No, not yet.
But the U.S. Food and Drug Administration (FDA) today notified the maker of Singulair, a popular drug used to treat asthma, that it wanted more information and data about its use and suicide and suicidal thoughts.
According to a report at WebMD, “In response to inquiries received by the FDA, the FDA has asked Merck to evaluate Singulair study data for more information about suicidality and suicide. The FDA is also reviewing its postmarketing reports of behavior/mood changes, suicidality, and suicide in patients who took Singulair.”
The FDA said it is also reviewing reports of behavioral changes in patients taking similar drugs, including AstraZeneca Plc’s Accolate and Critical Therapeutics Inc’s Zyflo, but has not yet decided whether further investigation is needed.
All three drugs are known as leukotriene agents that work by controlling leukotrienes — chemicals in the body that are released during an allergic reaction and can lead to inflammation, congestion and other symptoms.
In a statement, Merck said its analysis of more than 11,000 patients in 40 clinical trials of Singulair found no reported suicides or suicidal thoughts or behavior.
The FDA suggested no one should go off of their medication before first talking to their doctor. Doctors should more closely monitor patients on one of these drugs for changes in mood or behavior, especially related to suicidal thoughts (especially in people who have no prior history of having any).
You can read more about the issue from this Reuters report on the FDA’s request about Singulair and suicide.
On April 23 2008, the FDA approved changes Merck made to the package insert that mentions agitation, depression, irritability and “suicidal thinking and behavior (including suicide).” The information is also on a Singulair website, but some pharmacists still dispense from older shipments delivered before the label changes.
On May 3 2008, The (Albany) Times Union published this account that stated:
FDA officials will collect personal stories of people experiencing unusual side effects while taking the allergy drug Singulair, a move that follows a meeting Friday with a Queensbury couple who blame the medication for prompting their son’s suicide.
This entry was posted on Thursday, March 27th, 2008 at 6:49 pm and is filed under General, Medications, Depression, Health-related. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.
45 Responses to “Asthma + Singulair = Suicide?” (Pingbacks/trackbacks not shown below)
I have twin sons who have taken Singulair in the past, one of whom is currently taking it. Neither of them have ever had any of these symptoms. Singulair has worked wonders for both their allergy and asthma symptoms without side effects such as agitation, anger, or sleep disturbances.
Anyone can have a bad reaction to any drug. It’s a shame that an adverse reaction in such a tiny fraction of the number of people who take it can give a medication that works so well for so many a bad name.
Pennsylvania at 2:37 pm on
March 28th, 2008
My son has been taking singulair for asthma since he was 3. He is my only boy and I really can not say for sure if his behavior is related to the drug or not. He does seem to get very angry at times (compared to the way my daughter might react) but he surely needs to take something to keep his asthma under control and the other drugs also have reports of side effects. I called the doctor’s office today to see if he should stop taking the drug and they said he should continue. It is a hard decision because I need him to stay healthy. He is 9 now and I do think his behavior at times is hard to control. I (again) can not be sure it is related to the drug but it certainly is soemthing to think about. I hope they complete their investigation sooner than 9 months.
Elmo at 6:29 am on
March 29th, 2008
My son is 19 and has had respiratory problems almost all his life. When he was 5 he was diagnosed with asthma. Thanks to the American Lung Association, we were able to start the process of learning about asthma and the management of asthma. We learned about triggers and how to avoid them. We learned about subclinical symptoms and how to recognize them in advance of a full blown asthma attack. One of the subclinical symptoms in our son was irritability — some people would have called it anger but I don’t think that it ever rose to that level.
He started taking Singulair several years ago — not to deal with asthma but with an underlying allergic rhinitis which results in inflamed sinuses which have always been one of his triggers. It makes a huge difference. Aside from normal teenage angst, I don’t think he has had any suicidal tendencies. I pointed out the news article to him so that he would be aware of the possible potential. He snorted and made a rude remark about people who want to find something to blame things on.
Los Angeles at 8:19 pm on
March 29th, 2008
My son started taking Singulair two years ago. The changes I have noticed in him are disturbing. He was always a gentle, smart boy who loved music. He was quick to laugh and had many friends. This past year he began to isolate himself. He no longer wanted play dates and would frequently cry for no reason. He developed insomnia and on the weekends was hard to rouse and sometimes slept as late as one PM. He talked about how he wanted to be alone and said he wanted to live on the street, away from his family. I could go on and on about the inexplicable, negative changes in my son. I told myself maybe it was just adolescence come early. He seemed so miserable and would no longer play with his younger brother when just a year or more ago they were inseparable. The most shocking thing is a few days ago I found a poem he had written, talking about how the world was a horrible place and it might be better if he died and flew away. You can imagine how heartbreaking it is to read something like this from a once happy, adored 10 year old. Just a day later I heard the news about Singulair causing suicidal thoughts. I immediately pulled him off the medication and the improvement in his mood already is enormous. I am fighting mad! Who would think an allergy medication would make a child’s world black and full of despair? It makes me sick to remember how every night I would remind him to take his Singulair thinking I was protecting him. Are there other children out there who have developed mood disorders and are taking this poison? I want to join a class action lawsuit. What can parents do to stop things like this happening again?
paula neer at 12:25 am on
March 30th, 2008
Hi, I am 47 yo and have had serious asthma for about 10 years now, after moving to the houston, texas, area obviously, my respiratory conditions worsened. I also suffer from depression and am on Effexor XR, which up until the last two months and starting again two days ago I believe is the best anti depressant on the market (for myself anyway). My Dr. prescribed Singulair May of 07 and I took it for several months, my older sister told me she had stopped taking it because she thought it had made her worse and I certainly wasn’t getting any better, so I stopped also. However, I came down with Pneumonia in September and blood work showed I was unable to fight my allergies, back on Singulair I went. I couldn’t seem to get back to myself, but I assumed it was from being ill for 2 months and off work. (I haven’t been to work on time since December of 07, no matter how much sleep I get, it is never enough.) However, the last two months and especially the last 2 weeks, anything negative has made me think of dying. All of my asthma meds have ruined my teeth & on Monday my dentist told me I would have to have dentures, when I left, the office staff was afraid I was going to kill myself. I went to Walmart this last Wednesday and when I was walking to my car I was short winded and tired and thought: “I’m 47, my teeth are gone, my lungs are shot, what’s the point in living?” I truly wanted to give up. This was a truly, profound thought. I believe Paul Harvey saved my life. The next morning (Thursday, 3/27/08) I heard the relation between Singulair and suicide, I stopped taking it immediately. It’s only been 2 days, but it gives me hope that my mind will improve, that I can focus and think clearly, that I will be successful at the job I have been at for 14 years again, that I can have a clean home again, enjoy life again, stop thinking about dying and start wanting to live. Sorry if I rambled, I just want to know how to get in touch with Merck or the FDA to tell them all of this.
TJohnson at 11:38 am on
March 31st, 2008
I have been diagnosed with asthma since I was 14 years old, I am now 30. I have been on Singulair for just about 2 years and it has been 2 years of complete hell. My husband, bless his heart, has stuck through what we throught were hormonal instances (yeah, for 2 years???). I have been on different birth control thinking that was the issue, I have had rage fits, paranoid feelings, anxiety attacks, depression, fits of crying uncontrollably. Mind you, I have NEVER been this way in my life, besides the little up and down you get from your monthly cycle. Life has been horrible for 2 years, not because of me, my husband, or my step daughter, but because of this medicine. My husband told me about this on Friday and I literally wanted to break down in tears, finally…an answer to the craziness that was never in my life before! Even planning my wedding was affected by this nasty pill. I went off of this medicine immediately at the discresion of my doctor and I will never go on it again. I do have a hard time breathing and I was put on zyrtec instead of claritin-d (blood pressure issues), and I hope I’ll be able to find relief for my breathing in the near future. Until then, my inhaler will work just fine. BEWARE OF THIS DRUG!!!! Especially if you have a tendency to be more sensitive to medications than others. This can happen! There are too many people that have had this happen to them, I feel the FDA should NEVER put anything on the market to be given as medications without doing their complete homework and research on the drug first.
cleo at 7:07 pm on
March 31st, 2008
My nephew takes singulair and I strongly agree that his behavior has changed. He is a straight “A” student, and for the last 4 months he has had severe behavior problems. which has never happened before. I was so concerned that I have him seeing a psych doctor. It never occurred to me that it could be has medicine. He is happy one minute and in a rage the next minute. the teacher had sent a note home that he had started cutting hisself with his scissors( just like paper cuts) and she had to take his scissors away daily. I need more information on this. He has serious alleries and asthma. It hard to control his asthma, but he is going to stop taking it. I not willing to risk it.
