World of Psychology

Asthma + Singulair = Suicide?

By John M Grohol PsyD
March 27, 2008

No, not yet.

But the U.S. Food and Drug Administration (FDA) today notified the maker of Singulair, a popular drug used to treat asthma, that it wanted more information and data about its use and suicide and suicidal thoughts.

According to a report at WebMD, “In response to inquiries received by the FDA, the FDA has asked Merck to evaluate Singulair study data for more information about suicidality and suicide. The FDA is also reviewing its postmarketing reports of behavior/mood changes, suicidality, and suicide in patients who took Singulair.”

The FDA said it is also reviewing reports of behavioral changes in patients taking similar drugs, including AstraZeneca Plc’s Accolate and Critical Therapeutics Inc’s Zyflo, but has not yet decided whether further investigation is needed.

All three drugs are known as leukotriene agents that work by controlling leukotrienes — chemicals in the body that are released during an allergic reaction and can lead to inflammation, congestion and other symptoms.

In a statement, Merck said its analysis of more than 11,000 patients in 40 clinical trials of Singulair found no reported suicides or suicidal thoughts or behavior.

The FDA suggested no one should go off of their medication before first talking to their doctor. Doctors should more closely monitor patients on one of these drugs for changes in mood or behavior, especially related to suicidal thoughts (especially in people who have no prior history of having any).

You can read more about the issue from this Reuters report on the FDA’s request about Singulair and suicide.

Updates:

On April 23 2008, the FDA approved changes Merck made to the package insert that mentions agitation, depression, irritability and “suicidal thinking and behavior (including suicide).” The information is also on a Singulair website, but some pharmacists still dispense from older shipments delivered before the label changes.

On May 3 2008, The (Albany) Times Union published this account that stated:

FDA officials will collect personal stories of people experiencing unusual side effects while taking the allergy drug Singulair, a move that follows a meeting Friday with a Queensbury couple who blame the medication for prompting their son’s suicide.


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Bad medicine « The Sin City Siren (4/8/2008)

81 Comments to
“Asthma + Singulair = Suicide?”

I have twin sons who have taken Singulair in the past, one of whom is currently taking it. Neither of them have ever had any of these symptoms. Singulair has worked wonders for both their allergy and asthma symptoms without side effects such as agitation, anger, or sleep disturbances.

Anyone can have a bad reaction to any drug. It’s a shame that an adverse reaction in such a tiny fraction of the number of people who take it can give a medication that works so well for so many a bad name.

My son has been taking singulair for asthma since he was 3. He is my only boy and I really can not say for sure if his behavior is related to the drug or not. He does seem to get very angry at times (compared to the way my daughter might react) but he surely needs to take something to keep his asthma under control and the other drugs also have reports of side effects. I called the doctor’s office today to see if he should stop taking the drug and they said he should continue. It is a hard decision because I need him to stay healthy. He is 9 now and I do think his behavior at times is hard to control. I (again) can not be sure it is related to the drug but it certainly is soemthing to think about. I hope they complete their investigation sooner than 9 months.

My son is 19 and has had respiratory problems almost all his life. When he was 5 he was diagnosed with asthma. Thanks to the American Lung Association, we were able to start the process of learning about asthma and the management of asthma. We learned about triggers and how to avoid them. We learned about subclinical symptoms and how to recognize them in advance of a full blown asthma attack. One of the subclinical symptoms in our son was irritability — some people would have called it anger but I don’t think that it ever rose to that level.

He started taking Singulair several years ago — not to deal with asthma but with an underlying allergic rhinitis which results in inflamed sinuses which have always been one of his triggers. It makes a huge difference. Aside from normal teenage angst, I don’t think he has had any suicidal tendencies. I pointed out the news article to him so that he would be aware of the possible potential. He snorted and made a rude remark about people who want to find something to blame things on.

