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Generic Name: Olanzapine and Fluoxetine HCl capsules
(oh LAN za peen and floo OX eh teen)

Drug Class: Antidepressant, SSRI

Table of Contents







Symbyax (Olanzapine and Fluoxetine HCl capsules) is a prescription antidepressant and antipsychotic medication. It is a selective serotonin reuptake inhibitor (SSRI) used to treat adult depression caused by bipolar disorder (manic depression). It is also used to treat depression after at least 2 other medications have been tried without successfully treating your symptoms.

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

It works by helping change certain chemicals in the brain, which professionals refer to as “neurotransmitters.” It is not yet well-understood why changing these neurochemicals results in symptom relief for the conditions this drug is commonly prescribed for.

How to Take It

Take Symbax exactly as instructed by your doctor.

Side Effects

Side effects that may occur while taking this medicine include:

  • changes in weight, weight gain
  • diarrhea
  • sore throat
  • dry mouth
  • drowsiness
  • lightheadedness
  • tremors (shakes)
  • weakness

Contact your doctor immediately if you experience:

  • swelling of face, hands and feet
  • delusions
  • nervousness
  • memory loss
  • vomiting blood
  • cold symptoms, e.g. cough/congestion/runny nose
  • fever
  • headache
  • extreme stomach pain
  • tingling in hands or feet
  • quick weight gain
  • vision changes
  • swollen glands in neck
  • difficulty speaking
  • uncontrolled twisting movements
  • ear pain

Warnings & Precautions

  • DO NOT take this medicine if you are taking a monoamine oxidase inhibitor (MAOI) or have stopped taking a MAOI within the last 2 weeks.
  • DO NOT give this medicine to a child under the age of ten years old.
  • DO NOT take this medicine if you are currently using methylene blue injections, allergic to olanzapine or fluoxetine or if you also take pimozide or thioridazine.
  • Tell your doctor if you have diabetes, a blood clotting disorder, a history of drug abuse, seizures, liver disease, or severe consipation.
  • This medicine may cause drowsiness, dizziness or lightheadedness. DO NOT drive, operate machinery, or do anything else that could be dangerous until you know how you react to this medicine.
  • Tell your doctor if you experience impulsivity or irritability, or agitation, behavior or mood changes, anxiety, or panic attacks. Let your doctor know if you have trouble sleeping, are hyperactive (mentally or physically), hostile, aggressive, restless, more depressed, or if you are thinking about hurting yourself.
  • Alcoholic beverages can increase the effects of this medicine and should be avoided.
  • For an overdose, seek medical attention immediately. For non-emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products. Do not take Symbyax if you are taking Mellaril (thioridazine) or a monoamine oxidase inhibitor (MAOI).

Dosage & Missed Dose

Follow your doctor’s directions exactly and follow your prescription label. Your dose may be changed by your doctor to ensure the best results. Do not take this medicine in larger or smaller amounts, or for longer than recommended.

You do not need to consume food when you take olanzapine and fluoxetine. This medicine should be taken at the same time each day.

Olanzapine can cause high blood sugar /hyperglycemia. Check your blood sugar levels regularly if you are diabetic while taking this drug.

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


If you plan on becoming pregnant, discuss with your doctor the benefits and risks of using this medicine during pregnancy. It is NOT known if this medicine is excreted in breast milk. It is recommended that you DO NOT breastfeed while taking this medicine unless your doctor or pediatrician has told you to.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website,  for additional information from the manufacturer of this drug.



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APA Reference
Psych Central. (2018). Symbyax. Psych Central. Retrieved on October 26, 2020, from


Scientifically Reviewed
Last updated: 8 Oct 2018
Last reviewed: By Christine Traxler, M.D.
Published on All rights reserved.