Lousiville Kentucky at 8:48 pm on
March 31st, 2008
My 10 year old daughter has been on singulair for two years. It has been wonderful not having the asthma attacks that used to hospitalize her for a week at a time. Yet, also for the last two years family members and myself have been trying to figure out why she gets so depressed so often. It is truly scary to find out that something you depended on to help your child may be what is hurting them. There are other medications out there to help control asthma, my childs mental health is just as important as here ability to breath. I have taken her off of Singular and am in contact with her doctor to find another option for her asthma. I want a happy and healthy child that can breath. It does’nt matter if a child has asthma when their dead. I understand alot of people have and are taking this medication. My question is will my child tell me her feelings before its to late. I’m not willing to take that risk, are you? Please listen to these warnings if you have a child on singular.
Steph at 10:56 am on
April 2nd, 2008
I’m in my late 30’s and I have taken Singulair and Zyrtec for 3 years. I have not had any thoughts of suicide or depression. I even took Singulair during pregnancy and didn’t have any suicidal thoughts, depression, or emotional outbursts. I have anxiety, but have found that Singulair doesn’t make it any worse. I’m a small person and very sensitive to most medications so I’m surprised to see this type of labeling. I think research should be done before we start condemning it.
I started taking Singulair a year ago. During the past year my depression definitely got worse. This is anecdotal, I realize, but I am not going to take Singulair any more. The SI became too strong for me to take this lightly. My pharmacist thinks that I am making too much of this story. Too bad. To err on the side of caution beats possibly losing my life to my disease.
paige at 9:07 pm on
April 2nd, 2008
I was just recently diagnoised as having ashtma. My doctor started me on singulair. I also treat depression and anxiety and have been treating with Paxil and have been doing fine for several years.
I will say that in the short time I have been taking the singulair, I have had a lot of anger, lacked control in some instances and had a hard time of letting go of the angers. I also began to isolate myself from others. Upon discussing this with my doctor, he pulled me off the drug.
Lance at 12:02 pm on
April 3rd, 2008
My 6 year old daughter has been on Singulair for about two years. In the past several months she had been getting more and more angry and irritable. If the slightest thing would not go the way she thought it sould, she would yell and stomp around and be in a horrible mood for hours. My 5 year old son refused to play with her because he said “she is too mean and will just yell at me.” We tried to find problems in school or with friends, but couldn’t find a source of her anger, frustration, and irritability. We were ready to have her start seeing a physiatrist for anxiety and depression. The problem we were struggling with is that she didn’t seem to have all the symptoms that are identified with children suffering from depression. We searched many sources regarding children and mood disorders and nothing seemed to fit.
By coincidence, we didn’t get her Singuliar prescription refilled for about a week and a half. We kept forgetting to call it in and then a few more days passed before we picked it up. Without making the connection, we noticed that she started having really good days. She wasn’t yelling, she didn’t argue and cry like she had been, and she seemed happy for a change.
The day after we started her back on the Singulair, I read the article about the FDA questioning Merck regarding Singulair. My heart skipped a beat. I e-mailed it to my wife who quickly found an online forum from parents relating eerily similar stories about their child’s behavior while taking Singulair. We have not given it to her since and we now have our happy little girl back. We’re working with her pulmonolgist to come up with an alternative, but will not giver her Singulair again.
I’m sure Singulair has worked very well for many people. But, if you or your child are taking Singulair and are having mood or behavior problems, then please talk to your doctor and look at the possibility that Singulair is the cause.
Tesa at 1:59 pm on
April 3rd, 2008
I have a 10 year old son that has been on Singulair now for 6 years…he was always a loving and caring child. He and his sister have always been very close and loving toeach other…he was like a little daddy with her, you couldn’t ask for a better big brother!! He always made good grades in school and loved school, until this past year!!! He has made a complete 360! He started haveing school phobia is what the doctors called it along with anxiety and depression…crying all the time over anything. I took him to the doctor and they dignosed him with ADHD and put him on aderal…I cried because, I never wanted to believe he needed such a drug. The Aderale has not helped anything if anything it has only made it worse. He is even more irritable than he was. I think doctors are putting children on ADHD medicine was too easily…like it solves all the problems. I am suprised to hear this about Singulair!!! It makes me very angry to think that I thought I was giving my son something that would help him to know that is is only causing him to suffer greatly!!! I have been so worried and confused about what is happening to my loving and caring son!!!! I deffinately want to join the class action law suit!!!!!!!!!!!!!!!!!!!!!!!
Tom A at 4:47 pm on
April 3rd, 2008
Just recently my daughter who is 5 has started mood changes and isolating herself more at home. I am in utter shock about the news from Merck. She started Singulair about 4 months ago because of 1 excercise induced asthma attack. She’s a loving child but recently she yells/screams at her younger brother over nothing and is decreasing her desire to do Karate which she loved dearly. Mood swings in children can be contributed to other things but when my wife mentioned about a report linking depression to Singulair I started doing my research. I read the FDA report and Merck’s response today telling me I have to wait 9 months for further studies. I am a heathcare professional and spoke to one of our Pulmonologists today but he could not offer anymore insight then what is published already but he is not taking his patients off Singulair. I am torn over what to do. I sincerly appreiate everyones comments on the website and I am surprised reading how similar my daughter sounds to your children.
Matt at 7:19 pm on
April 3rd, 2008
My 5 year old son was diagnosed with mild asthma and put on Singulair. Within a few months he began having uncontrollable fits of rage, displayed self-loathing behavior, had night terrors, and was inconsolable during these episodes. He became very destructive and was a danger to himself and our family. He even talked about killing himself and would say things like “I don’t want to be in this life anymore” and “I want to kill myself”. He would threaten my wife and his siblings and told them he wanted to kill them. It was a truly terrifying experience. Our pediatrician was clueless to these side affects and recommended we have our child go through a psychological evaluation. I knew this was not my child’s normal behavior so I searched the internet for Singulair side effects and found some message boards where parents just like me were writing about severe changes in their children’s behavior. I immediately took my son off the drug and within a couple weeks he was back to his normal self. He told us that he no longer has “that feeling inside of him”. Five year old children don’t even know what suicide is and to see my son talk like this was extremely frightening as you can imagine. He is a sweet, intelligent, loving boy who had never exhibited behavior like this until he went on Singulair. We have not seen this behavior after taking him off the drug and he has NEVER taken any other drug so it’s impossible to create that correlation with other preexisting issues. If we had listened to our pediatrician our son may have been misdiagnosed with ADHD or the like and further ruined by Ritalin or some other zombifying drug. I don’t know about you but it’s my belief that the pharmaceutical industry and practitioners in our country have already successfully created a “Prozac Nation” as I like to call it. This is dead wrong on every level.
If you go to http://www.medications.com/se/singulair you can read some of these experiences. You won’t believe what’s going on. There are over 30 pages of personal experiences on the site.
I’ve personally communicated with a leading professor of Pharmacology and Pediatrics at the University of Florida who I quote as saying “In response to your last comment, I thing Singulair has modest efficacy, and if we take all of our patients off this drug, they won’t suffer. This is not an important drug for pediatric asthma, as are inhaled corticosteroids.” Yet Singulair is the most overprescribed drug on the market today!!!!!!!!!
Christina at 8:27 pm on
April 3rd, 2008
My 8 year old son has been on singulair since he was 4. He has been much more aggressive than his older brother, with many meltdowns. At age 8, he is now depressed, suicidal, aggressive, etc. He states “I can’t control myself.” I immediately pulled him off of the singulair after the news report and he is already much happier. We haven’t had any meltdowns or crying since he came off.
I started taking Singulair in September 2007. The drug worked well to keep my asthma and allergies under control. I noticed in October 2007 that I started feeling depressed and didn’t want to do anything. I thought these feelings were related to the fact that the school district I work for was out on strike. Once I started back to work in November the feeling didn’t subside, in fact, it became worse. In December I started having feelings of anxiety. I thought the anxiety was related to some issues my husband and I were having. In January everything calmed down except for me. I started flying off the handle, accusing my husband and friends of doing things they weren’t. I had a hard time cleaning my house, dealing with my kids, and keeping up at work. Throughout February and March I got worse and worse. To the point I thought my husband and I would split up. Last week I started having serious suicidal thoughts. At this point my friend called and told me to quit taking Singulair because she heard about the suicide and behavior changes associated with this drug. I stopped taking the drug 3 days ago and I finally feel like myself after 7 months. Hopefully as this drug gets out of my system I will be my happy go lucky self again.
Kyla at 11:43 pm on
April 4th, 2008
I found out about all this in the last couple days. I have a 12 year old son who has had many of the same behaviors listed by other parents here. His grades went from all B’s to D’s and F’s, he is violent and mean to his brother, and is very detatched from me when we were always very close. I had everyone telling me it was becuase he just turned 12, but his behavior had become scarry to me with his lack of caring for anything. We are stopping the singulair as of tonight, and we’ll see if there are any changes. If not we’ll just know he is being a pre-teen. But if he goes back to who he was a year ago, then I will be very verbal about the dangers of this drug!
