As researchers intensify their investigation into the root cause for autism, experts are viewing the developmental disorder as arising from both genetic and environment factors.
The serious developmental disorder affects nearly one in 100 children.
In a new study, investigators believe they have confirmed that low birth weight is an important environmental factor contributing to the risk of autism spectrum disorder (ASD).
Researchers studied a unique population, twin pairs in which only one of the twins was affected by ASD.
“Our study of discordant twins found birth weight to be a very strong predictor of autism spectrum disorder,” said Northwestern University researcher Molly Losh, Ph.D. Losh is lead author of the study that will be published in the journal Psychological Medicine and is now available online.
Prior twin studies have shown that when one identical twin had ASD, the other twin was much more likely to have ASD than not.
“Because identical twins share virtually 100 percent of their genes, this is strong evidence for the role of genetics in autism,” said Losh. “Yet it is not 100 percent the case that ASD affects both identical twins in a twin pair.”
“That only one twin is affected by ASD in some identical twin pairs suggests that environmental factors may play a role either independently or in interaction with autism risk genes,” she added.
“And because autism is a developmental disorder impacting brain development early on, it suggests that prenatal and perinatal environmental factors may be of particular importance.“
During the study, researchers found that lower birth weight more than tripled the risk for autism spectrum disorder in identical twin pairs in which one twin had ASD and the other did not.
An innovative study methodology was used to control for shared genetic and environmental factors as researchers used a co-twin control study design in which the ASD-affected twin served as the case and the unaffected twin served as the control.
Investigators found the risk for autism spectrum disorder rose 13 percent for every 100 gram- (3.5 ounce-) decrease in birth weight.
“There’s been a great deal of misinformation about the causes of autism — from the 1950s misconception that the distant maternal behavior of what were dubbed ‘refrigerator mothers’ was at fault to the ill-informed myth that vaccines can cause autism,” said Losh.
Losh and her colleagues’ findings add to a growing body of knowledge about the complex causes of autism and suggest that birth weight could be one of the environmental features that interacts with underlying genetic predisposition to autism.
Losh cautioned that the findings from twin studies might not extend to singletons, as the prenatal and perinatal conditions for twins and singletons differ in important ways.
For the study, researchers followed a population-based sample of 3,725 same-sex twin pairs that were part of the Swedish Twin Registry’s Child and Adolescent Twin Study. The discordant twins they studied were pairs in which one twin was more than 400 grams (about 14 ounces) or at least 15 percent heavier at birth than the other.
Source: Northwestern University