A team from the University of Warwick has found that depression frequently appears to uncouple the brain’s “hate circuit.”
Led by Prof. Jianfeng Feng, the researchers used functional magnetic resonance imaging (fMRI) scanners to scan the brain activity in 39 depressed people and 37 control subjects who were not depressed.
The researchers found the fMRI scans revealed significant differences in the brain circuitry of the two groups. The greatest difference observed in the depressed patients was the uncoupling of the so-called “hate circuit” involving the superior frontal gyrus, insula and putamen. Other major changes occurred in circuits related to risk and action responses, reward and emotion, attention and memory processing.
The hate circuit was first clearly identified in 2008 by Prof. Semir Zeki of University College London who found that a circuit which seemed to connect three regions in the brain (the superior frontal gyrus, insula and putamen) when test subjects were shown pictures of people they hated.
The new University of Warwick led research found that in significant numbers of the depressed test subjects they examined by fMRI, the hate circuit had become decoupled. Those depressed people also seemed to have experienced other significant disruptions to brain circuits associated with risk and action, reward and emotion, and attention and memory processing. The researchers found that in the depressed subjects:
Feng said that “the results are clear but at first sight are puzzling as we know that depression is often characterized by intense self-loathing and there is no obvious indication that depressives are less prone to hate others.”
“One possibility is that the uncoupling of this hate circuit could be associated with impaired ability to control and learn from social or other situations which provoke feelings of hate toward self or others. This in turn could lead to an inability to deal appropriately with feelings of hate and an increased likelihood of both uncontrolled self-loathing and withdrawal from social interactions.
“It may be that this is a neurological indication that is more normal to have occasion to hate others rather than hate ourselves.”
The study, titled “Depression Uncouples Brain Hate Circuit,” was published Oct. 4, 2011 in the journal Molecular Psychiatry.
Source: University of Warwick