Our 10 year old daughter has had Asthma since she was 2 and we have tried a good deal of medications to control her condition, including Singulair. Singulair. Singular seemed to help with the asthma but it took us over a year to realize that it also caused dramatic agitation with her during bed time (about an hour after taking the meds). My husband and I thought it was defiance on her part. We elimated so many things from her diet trying to find the cause and finally figured tried the Singulair and once removed she imediately became a happy child again. Now we realize all drugs have side effects and they affect more than what is published! . Since then, were done with drugs and have significant improvement with holistic natural remedies.
What is the process for submitting complaints about side effects from a drug? when we told our doctor about the side effects they did not make a note in her file, they did not call the pharmacutical company…very interesting that there is not a system in place that we are aware???
I been on singular for almost two months,I noticed I can’t sleep actually affraid to sleep i have had this chronic cough for 10 months /w breathing problems I’m 44 and my health is going I been getting depressed becaused i been in the Emergency room 29 time since October of 2007,and not getting better, i get short winded just walking acrossed the parking lot,I don’t want to live like this,I get all kinds of bad thoughts, i wanted to leave my husband of 25 years, and accused him of cheating,i packed my house and got rid of my daughters cats.I do not like feeling like this Mean person.it seems like i feel angry mad and depressed,lost my appitite and can’t sleep.I call to make an appointment with my Doctor she recomended me to stop taking Singular.Now I need to try and save my marriage,and everyone i have been rude /mean /angry to. i hope this ugly person is gone. I don’t care for her.I want my life back too.
jeff at 9:25 pm on
April 8th, 2008
For those people that seem to be depressed on Singulair, try Zyflo cr. It is probably even more potent in severe asthma. It works differently than Singulair
CRITICAL THERAPEUTICS’ ZYFLO® RECEIVES DISTINCT CLASSIFICATION UNDER MEDICARE PRESCRIPTION DRUG BENEFIT Lexington, Mass., May 25, 2006 – Critical Therapeutics, Inc. (Nasdaq: CRTX) today announced that the Centers for Medicare and Medicaid Services (CMS) has created a unique Formulary Key Drug Type (FKDT) category for the Company’s asthma drug, ZYFLO® (zileuton tablets), under guidelines developed specifically for the Medicare Prescription Drug Benefit (Part D). This new category reflects the CMS’ adoption of the United States Pharmacopeias’ (USP) 2007 Model Guidelines. Under the new FKDT, ZYFLO is now categorized as a “Synthesis Inhibitor” based on its pharmacologic distinction from other anti-leukotriene compounds, including Merck’s Singulair®, which are grouped together in a category known as “Receptor Antagonists.” ZYFLO is the only 5-lipoxygenase (5-LO) inhibitor approved by U.S. Food and Drug Administration
christina at 10:33 pm on
April 9th, 2008
My son started taking singulair at the age of 13 after claratin became an over the counter drug.Over the years he started to have sleeping problems and was dealing with depression on a regular basis.We went to the doctors for help and were prescribed drugs for depression which he said didn’t help.He started to isolate himself from family events,dropped out of high school and started sleeping a few hours during the day because he said he couldn’t sleep at night.
On the morning on January 4th of 2006 I was informed by the local police Dept when I reported my son missing that he had “passed on” This is every parents worst nightmare and let me tell you,what I heard next would have never crossed my mind.I thought maybe he was in an accident or somthing of course my son was a very careful driver but it doesn’t always have to be your fault.No,thats not what I heard,when I asked how they told me he had taken his own life.They had found him in his car with his hunting rifle between his legs at the tender age of 17.
All those years he was on a drug that appeared to be helping him…when all along it was eating at his mind.
frank at 10:54 pm on
April 9th, 2008
My daughter has been on singulair for the past six months.Since then she went from beign a happy 3yr old to having mood changes,crying for no reason,and having night terrors almost three times a week.After we read the article on the 28th of march we took her off the medication.Now she is back to being herself again.We immediately noticed the difference.I’m glad that we did.It’s so uncanny how everyones story sounds alike.
Bette at 8:01 am on
April 11th, 2008
I was put on Singulair Feb/March of 2006. I became depressed and started having nightmares. By the summer of 2006 I was isolating myself from all of my friends, I was crying daily the nightmares were now closer to nightterrors, 4-5+ a night. Some nights they were so bad I would wake up screaming and crying and obviously I was getting less and less sleep. December of 2007 I slit my wrist. I was hospitilized, there is no mental health illness in my family, I had never attempted suicide before. I went into counseling and did everything in my power to get better. I still had daily suicidal thoughts. Then while on vacation in Florida, with the nightmares and thoughts still occuring, I read in the US News front page article on Singulair. I stopped taking it immediately. I have not had another nightmare, night terror or for that matter a dream. I have slep through the night for the first time in over 2 years, I have not had another suicidal thought and I can laugh again. Although I still have to deal with the fact that I slit my wrist, I have a very huge and ugly scar, my children and husband have to come to terms with this as they held my arm together until the ambulance arrived. Singulair needs to be pulled off the market and Merk needs to be held accountable.
Gisella at 12:59 pm on
April 11th, 2008
Tengo una bebe de 3 años y medio que toma Singulair desde los 2 años, ella siempre ha tenido un caracter fuerte pero ultimamente desde que cumplio los 3 esta mucha mas irritable, llora por todo, grita mucho, no se la puede reprender porque llora, a pesar de dormir 8 horas diarias siempre es dificil levantarla temprano para ir al jardin, no se si sea causado por el medicamento (ella no es asmatica, es alergica) pero en verdad este tema me preocupa muchisimo porque tengo 2 sobrinas que tambien lo toman. Ojala y el estudio se termine muy pronto y podamos estar tranquilos porque es un buen medicamento.
Gloria at 9:45 am on
April 17th, 2008
I have been taking Singulair since i was in the 5th or 6th grade( now a Sophmore in college) but it has always been the 5mg chewable child’s dosage, and never really had any sign of depression! I was a happy child engaged in school and extra curricular activities that loved going to school and learning! That is until my doctor bumped up my dosage this past year to the 10mg hard swollable pill! I started having anxiety attachs for no reason in the middle of the day! i would cry uncontrolablly for hours! I would over stress about school and work and friends and family and the littlest things would set me off! And even just recently i’ve been so depressed about school and relationships and work that i have thought of ending it all just to escape the pain and overload! please don’t take this caution lightly! Since i heard about these now studies i have stopped taking singulair and have been gradually been seing inprovements in my self confidence and behavior! This is real and yes not everyone may experience thses side afects but that doesn’t mean that they are not there!
Mary at 10:21 pm on
April 17th, 2008
My son was diagnosed with asthma at a young age (2 years old). We tried many medications and whatnot. He started singular at the age of 5 or 6. He is now 14. He is a great student, gets along very well with his younger sister, and is always upbeat. We haven’t noticed any depression or negativity. His dosage is 5 mg. So far, Singular has been great. We tried changing to something else, but his asthma symptoms increased. With this new information, we will be keeping an eye on him.
Thank goodness I’m not the only one.
My son is 10 and has had asthma since he was 2 years old. 2 years ago he was prescribed Singulair 5mg. It was amazing - he was off oral steriods and we no longer had visits to A&E.
However, I have noticed such a change in him. He has no confidence, sleep problems, anxiety and school phobia. He has gone down from the top of the class and often complains of headaches and dizziness. He seems to be often on the verge of tears and not as sociable as he once was.
I am stopping his Singulair medication today, I will post another comment if it makes a difference.
Rob at 8:20 pm on
April 22nd, 2008
Remember that you take Singular instead of Prednisone. If you take prednisone, you will swell up, have a moon-face, feel hungry all the time, have osteoporosis [it reduces Calcium uptake], and prednisone paranoia.
Instead, you idiots curse at a one-off reaction that Singular causes suicidal thoughts in 1 of several 100’s of patients. If a medicine makes you feel better, PUT UP WITH THE SIDE EFFECTS or GET OFF THE MEDS.
IDIOTS.
Rob.
Helen at 5:12 am on
April 23rd, 2008
Suicidal thoughts in 1 of several 100’s of patients? Not so. See www.medications.com for evidence of what Singulaire is doing to many children.
I believe Singulaire is like Prozac, affecting children in a completely different way to adults. Look at the postings of the 550+ people under Singulaire on www.medications.com, look at the comments compared to their ages - a pattern emerges:
3-7 year olds become very aggressive
7-27 year olds become depressed, anxiety separation
27+ wonderful drug cures asthma/allergies
ple, look at their ages and a pattern emerges.
