rats that had continuous access to fat consumed more fat than any other group, but were three times less likely to exhibit addiction-like behavior for cocaine than the group with access only on Mondays, Wednesdays and Fridays.
“Indeed, while about 20 percent of those rats and humans exposed to cocaine will develop addiction-like behavior for the drug under normal circumstances, in our study, the probability of addiction to cocaine increased to approximately 50 (percent) for subjects with a history of having binged on fat,” Grigson said.
Researchers say additional studies will investigate in more detail how bingeing can lead to addiction-like behaviors.
Source: Penn State University
Nauert PhD, R. (2012). Rat Study Suggest Binge Eating Can Trigger Addictive Behaviors. Psych Central. Retrieved on October 6, 2015, from http://psychcentral.com/news/2012/04/25/rat-study-suggest-binge-eating-can-trigger-addictive-behaviors/37798.html