Generic Name: Desvenlafaxine (des VEN la FAX een)

Drug Class: Serotonin-Norepinephrine Reuptake Inhibitor (SNRI)

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Pristiq (Desvenlafaxine) is an antidepressant in used to treat major depressive disorder. It belongs to a group of drugs called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). This medication affects chemicals in the brain that be unbalanced in people with depression.

It works by restoring the balance of certain naturally-occuring substances in the brain (serotonin and norepinephrine).

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

How to Take It

Take this medicine as directed. It can be taken with or without food. Do not stop taking this medicine abruptly without consulting with your doctor.

Side Effects

Side effects that may occur while taking this medicine include:

  • excessive sweating
  • nervousness
  • vertigo
  • dizziness
  • chills
  • unusual dreams
  • blurred vision

Contact your doctor if you experience symptoms that become bothersome, including:

  • severe headache
  • difficulty urinating
  • rash
  • trouble speaking
  • seizures
  • uncontrollable shaking
  • confusion
  • fever
  • changes in sexual ability

Warnings & Precautions

  • If you have taken an MAO inhibitor in the past two weeks, DO NOT not use Pristiq. A dangerous drug interaction could occur.
  • Pristiq may raise your blood pressure. Check your blood pressure regularly and inform your physician if the results are high.
  • Inform your doctor or dentist that you are taking this drug if you are having any type of surgery.
  • Seek medical attention immediately if you experience serious side effects, including eye pain or swelling, persistent cough, black stools, shortness of breath, chest pain, vomit that looks like coffee grounds, change in the amount of urine, seizures, or any vision changes.
  • Talk to your doctor about having an eye examination before you start taking this medication. Desvenlafaxine may cause angle-closure glaucoma, a condition which may lead to a loss of vision.
  • For an overdose, seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Before taking any new medicine, either prescription or over-the-counter, check with your doctor or pharmacist. This includes supplements and herbal products.

Dosage & Missed Dose

Follow all directions exactly as prescribed by your doctor. The recommended dose is 50 mg daily. This medication should be swallowed whole.

Do not chew, crush, or dissolve this medication in water. Doing so can release all of the drug at once, increasing the risk of side effects. Do not split the tablets unless advised by your doctor to do so.

If you skip a dose, take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses or take extra medicine to make up for the missed dose.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (preferably not in the bathroom). Throw away any medication that is outdated or no longer needed.


This medication should only be used when necessary. Taking this medication, particularly in the last three months of pregnancy, can muscle stiffness, constant crying, drowsiness, or feeding or breathing difficulties in a newborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

This medication passes into breast milk and could have harmful effects on a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

More Information

For more information, talk to your doctor, pharmacist or health care provider, or you can visit this website:


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