When my son became anxious, suffered panic attacks, depression, it took us 5 months to realise it was the Singulaire - the doctor thought it post traumatic stress following the first severe asthma attacks. By this time my happy son had turned dark, terrified, consumed by sadness, had lost 5-months of schooling, was suicidal. He was just nine.
Its not a case of ‘put up’ or ‘get off’ - if only life was so simple Rob.
SurReal at 9:36 am on
April 23rd, 2008
]Elmo wrote, “He snorted and made a rude remark about people who want to find something to blame things on.]
As a mother, you must be so proud!
SurReal at 9:45 am on
April 23rd, 2008
[Rob srote, “If a medicine makes you feel better, PUT UP WITH THE SIDE EFFECTS or GET OFF THE MEDS. IDIOTS.”]
While you are clearly omniscient, others may actually need to read and learn about things. How does educating about possible side effects / sharing symptoms that many people are experiencing make anyone an “idiot”? How does one make an educated decision to continue/discontinue a medication without information? How on earth do you think we learned about the dangers of MANY drugs that have been taken off the market?
Isobel at 11:32 am on
April 23rd, 2008
Our son started taking Singulair when he was 2 for severe allergic rhinitis and mild asthema (in addition to Zyrtec, which didn’t control all of his symptoms). He is 5 now. For the last three years, he has been an increasingly violent, difficult, defiant, argumentative, volatile child who has intense mood swings; one minute he’s laughing uncontrollably, the next he’s weeping over nothing. His doctor and therapist recommended that we see a psychiatrist to have him evaluated for bipolar disorder. As an aside, bipolar disorder used to be completely unknown in children. Because he has such chronic sleep problems, the doctor also suggested we take him off Singulair to see if it improved his sleep issues. Within a week, he was sleeping much better and was a calmer, happier, gentler boy. He suddenly could take “no” for an answer without trying to kill me (really). We thought that we were just in an unusual, calm window that would shift either to mania or intense sadness or both, any minute. We also thought that he was benefiting from better sleep. We were enjoying the rare reprieve. Four days ago, his springtime allergies really flared up. We gave him Singulair the next morning and by noon, he was in a full blown manic episode. I had to strap him into his car seat at one point to keep him from hurting either me or himself. It was then that we realized that Singulair might be causing his “bipolar” disorder. Of course, we stopped the Singulair. It is two days later and he a new boy. An hour ago I Googled “Singulair bipolar children” and got a few hits. I am stunned to read how similar other families’ experiences have been to ours. My poor little boy! I’m sure that many of you can imagine what our life has been like for the last few years.
As for Rob and his snarky comments. It wasn’t at all obvious that Singulair was the cause of my son’s issues. At 2 years old when he started, he couldn’t tell us how it was making him feel. Over the years as his behavioral and emotional problems emerged and intensified, we never linked it to this drug, nor did his doctors or therapists. I don’t know why you would have so much contempt for the folks posting here.
Sandy at 6:08 pm on
April 27th, 2008
I am so glad I check this site out. It really explanins a lot. I have a 13 year old down syndrome daughter who has sinus and allergey problems. things were getting worse so the doctor bumped up her 5mg too 10 mgs of the chewables. Since she can explain things in her own words she acts out and she has started pulling hair every day not wanting to go to school and puking every day. Along with telling me she has an ear ache and headache I just assumed it was her sinus causing it all. I have been searching for a Behavior therapists to go to school to help out as things are getting that bad. But after reading this I feel so much better. I am taking her off this and will find something else. She is always going to be prone to upper resportory infections but she is haveing more and more. I feel so relived!!!!!
Kristina at 10:29 am on
April 28th, 2008
I would def. send e/o over to medications.com There are hundreds of kids going through ADHD & Bipolar symptoms b/c of Singulair Including My 11 yr old son
I would like to know how some ppl think it would be so easy to tell what S/E’s were from Singulair when their child is on 4 other meds at the same time?
My son is already dx’d with ADHD & poss. Bipolar I thought his symptoms were getting worse with age?? Now I know it was singulair we are almost 4 wks free of it & OMG What a difference!! we are even cutting back on his other meds!!!
Please report your S/E’s to the FDA!!!
this drug might be great for some but for many others It’s cauing ADHD/Depression/Bipolar type behaviors!!
Carrie at 12:11 pm on
April 30th, 2008
I am a busy mother and wife who was a completely healthy person, no major medical issues ever with some season allergies and a mild case of asthma because of season allergies. I took Singulair for only three weeks about a year and a half ago and my life has not been the same.
After going to six specialist, they all now want me to go to Mayo Clinic.
When taking Singulair my symptoms were horrible aching in my legs, feet and ankles and the bottom of my feet would severely itch.
I stopped taking Singulair, but the symptoms continued and gradually got worse.
Now I have a severe case of hives and angioedema. The docs keep changing the allergy medication because it will work for a month and then stop. My other symptoms are horrible body aches, headaches/migraines, rage disorder (I have always been a very laid back person), anxiety, night terrors, blurred vision, positive ANA, thyroid antibodies are extremely elevated, consentration issues, and weight gain of 30 pounds (I was always very thin.
I have contacted the Merck Company. They were very nice to me, but have not done anything for me regarding the issues I am having. Basically they advised me to hire an attorney. I am more concerned about children being on this drug than hiring an attorney. Children are not able to communicate the way an adult can. I do not want to see anyone, especially a child suffer the way I am and have.
I understand not everyone will be effected in the same way, but Rob you need to be a little more caring and understanding. Maybe your attitude and remarks being so rude are due to the fact of you taking Singulair. I cannot imagine anyone having such a heartless reaction to other people, especially when you have no idea what others are experiencing.
Thank you for listening.
Kate Kendle at 2:59 pm on
May 1st, 2008
My son, A.J., was 17 and had been on Singulair on and off since he was 9 or 10. He started having psychiatric issues with depression and moodiness and TWO bouts with the chicken pox. He was taking it for asthma. The psychiatrist diagnosed him with severe depression but A.J. didn’t want to take meds because he was afraid that they would “change” him. I was ok with that. On October 2nd, 2007, the day that Merck made a “change” to their inserts, my son committed suicide. He was taking Singulair at the time. I don’t believe that Cody Miller’s suicide was an isolated case. It was most definitely an OBVIOUS case of Singulair related suicide as it was the only drug he was taking and had only been on it 17 days and had all the symptoms leading up to his suicide. How were we to know that a drug to help our kids breathe could affect their brains?
Rob, look in the mirror the next time you use the word “idiot”
Dani at 12:42 am on
May 4th, 2008
Hi! I’m a teen and I was taking Singulair for about a year. I was a happy joyful young girl until i started taking this drug. I had thoughts of suicide and often put a bunch of pills in my hand and verged on committing suicide. I also isolated myself from my friends and became some what of an outcast. I stopped taking Singulair and became happy and popular. I really believe that this drug is linked to suicidal thoughts and/or actions. I was a monster. I was irritable angry and I had horrible tantrums for no reason.
Sarah at 4:17 am on
May 8th, 2008
Hi, I am 16 and I have been on singulair for about a year at 3 month intervals. I was surprised to find out there is a link between singulair and suicide because singulair has changed my life before singulair I had to wear long sleeves in the middle of the summer and couldn’t sit on grass or even run and missed on average a month and a half of school a year. Now I can run and even play softball and grow plants and only missed to 4 days to allergies so singulair is a miracle drug.
GiGi at 6:57 am on
May 8th, 2008
My 10 year old son has been on Singulair for almost a year. 3 months ago he started pulling out his eyelashes and eyebrows, was saying he hated his life, calls himself a freak, says he is always sad and never happy. He’s been off this stuff for a week and a half and I believe we have seen moderate improvement in his behavior/attitude. The worst thing that hasn’t changed is the hair pulling, it really is affecting his life and the whole family. I am hoping this subsides soon.
Galen at 11:51 pm on
May 8th, 2008
i joke with my girlfriend calling singulair “my angry medicine,” she doesn’t think it’s very funny though. about a half hour after swallowing the pill, i am more angry and more irritated than ever for absolutely no reason. i’m typically a very calm easy going guy but this medicine makes makes my mood very mad, i just can’t control the anger i feel, i never feel or have every felt that way except when taking singulair. i have been taking it for about a year but only once or twice a week (when i get stuck being around animals) the asthma relief it offers is good but the psychological effects are horrible. i couldn’t imagine taking this medicine everyday. i’m sure it screwed a lot of people up for life. it must take a huge toll on body and mind.
patricia at 8:08 am on
May 9th, 2008
I have been on singuliar since 1999. My life has been turned upside down. I was angry for no reason all the time. Severly depressed, tremors, all of the side effects that that was mention on the fda’s webpage about the meds. I have suicidal thoughts but have not attemped it. I want more information on class action lawsuits. Right now, it is one firm that are looking for people who have down themselves bodly harm. But what about the other side effects. I think they are just as bad!!