My son started taking Singulair two years ago. The changes I have noticed in him are disturbing. He was always a gentle, smart boy who loved music. He was quick to laugh and had many friends. This past year he began to isolate himself. He no longer wanted play dates and would frequently cry for no reason. He developed insomnia and on the weekends was hard to rouse and sometimes slept as late as one PM. He talked about how he wanted to be alone and said he wanted to live on the street, away from his family. I could go on and on about the inexplicable, negative changes in my son. I told myself maybe it was just adolescence come early. He seemed so miserable and would no longer play with his younger brother when just a year or more ago they were inseparable. The most shocking thing is a few days ago I found a poem he had written, talking about how the world was a horrible place and it might be better if he died and flew away. You can imagine how heartbreaking it is to read something like this from a once happy, adored 10 year old. Just a day later I heard the news about Singulair causing suicidal thoughts. I immediately pulled him off the medication and the improvement in his mood already is enormous. I am fighting mad! Who would think an allergy medication would make a child’s world black and full of despair? It makes me sick to remember how every night I would remind him to take his Singulair thinking I was protecting him. Are there other children out there who have developed mood disorders and are taking this poison? I want to join a class action lawsuit. What can parents do to stop things like this happening again?

Hi, I am 47 yo and have had serious asthma for about 10 years now, after moving to the houston, texas, area obviously, my respiratory conditions worsened. I also suffer from depression and am on Effexor XR, which up until the last two months and starting again two days ago I believe is the best anti depressant on the market (for myself anyway). My Dr. prescribed Singulair May of 07 and I took it for several months, my older sister told me she had stopped taking it because she thought it had made her worse and I certainly wasn’t getting any better, so I stopped also. However, I came down with Pneumonia in September and blood work showed I was unable to fight my allergies, back on Singulair I went. I couldn’t seem to get back to myself, but I assumed it was from being ill for 2 months and off work. (I haven’t been to work on time since December of 07, no matter how much sleep I get, it is never enough.) However, the last two months and especially the last 2 weeks, anything negative has made me think of dying. All of my asthma meds have ruined my teeth & on Monday my dentist told me I would have to have dentures, when I left, the office staff was afraid I was going to kill myself. I went to Walmart this last Wednesday and when I was walking to my car I was short winded and tired and thought: “I’m 47, my teeth are gone, my lungs are shot, what’s the point in living?” I truly wanted to give up. This was a truly, profound thought. I believe Paul Harvey saved my life. The next morning (Thursday, 3/27/08) I heard the relation between Singulair and suicide, I stopped taking it immediately. It’s only been 2 days, but it gives me hope that my mind will improve, that I can focus and think clearly, that I will be successful at the job I have been at for 14 years again, that I can have a clean home again, enjoy life again, stop thinking about dying and start wanting to live. Sorry if I rambled, I just want to know how to get in touch with Merck or the FDA to tell them all of this.

I have been diagnosed with asthma since I was 14 years old, I am now 30. I have been on Singulair for just about 2 years and it has been 2 years of complete hell. My husband, bless his heart, has stuck through what we throught were hormonal instances (yeah, for 2 years???). I have been on different birth control thinking that was the issue, I have had rage fits, paranoid feelings, anxiety attacks, depression, fits of crying uncontrollably. Mind you, I have NEVER been this way in my life, besides the little up and down you get from your monthly cycle. Life has been horrible for 2 years, not because of me, my husband, or my step daughter, but because of this medicine. My husband told me about this on Friday and I literally wanted to break down in tears, finally…an answer to the craziness that was never in my life before! Even planning my wedding was affected by this nasty pill. I went off of this medicine immediately at the discresion of my doctor and I will never go on it again. I do have a hard time breathing and I was put on zyrtec instead of claritin-d (blood pressure issues), and I hope I’ll be able to find relief for my breathing in the near future. Until then, my inhaler will work just fine. BEWARE OF THIS DRUG!!!! Especially if you have a tendency to be more sensitive to medications than others. This can happen! There are too many people that have had this happen to them, I feel the FDA should NEVER put anything on the market to be given as medications without doing their complete homework and research on the drug first.

