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Lead May Be Linked to ADHD

By Senior News Editor
Reviewed by John M. Grohol, Psy.D. on January 29, 2010

Lead May Be Linked to ADHDAccording to the Centers for Disease Control (CDC) the diagnosis of ADHD increased an average of 3 percent per year from 1997 to 2006. The disorder affects more than 5 percent of the population and is among the costliest of behavioral disorders.

Although the cause of ADHD remains unknown, recent studies have focused on heredity with genetics suspected to account for 70 percent of ADHD among children.

Emerging research also suggest an environmental link for ADHD with some experts believing lead may be a culprit.

Lead is a neurotoxin. This has been known for a long time, and in fact government regulation drastically reduced environmental lead a generation ago. But regulating automobile fuel and paint didn’t entirely eliminate lead from the environment.

It’s found in trace amounts in everything from children’s costume jewelry to imported candies to soil and drinking water. Every American today is exposed to low levels of the metal, and indeed nearly all children have measureable levels of lead in their bodies.

According to psychological scientist Joel Nigg of the Oregon Health & Science University, this universal low-level exposure makes lead an ideal candidate for the disorder’s trigger.

This was just a theory until quite recently, but two recent studies now provide strong evidence. The first study compared children formally diagnosed with ADHD to controls, and found that the children with the disorder had slightly higher levels of lead in their blood.

This study showed a link only between blood lead and hyperactivity/impulsivity symptoms, not inattention. But a second study showed a robust link between blood lead and both parent and teacher ratings of ADHD symptoms, including both hyperactivity and attention problems.

In both studies, the connection was independent of IQ, family income, race, or maternal smoking during pregnancy.

Nigg offers a causal model for the disabling symptoms associated with ADHD: Lead attaches to sites in the brain’s striatum and frontal cortex, where it acts on the genes in these regions—causing them to turn on or remain inactive.

Gene activity shapes the development and activity of these brain regions. By disrupting brain activity, the toxin in turn alters psychological processes supported by these neurons, notably cognitive control. Finally, diminished cognitive control contributes to hyperactivity and lack of vigilance.

Nigg describes his new data and his explanatory model in the February issue of the journal Current Directions in Psychological Science.

Source: Association for Psychological Science

 

APA Reference
Nauert, R. (2010). Lead May Be Linked to ADHD. Psych Central. Retrieved on December 22, 2014, from http://psychcentral.com/news/2010/01/29/lead-may-be-linked-to-adhd/11058.html