Thanks for allowing me to share.
Michelle at 6:25 am on
May 22nd, 2008
My 6 year old was put on Singulair but I just pulled him off of it. He was having stomach problems at night after I gave it to him such as complaining of a stomach ache and very often vomiting. His sleep was very disturbed also. Last night I didn’t give him his Singulair and he slept like a baby. Within minutes he was out like a light. My son has also developed a very disturbing habit of eye rolling/twitching and I don’t know if it’s somehow related to the use of Singulair or not. I would not recommend this product to anyone although the doctors are so quick to push this onto people. Now I’m reading this medicine is a cause of behavoiral problems and can actually make users suicidal. No thanks! What the f.d.a. won’t approve. What a disappoinment the f.d.a. and what a disappontment this medicine turned out to be. I pray my son does not suffer any long term effects of this.
SassyT at 5:07 pm on
June 5th, 2008
I have two children, ages 13 & 15 who have been taking Singulair with great success for over 2 years now. When I (42 y/o female) developed out-of-control allergies earlier this year, my doctor prescribed me Singulair since nothing else on the market had helped.
After 7 weeks on this medication, I was instructed today to discontinue its use. Although it has helped my allergies considerably, I cannot begin to tell you my anxiety and depression symptoms have multiplied. I am currently on a mild anti-depressant as well as an “as needed” anxiety medicine. My first week on Singulair was noted with significant anxiety and panic attacks. They did subside as I began to get used to the medication. However, they never completely went away. Now they have become constant and strong, and the increased depression have triggered the m.d. to stop the meds for now to see if they subside.
I do not worry about my children on the meds, as I believe they would have had problems before now. Plus, I might be predispositioned for anxiety issues only to be increased by this med. Hopefully, I will know after discontinuing the use of this med for a couple of weeks if this was actually the cause.
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I have twin sons who have taken Singulair in the past, one of whom is currently taking it. Neither of them have ever had any of these symptoms. Singulair has worked wonders for both their allergy and asthma symptoms without side effects such as agitation, anger, or sleep disturbances.
Anyone can have a bad reaction to any drug. It’s a shame that an adverse reaction in such a tiny fraction of the number of people who take it can give a medication that works so well for so many a bad name.
My son has been taking singulair for asthma since he was 3. He is my only boy and I really can not say for sure if his behavior is related to the drug or not. He does seem to get very angry at times (compared to the way my daughter might react) but he surely needs to take something to keep his asthma under control and the other drugs also have reports of side effects. I called the doctor’s office today to see if he should stop taking the drug and they said he should continue. It is a hard decision because I need him to stay healthy. He is 9 now and I do think his behavior at times is hard to control. I (again) can not be sure it is related to the drug but it certainly is soemthing to think about. I hope they complete their investigation sooner than 9 months.
My son is 19 and has had respiratory problems almost all his life. When he was 5 he was diagnosed with asthma. Thanks to the American Lung Association, we were able to start the process of learning about asthma and the management of asthma. We learned about triggers and how to avoid them. We learned about subclinical symptoms and how to recognize them in advance of a full blown asthma attack. One of the subclinical symptoms in our son was irritability — some people would have called it anger but I don’t think that it ever rose to that level.
He started taking Singulair several years ago — not to deal with asthma but with an underlying allergic rhinitis which results in inflamed sinuses which have always been one of his triggers. It makes a huge difference. Aside from normal teenage angst, I don’t think he has had any suicidal tendencies. I pointed out the news article to him so that he would be aware of the possible potential. He snorted and made a rude remark about people who want to find something to blame things on.
My son started taking Singulair two years ago. The changes I have noticed in him are disturbing. He was always a gentle, smart boy who loved music. He was quick to laugh and had many friends. This past year he began to isolate himself. He no longer wanted play dates and would frequently cry for no reason. He developed insomnia and on the weekends was hard to rouse and sometimes slept as late as one PM. He talked about how he wanted to be alone and said he wanted to live on the street, away from his family. I could go on and on about the inexplicable, negative changes in my son. I told myself maybe it was just adolescence come early. He seemed so miserable and would no longer play with his younger brother when just a year or more ago they were inseparable. The most shocking thing is a few days ago I found a poem he had written, talking about how the world was a horrible place and it might be better if he died and flew away. You can imagine how heartbreaking it is to read something like this from a once happy, adored 10 year old. Just a day later I heard the news about Singulair causing suicidal thoughts. I immediately pulled him off the medication and the improvement in his mood already is enormous. I am fighting mad! Who would think an allergy medication would make a child’s world black and full of despair? It makes me sick to remember how every night I would remind him to take his Singulair thinking I was protecting him. Are there other children out there who have developed mood disorders and are taking this poison? I want to join a class action lawsuit. What can parents do to stop things like this happening again?
Hi, I am 47 yo and have had serious asthma for about 10 years now, after moving to the houston, texas, area obviously, my respiratory conditions worsened. I also suffer from depression and am on Effexor XR, which up until the last two months and starting again two days ago I believe is the best anti depressant on the market (for myself anyway). My Dr. prescribed Singulair May of 07 and I took it for several months, my older sister told me she had stopped taking it because she thought it had made her worse and I certainly wasn’t getting any better, so I stopped also. However, I came down with Pneumonia in September and blood work showed I was unable to fight my allergies, back on Singulair I went. I couldn’t seem to get back to myself, but I assumed it was from being ill for 2 months and off work. (I haven’t been to work on time since December of 07, no matter how much sleep I get, it is never enough.) However, the last two months and especially the last 2 weeks, anything negative has made me think of dying. All of my asthma meds have ruined my teeth & on Monday my dentist told me I would have to have dentures, when I left, the office staff was afraid I was going to kill myself. I went to Walmart this last Wednesday and when I was walking to my car I was short winded and tired and thought: “I’m 47, my teeth are gone, my lungs are shot, what’s the point in living?” I truly wanted to give up. This was a truly, profound thought. I believe Paul Harvey saved my life. The next morning (Thursday, 3/27/08) I heard the relation between Singulair and suicide, I stopped taking it immediately. It’s only been 2 days, but it gives me hope that my mind will improve, that I can focus and think clearly, that I will be successful at the job I have been at for 14 years again, that I can have a clean home again, enjoy life again, stop thinking about dying and start wanting to live. Sorry if I rambled, I just want to know how to get in touch with Merck or the FDA to tell them all of this.
I have been diagnosed with asthma since I was 14 years old, I am now 30. I have been on Singulair for just about 2 years and it has been 2 years of complete hell. My husband, bless his heart, has stuck through what we throught were hormonal instances (yeah, for 2 years???). I have been on different birth control thinking that was the issue, I have had rage fits, paranoid feelings, anxiety attacks, depression, fits of crying uncontrollably. Mind you, I have NEVER been this way in my life, besides the little up and down you get from your monthly cycle. Life has been horrible for 2 years, not because of me, my husband, or my step daughter, but because of this medicine. My husband told me about this on Friday and I literally wanted to break down in tears, finally…an answer to the craziness that was never in my life before! Even planning my wedding was affected by this nasty pill. I went off of this medicine immediately at the discresion of my doctor and I will never go on it again. I do have a hard time breathing and I was put on zyrtec instead of claritin-d (blood pressure issues), and I hope I’ll be able to find relief for my breathing in the near future. Until then, my inhaler will work just fine. BEWARE OF THIS DRUG!!!! Especially if you have a tendency to be more sensitive to medications than others. This can happen! There are too many people that have had this happen to them, I feel the FDA should NEVER put anything on the market to be given as medications without doing their complete homework and research on the drug first.
My nephew takes singulair and I strongly agree that his behavior has changed. He is a straight “A” student, and for the last 4 months he has had severe behavior problems. which has never happened before. I was so concerned that I have him seeing a psych doctor. It never occurred to me that it could be has medicine. He is happy one minute and in a rage the next minute. the teacher had sent a note home that he had started cutting hisself with his scissors( just like paper cuts) and she had to take his scissors away daily. I need more information on this. He has serious alleries and asthma. It hard to control his asthma, but he is going to stop taking it. I not willing to risk it.
My 10 year old daughter has been on singulair for two years. It has been wonderful not having the asthma attacks that used to hospitalize her for a week at a time. Yet, also for the last two years family members and myself have been trying to figure out why she gets so depressed so often. It is truly scary to find out that something you depended on to help your child may be what is hurting them. There are other medications out there to help control asthma, my childs mental health is just as important as here ability to breath. I have taken her off of Singular and am in contact with her doctor to find another option for her asthma. I want a happy and healthy child that can breath. It does’nt matter if a child has asthma when their dead. I understand alot of people have and are taking this medication. My question is will my child tell me her feelings before its to late. I’m not willing to take that risk, are you? Please listen to these warnings if you have a child on singular.
