My old hometown newspaper, The News Journal (Wilmington, Del.) had a nice write-up of Seroquel’s big explosion in prescriptions over the past decade. Seroquel is made by one of Delaware’s biggest private employers, AstraZeneca, hence the local angle.
But …
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This all obscures the bigger points.
One of the main reasons that psychiatrists hesitate to prescribe typical antipsychotics is because of the increased risk of Tardive dyskinesia (TD). CATIE was too short to evaluate the comparative TD risk of the antipsychotics, especially since pts with pre-existing TD were not assigned to the typical antipsychotic group in the trial.
So the devil you know is worse than the one you don’t?
It seems odd to make prescribing decisions based upon a lack of data (knowledge).
And, in fact, there are signs that the atypicals may have some of the same problems long term (see, for example, Catena Dell’osso et al. (2007). Newer antipsychotics and the rabbit syndrome. Clin Pract Epidemol Ment Health, 3:6).
Then it becomes a question of which is a greater health (or mortality) risk — diabetes or TD?
Sir,
Is there any alternative to psychiatry for the mentally ill? NO.68% of FDA budget is provided by Drug MNCs like JJ,Eli LILLY,novartis,astrazenca etc etc.
It requires a psychiatrist to say after earning his SECURITY of home and future and now i will tell the truth to the world.
CATTIE studies was flawed from the beginning due to absence of CLOZAPINE in the list of drugs.I have asked many psychiatrists why you give clozapine as the last resort instead of giving it in the first place itself in low dosage and gradually increasing the dosage when relapse happens.they DO NOT give convincing answer.
In fact this utter lack of HONESTY among the psychiatric community has produced a community called PSYCHIATRIC SURVIVORS who invade third world countries as their home country has no use for them.