I’m in my late 30’s and I have taken Singulair and Zyrtec for 3 years. I have not had any thoughts of suicide or depression. I even took Singulair during pregnancy and didn’t have any suicidal thoughts, depression, or emotional outbursts. I have anxiety, but have found that Singulair doesn’t make it any worse. I’m a small person and very sensitive to most medications so I’m surprised to see this type of labeling. I think research should be done before we start condemning it.
I started taking Singulair a year ago. During the past year my depression definitely got worse. This is anecdotal, I realize, but I am not going to take Singulair any more. The SI became too strong for me to take this lightly. My pharmacist thinks that I am making too much of this story. Too bad. To err on the side of caution beats possibly losing my life to my disease.
I was just recently diagnoised as having ashtma. My doctor started me on singulair. I also treat depression and anxiety and have been treating with Paxil and have been doing fine for several years.
I will say that in the short time I have been taking the singulair, I have had a lot of anger, lacked control in some instances and had a hard time of letting go of the angers. I also began to isolate myself from others. Upon discussing this with my doctor, he pulled me off the drug.
My 6 year old daughter has been on Singulair for about two years. In the past several months she had been getting more and more angry and irritable. If the slightest thing would not go the way she thought it sould, she would yell and stomp around and be in a horrible mood for hours. My 5 year old son refused to play with her because he said “she is too mean and will just yell at me.” We tried to find problems in school or with friends, but couldn’t find a source of her anger, frustration, and irritability. We were ready to have her start seeing a physiatrist for anxiety and depression. The problem we were struggling with is that she didn’t seem to have all the symptoms that are identified with children suffering from depression. We searched many sources regarding children and mood disorders and nothing seemed to fit.
By coincidence, we didn’t get her Singuliar prescription refilled for about a week and a half. We kept forgetting to call it in and then a few more days passed before we picked it up. Without making the connection, we noticed that she started having really good days. She wasn’t yelling, she didn’t argue and cry like she had been, and she seemed happy for a change.
The day after we started her back on the Singulair, I read the article about the FDA questioning Merck regarding Singulair. My heart skipped a beat. I e-mailed it to my wife who quickly found an online forum from parents relating eerily similar stories about their child’s behavior while taking Singulair. We have not given it to her since and we now have our happy little girl back. We’re working with her pulmonolgist to come up with an alternative, but will not giver her Singulair again.
I’m sure Singulair has worked very well for many people. But, if you or your child are taking Singulair and are having mood or behavior problems, then please talk to your doctor and look at the possibility that Singulair is the cause.
I have a 10 year old son that has been on Singulair now for 6 years…he was always a loving and caring child. He and his sister have always been very close and loving toeach other…he was like a little daddy with her, you couldn’t ask for a better big brother!! He always made good grades in school and loved school, until this past year!!! He has made a complete 360! He started haveing school phobia is what the doctors called it along with anxiety and depression…crying all the time over anything. I took him to the doctor and they dignosed him with ADHD and put him on aderal…I cried because, I never wanted to believe he needed such a drug. The Aderale has not helped anything if anything it has only made it worse. He is even more irritable than he was. I think doctors are putting children on ADHD medicine was too easily…like it solves all the problems. I am suprised to hear this about Singulair!!! It makes me very angry to think that I thought I was giving my son something that would help him to know that is is only causing him to suffer greatly!!! I have been so worried and confused about what is happening to my loving and caring son!!!! I deffinately want to join the class action law suit!!!!!!!!!!!!!!!!!!!!!!!
Just recently my daughter who is 5 has started mood changes and isolating herself more at home. I am in utter shock about the news from Merck. She started Singulair about 4 months ago because of 1 excercise induced asthma attack. She’s a loving child but recently she yells/screams at her younger brother over nothing and is decreasing her desire to do Karate which she loved dearly. Mood swings in children can be contributed to other things but when my wife mentioned about a report linking depression to Singulair I started doing my research. I read the FDA report and Merck’s response today telling me I have to wait 9 months for further studies. I am a heathcare professional and spoke to one of our Pulmonologists today but he could not offer anymore insight then what is published already but he is not taking his patients off Singulair. I am torn over what to do. I sincerly appreiate everyones comments on the website and I am surprised reading how similar my daughter sounds to your children.
My 5 year old son was diagnosed with mild asthma and put on Singulair. Within a few months he began having uncontrollable fits of rage, displayed self-loathing behavior, had night terrors, and was inconsolable during these episodes. He became very destructive and was a danger to himself and our family. He even talked about killing himself and would say things like “I don’t want to be in this life anymore” and “I want to kill myself”. He would threaten my wife and his siblings and told them he wanted to kill them. It was a truly terrifying experience. Our pediatrician was clueless to these side affects and recommended we have our child go through a psychological evaluation. I knew this was not my child’s normal behavior so I searched the internet for Singulair side effects and found some message boards where parents just like me were writing about severe changes in their children’s behavior. I immediately took my son off the drug and within a couple weeks he was back to his normal self. He told us that he no longer has “that feeling inside of him”. Five year old children don’t even know what suicide is and to see my son talk like this was extremely frightening as you can imagine. He is a sweet, intelligent, loving boy who had never exhibited behavior like this until he went on Singulair. We have not seen this behavior after taking him off the drug and he has NEVER taken any other drug so it’s impossible to create that correlation with other preexisting issues. If we had listened to our pediatrician our son may have been misdiagnosed with ADHD or the like and further ruined by Ritalin or some other zombifying drug. I don’t know about you but it’s my belief that the pharmaceutical industry and practitioners in our country have already successfully created a “Prozac Nation” as I like to call it. This is dead wrong on every level.
If you go to http://www.medications.com/se/singulair you can read some of these experiences. You won’t believe what’s going on. There are over 30 pages of personal experiences on the site.
I’ve personally communicated with a leading professor of Pharmacology and Pediatrics at the University of Florida who I quote as saying “In response to your last comment, I thing Singulair has modest efficacy, and if we take all of our patients off this drug, they won’t suffer. This is not an important drug for pediatric asthma, as are inhaled corticosteroids.” Yet Singulair is the most overprescribed drug on the market today!!!!!!!!!
My 8 year old son has been on singulair since he was 4. He has been much more aggressive than his older brother, with many meltdowns. At age 8, he is now depressed, suicidal, aggressive, etc. He states “I can’t control myself.” I immediately pulled him off of the singulair after the news report and he is already much happier. We haven’t had any meltdowns or crying since he came off.
I started taking Singulair in September 2007. The drug worked well to keep my asthma and allergies under control. I noticed in October 2007 that I started feeling depressed and didn’t want to do anything. I thought these feelings were related to the fact that the school district I work for was out on strike. Once I started back to work in November the feeling didn’t subside, in fact, it became worse. In December I started having feelings of anxiety. I thought the anxiety was related to some issues my husband and I were having. In January everything calmed down except for me. I started flying off the handle, accusing my husband and friends of doing things they weren’t. I had a hard time cleaning my house, dealing with my kids, and keeping up at work. Throughout February and March I got worse and worse. To the point I thought my husband and I would split up. Last week I started having serious suicidal thoughts. At this point my friend called and told me to quit taking Singulair because she heard about the suicide and behavior changes associated with this drug. I stopped taking the drug 3 days ago and I finally feel like myself after 7 months. Hopefully as this drug gets out of my system I will be my happy go lucky self again.
I found out about all this in the last couple days. I have a 12 year old son who has had many of the same behaviors listed by other parents here. His grades went from all B’s to D’s and F’s, he is violent and mean to his brother, and is very detatched from me when we were always very close. I had everyone telling me it was becuase he just turned 12, but his behavior had become scarry to me with his lack of caring for anything. We are stopping the singulair as of tonight, and we’ll see if there are any changes. If not we’ll just know he is being a pre-teen. But if he goes back to who he was a year ago, then I will be very verbal about the dangers of this drug!
Our 10 year old daughter has had Asthma since she was 2 and we have tried a good deal of medications to control her condition, including Singulair. Singulair. Singular seemed to help with the asthma but it took us over a year to realize that it also caused dramatic agitation with her during bed time (about an hour after taking the meds). My husband and I thought it was defiance on her part. We elimated so many things from her diet trying to find the cause and finally figured tried the Singulair and once removed she imediately became a happy child again. Now we realize all drugs have side effects and they affect more than what is published! . Since then, were done with drugs and have significant improvement with holistic natural remedies.
What is the process for submitting complaints about side effects from a drug? when we told our doctor about the side effects they did not make a note in her file, they did not call the pharmacutical company…very interesting that there is not a system in place that we are aware???
I been on singular for almost two months,I noticed I can’t sleep actually affraid to sleep i have had this chronic cough for 10 months /w breathing problems I’m 44 and my health is going I been getting depressed becaused i been in the Emergency room 29 time since October of 2007,and not getting better, i get short winded just walking acrossed the parking lot,I don’t want to live like this,I get all kinds of bad thoughts, i wanted to leave my husband of 25 years, and accused him of cheating,i packed my house and got rid of my daughters cats.I do not like feeling like this Mean person.it seems like i feel angry mad and depressed,lost my appitite and can’t sleep.I call to make an appointment with my Doctor she recomended me to stop taking Singular.Now I need to try and save my marriage,and everyone i have been rude /mean /angry to. i hope this ugly person is gone. I don’t care for her.I want my life back too.
For those people that seem to be depressed on Singulair, try Zyflo cr. It is probably even more potent in severe asthma. It works differently than Singulair
CRITICAL THERAPEUTICS’ ZYFLO® RECEIVES DISTINCT CLASSIFICATION UNDER MEDICARE PRESCRIPTION DRUG BENEFIT Lexington, Mass., May 25, 2006 – Critical Therapeutics, Inc. (Nasdaq: CRTX) today announced that the Centers for Medicare and Medicaid Services (CMS) has created a unique Formulary Key Drug Type (FKDT) category for the Company’s asthma drug, ZYFLO® (zileuton tablets), under guidelines developed specifically for the Medicare Prescription Drug Benefit (Part D). This new category reflects the CMS’ adoption of the United States Pharmacopeias’ (USP) 2007 Model Guidelines. Under the new FKDT, ZYFLO is now categorized as a “Synthesis Inhibitor” based on its pharmacologic distinction from other anti-leukotriene compounds, including Merck’s Singulair®, which are grouped together in a category known as “Receptor Antagonists.” ZYFLO is the only 5-lipoxygenase (5-LO) inhibitor approved by U.S. Food and Drug Administration
My son started taking singulair at the age of 13 after claratin became an over the counter drug.Over the years he started to have sleeping problems and was dealing with depression on a regular basis.We went to the doctors for help and were prescribed drugs for depression which he said didn’t help.He started to isolate himself from family events,dropped out of high school and started sleeping a few hours during the day because he said he couldn’t sleep at night.
On the morning on January 4th of 2006 I was informed by the local police Dept when I reported my son missing that he had “passed on” This is every parents worst nightmare and let me tell you,what I heard next would have never crossed my mind.I thought maybe he was in an accident or somthing of course my son was a very careful driver but it doesn’t always have to be your fault.No,thats not what I heard,when I asked how they told me he had taken his own life.They had found him in his car with his hunting rifle between his legs at the tender age of 17.
All those years he was on a drug that appeared to be helping him…when all along it was eating at his mind.
My daughter has been on singulair for the past six months.Since then she went from beign a happy 3yr old to having mood changes,crying for no reason,and having night terrors almost three times a week.After we read the article on the 28th of march we took her off the medication.Now she is back to being herself again.We immediately noticed the difference.I’m glad that we did.It’s so uncanny how everyones story sounds alike.
I was put on Singulair Feb/March of 2006. I became depressed and started having nightmares. By the summer of 2006 I was isolating myself from all of my friends, I was crying daily the nightmares were now closer to nightterrors, 4-5+ a night. Some nights they were so bad I would wake up screaming and crying and obviously I was getting less and less sleep. December of 2007 I slit my wrist. I was hospitilized, there is no mental health illness in my family, I had never attempted suicide before. I went into counseling and did everything in my power to get better. I still had daily suicidal thoughts. Then while on vacation in Florida, with the nightmares and thoughts still occuring, I read in the US News front page article on Singulair. I stopped taking it immediately. I have not had another nightmare, night terror or for that matter a dream. I have slep through the night for the first time in over 2 years, I have not had another suicidal thought and I can laugh again. Although I still have to deal with the fact that I slit my wrist, I have a very huge and ugly scar, my children and husband have to come to terms with this as they held my arm together until the ambulance arrived. Singulair needs to be pulled off the market and Merk needs to be held accountable.
Tengo una bebe de 3 años y medio que toma Singulair desde los 2 años, ella siempre ha tenido un caracter fuerte pero ultimamente desde que cumplio los 3 esta mucha mas irritable, llora por todo, grita mucho, no se la puede reprender porque llora, a pesar de dormir 8 horas diarias siempre es dificil levantarla temprano para ir al jardin, no se si sea causado por el medicamento (ella no es asmatica, es alergica) pero en verdad este tema me preocupa muchisimo porque tengo 2 sobrinas que tambien lo toman. Ojala y el estudio se termine muy pronto y podamos estar tranquilos porque es un buen medicamento.
I have been taking Singulair since i was in the 5th or 6th grade( now a Sophmore in college) but it has always been the 5mg chewable child’s dosage, and never really had any sign of depression! I was a happy child engaged in school and extra curricular activities that loved going to school and learning! That is until my doctor bumped up my dosage this past year to the 10mg hard swollable pill! I started having anxiety attachs for no reason in the middle of the day! i would cry uncontrolablly for hours! I would over stress about school and work and friends and family and the littlest things would set me off! And even just recently i’ve been so depressed about school and relationships and work that i have thought of ending it all just to escape the pain and overload! please don’t take this caution lightly! Since i heard about these now studies i have stopped taking singulair and have been gradually been seing inprovements in my self confidence and behavior! This is real and yes not everyone may experience thses side afects but that doesn’t mean that they are not there!
My son was diagnosed with asthma at a young age (2 years old). We tried many medications and whatnot. He started singular at the age of 5 or 6. He is now 14. He is a great student, gets along very well with his younger sister, and is always upbeat. We haven’t noticed any depression or negativity. His dosage is 5 mg. So far, Singular has been great. We tried changing to something else, but his asthma symptoms increased. With this new information, we will be keeping an eye on him.
Thank goodness I’m not the only one.
My son is 10 and has had asthma since he was 2 years old. 2 years ago he was prescribed Singulair 5mg. It was amazing - he was off oral steriods and we no longer had visits to A&E.
However, I have noticed such a change in him. He has no confidence, sleep problems, anxiety and school phobia. He has gone down from the top of the class and often complains of headaches and dizziness. He seems to be often on the verge of tears and not as sociable as he once was.
I am stopping his Singulair medication today, I will post another comment if it makes a difference.
Remember that you take Singular instead of Prednisone. If you take prednisone, you will swell up, have a moon-face, feel hungry all the time, have osteoporosis [it reduces Calcium uptake], and prednisone paranoia.
Instead, you idiots curse at a one-off reaction that Singular causes suicidal thoughts in 1 of several 100’s of patients. If a medicine makes you feel better, PUT UP WITH THE SIDE EFFECTS or GET OFF THE MEDS.
IDIOTS.
Rob.
Suicidal thoughts in 1 of several 100’s of patients? Not so. See www.medications.com for evidence of what Singulaire is doing to many children.
I believe Singulaire is like Prozac, affecting children in a completely different way to adults. Look at the postings of the 550+ people under Singulaire on www.medications.com, look at the comments compared to their ages - a pattern emerges:
3-7 year olds become very aggressive
7-27 year olds become depressed, anxiety separation
27+ wonderful drug cures asthma/allergies
ple, look at their ages and a pattern emerges.
When my son became anxious, suffered panic attacks, depression, it took us 5 months to realise it was the Singulaire - the doctor thought it post traumatic stress following the first severe asthma attacks. By this time my happy son had turned dark, terrified, consumed by sadness, had lost 5-months of schooling, was suicidal. He was just nine.
Its not a case of ‘put up’ or ‘get off’ - if only life was so simple Rob.
]Elmo wrote, “He snorted and made a rude remark about people who want to find something to blame things on.]
As a mother, you must be so proud!
[Rob srote, “If a medicine makes you feel better, PUT UP WITH THE SIDE EFFECTS or GET OFF THE MEDS. IDIOTS.”]
While you are clearly omniscient, others may actually need to read and learn about things. How does educating about possible side effects / sharing symptoms that many people are experiencing make anyone an “idiot”? How does one make an educated decision to continue/discontinue a medication without information? How on earth do you think we learned about the dangers of MANY drugs that have been taken off the market?
Our son started taking Singulair when he was 2 for severe allergic rhinitis and mild asthema (in addition to Zyrtec, which didn’t control all of his symptoms). He is 5 now. For the last three years, he has been an increasingly violent, difficult, defiant, argumentative, volatile child who has intense mood swings; one minute he’s laughing uncontrollably, the next he’s weeping over nothing. His doctor and therapist recommended that we see a psychiatrist to have him evaluated for bipolar disorder. As an aside, bipolar disorder used to be completely unknown in children. Because he has such chronic sleep problems, the doctor also suggested we take him off Singulair to see if it improved his sleep issues. Within a week, he was sleeping much better and was a calmer, happier, gentler boy. He suddenly could take “no” for an answer without trying to kill me (really). We thought that we were just in an unusual, calm window that would shift either to mania or intense sadness or both, any minute. We also thought that he was benefiting from better sleep. We were enjoying the rare reprieve. Four days ago, his springtime allergies really flared up. We gave him Singulair the next morning and by noon, he was in a full blown manic episode. I had to strap him into his car seat at one point to keep him from hurting either me or himself. It was then that we realized that Singulair might be causing his “bipolar” disorder. Of course, we stopped the Singulair. It is two days later and he a new boy. An hour ago I Googled “Singulair bipolar children” and got a few hits. I am stunned to read how similar other families’ experiences have been to ours. My poor little boy! I’m sure that many of you can imagine what our life has been like for the last few years.
As for Rob and his snarky comments. It wasn’t at all obvious that Singulair was the cause of my son’s issues. At 2 years old when he started, he couldn’t tell us how it was making him feel. Over the years as his behavioral and emotional problems emerged and intensified, we never linked it to this drug, nor did his doctors or therapists. I don’t know why you would have so much contempt for the folks posting here.
I am so glad I check this site out. It really explanins a lot. I have a 13 year old down syndrome daughter who has sinus and allergey problems. things were getting worse so the doctor bumped up her 5mg too 10 mgs of the chewables. Since she can explain things in her own words she acts out and she has started pulling hair every day not wanting to go to school and puking every day. Along with telling me she has an ear ache and headache I just assumed it was her sinus causing it all. I have been searching for a Behavior therapists to go to school to help out as things are getting that bad. But after reading this I feel so much better. I am taking her off this and will find something else. She is always going to be prone to upper resportory infections but she is haveing more and more. I feel so relived!!!!!
I would def. send e/o over to medications.com There are hundreds of kids going through ADHD & Bipolar symptoms b/c of Singulair Including My 11 yr old son
I would like to know how some ppl think it would be so easy to tell what S/E’s were from Singulair when their child is on 4 other meds at the same time?
My son is already dx’d with ADHD & poss. Bipolar I thought his symptoms were getting worse with age?? Now I know it was singulair we are almost 4 wks free of it & OMG What a difference!! we are even cutting back on his other meds!!!
Please report your S/E’s to the FDA!!!
this drug might be great for some but for many others It’s cauing ADHD/Depression/Bipolar type behaviors!!
I am a busy mother and wife who was a completely healthy person, no major medical issues ever with some season allergies and a mild case of asthma because of season allergies. I took Singulair for only three weeks about a year and a half ago and my life has not been the same.
After going to six specialist, they all now want me to go to Mayo Clinic.
When taking Singulair my symptoms were horrible aching in my legs, feet and ankles and the bottom of my feet would severely itch.
I stopped taking Singulair, but the symptoms continued and gradually got worse.
Now I have a severe case of hives and angioedema. The docs keep changing the allergy medication because it will work for a month and then stop. My other symptoms are horrible body aches, headaches/migraines, rage disorder (I have always been a very laid back person), anxiety, night terrors, blurred vision, positive ANA, thyroid antibodies are extremely elevated, consentration issues, and weight gain of 30 pounds (I was always very thin.
I have contacted the Merck Company. They were very nice to me, but have not done anything for me regarding the issues I am having. Basically they advised me to hire an attorney. I am more concerned about children being on this drug than hiring an attorney. Children are not able to communicate the way an adult can. I do not want to see anyone, especially a child suffer the way I am and have.
I understand not everyone will be effected in the same way, but Rob you need to be a little more caring and understanding. Maybe your attitude and remarks being so rude are due to the fact of you taking Singulair. I cannot imagine anyone having such a heartless reaction to other people, especially when you have no idea what others are experiencing.
Thank you for listening.
My son, A.J., was 17 and had been on Singulair on and off since he was 9 or 10. He started having psychiatric issues with depression and moodiness and TWO bouts with the chicken pox. He was taking it for asthma. The psychiatrist diagnosed him with severe depression but A.J. didn’t want to take meds because he was afraid that they would “change” him. I was ok with that. On October 2nd, 2007, the day that Merck made a “change” to their inserts, my son committed suicide. He was taking Singulair at the time. I don’t believe that Cody Miller’s suicide was an isolated case. It was most definitely an OBVIOUS case of Singulair related suicide as it was the only drug he was taking and had only been on it 17 days and had all the symptoms leading up to his suicide. How were we to know that a drug to help our kids breathe could affect their brains?
Rob, look in the mirror the next time you use the word “idiot”
Hi! I’m a teen and I was taking Singulair for about a year. I was a happy joyful young girl until i started taking this drug. I had thoughts of suicide and often put a bunch of pills in my hand and verged on committing suicide. I also isolated myself from my friends and became some what of an outcast. I stopped taking Singulair and became happy and popular. I really believe that this drug is linked to suicidal thoughts and/or actions. I was a monster. I was irritable angry and I had horrible tantrums for no reason.
Hi, I am 16 and I have been on singulair for about a year at 3 month intervals. I was surprised to find out there is a link between singulair and suicide because singulair has changed my life before singulair I had to wear long sleeves in the middle of the summer and couldn’t sit on grass or even run and missed on average a month and a half of school a year. Now I can run and even play softball and grow plants and only missed to 4 days to allergies so singulair is a miracle drug.
My 10 year old son has been on Singulair for almost a year. 3 months ago he started pulling out his eyelashes and eyebrows, was saying he hated his life, calls himself a freak, says he is always sad and never happy. He’s been off this stuff for a week and a half and I believe we have seen moderate improvement in his behavior/attitude. The worst thing that hasn’t changed is the hair pulling, it really is affecting his life and the whole family. I am hoping this subsides soon.
i joke with my girlfriend calling singulair “my angry medicine,” she doesn’t think it’s very funny though. about a half hour after swallowing the pill, i am more angry and more irritated than ever for absolutely no reason. i’m typically a very calm easy going guy but this medicine makes makes my mood very mad, i just can’t control the anger i feel, i never feel or have every felt that way except when taking singulair. i have been taking it for about a year but only once or twice a week (when i get stuck being around animals) the asthma relief it offers is good but the psychological effects are horrible. i couldn’t imagine taking this medicine everyday. i’m sure it screwed a lot of people up for life. it must take a huge toll on body and mind.
I have been on singuliar since 1999. My life has been turned upside down. I was angry for no reason all the time. Severly depressed, tremors, all of the side effects that that was mention on the fda’s webpage about the meds. I have suicidal thoughts but have not attemped it. I want more information on class action lawsuits. Right now, it is one firm that are looking for people who have down themselves bodly harm. But what about the other side effects. I think they are just as bad!!
Thanks for allowing me to share.
My 6 year old was put on Singulair but I just pulled him off of it. He was having stomach problems at night after I gave it to him such as complaining of a stomach ache and very often vomiting. His sleep was very disturbed also. Last night I didn’t give him his Singulair and he slept like a baby. Within minutes he was out like a light. My son has also developed a very disturbing habit of eye rolling/twitching and I don’t know if it’s somehow related to the use of Singulair or not. I would not recommend this product to anyone although the doctors are so quick to push this onto people. Now I’m reading this medicine is a cause of behavoiral problems and can actually make users suicidal. No thanks! What the f.d.a. won’t approve. What a disappoinment the f.d.a. and what a disappontment this medicine turned out to be. I pray my son does not suffer any long term effects of this.
I have two children, ages 13 & 15 who have been taking Singulair with great success for over 2 years now. When I (42 y/o female) developed out-of-control allergies earlier this year, my doctor prescribed me Singulair since nothing else on the market had helped.
After 7 weeks on this medication, I was instructed today to discontinue its use. Although it has helped my allergies considerably, I cannot begin to tell you my anxiety and depression symptoms have multiplied. I am currently on a mild anti-depressant as well as an “as needed” anxiety medicine. My first week on Singulair was noted with significant anxiety and panic attacks. They did subside as I began to get used to the medication. However, they never completely went away. Now they have become constant and strong, and the increased depression have triggered the m.d. to stop the meds for now to see if they subside.
I do not worry about my children on the meds, as I believe they would have had problems before now. Plus, I might be predispositioned for anxiety issues only to be increased by this med. Hopefully, I will know after discontinuing the use of this med for a couple of weeks if this was actually the cause.



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