My nephew takes singulair and I strongly agree that his behavior has changed. He is a straight “A” student, and for the last 4 months he has had severe behavior problems. which has never happened before. I was so concerned that I have him seeing a psych doctor. It never occurred to me that it could be has medicine. He is happy one minute and in a rage the next minute. the teacher had sent a note home that he had started cutting hisself with his scissors( just like paper cuts) and she had to take his scissors away daily. I need more information on this. He has serious alleries and asthma. It hard to control his asthma, but he is going to stop taking it. I not willing to risk it.

My 10 year old daughter has been on singulair for two years. It has been wonderful not having the asthma attacks that used to hospitalize her for a week at a time. Yet, also for the last two years family members and myself have been trying to figure out why she gets so depressed so often. It is truly scary to find out that something you depended on to help your child may be what is hurting them. There are other medications out there to help control asthma, my childs mental health is just as important as here ability to breath. I have taken her off of Singular and am in contact with her doctor to find another option for her asthma. I want a happy and healthy child that can breath. It does’nt matter if a child has asthma when their dead. I understand alot of people have and are taking this medication. My question is will my child tell me her feelings before its to late. I’m not willing to take that risk, are you? Please listen to these warnings if you have a child on singular.

I’m in my late 30’s and I have taken Singulair and Zyrtec for 3 years. I have not had any thoughts of suicide or depression. I even took Singulair during pregnancy and didn’t have any suicidal thoughts, depression, or emotional outbursts. I have anxiety, but have found that Singulair doesn’t make it any worse. I’m a small person and very sensitive to most medications so I’m surprised to see this type of labeling. I think research should be done before we start condemning it.

I started taking Singulair a year ago. During the past year my depression definitely got worse. This is anecdotal, I realize, but I am not going to take Singulair any more. The SI became too strong for me to take this lightly. My pharmacist thinks that I am making too much of this story. Too bad. To err on the side of caution beats possibly losing my life to my disease.

I was just recently diagnoised as having ashtma. My doctor started me on singulair. I also treat depression and anxiety and have been treating with Paxil and have been doing fine for several years.
I will say that in the short time I have been taking the singulair, I have had a lot of anger, lacked control in some instances and had a hard time of letting go of the angers. I also began to isolate myself from others. Upon discussing this with my doctor, he pulled me off the drug.

My 6 year old daughter has been on Singulair for about two years. In the past several months she had been getting more and more angry and irritable. If the slightest thing would not go the way she thought it sould, she would yell and stomp around and be in a horrible mood for hours. My 5 year old son refused to play with her because he said “she is too mean and will just yell at me.” We tried to find problems in school or with friends, but couldn’t find a source of her anger, frustration, and irritability. We were ready to have her start seeing a physiatrist for anxiety and depression. The problem we were struggling with is that she didn’t seem to have all the symptoms that are identified with children suffering from depression. We searched many sources regarding children and mood disorders and nothing seemed to fit.

By coincidence, we didn’t get her Singuliar prescription refilled for about a week and a half. We kept forgetting to call it in and then a few more days passed before we picked it up. Without making the connection, we noticed that she started having really good days. She wasn’t yelling, she didn’t argue and cry like she had been, and she seemed happy for a change.

The day after we started her back on the Singulair, I read the article about the FDA questioning Merck regarding Singulair. My heart skipped a beat. I e-mailed it to my wife who quickly found an online forum from parents relating eerily similar stories about their child’s behavior while taking Singulair. We have not given it to her since and we now have our happy little girl back. We’re working with her pulmonolgist to come up with an alternative, but will not giver her Singulair again.

I’m sure Singulair has worked very well for many people. But, if you or your child are taking Singulair and are having mood or behavior problems, then please talk to your doctor and look at the possibility that Singulair is the cause.

I have a 10 year old son that has been on Singulair now for 6 years…he was always a loving and caring child. He and his sister have always been very close and loving toeach other…he was like a little daddy with her, you couldn’t ask for a better big brother!! He always made good grades in school and loved school, until this past year!!! He has made a complete 360! He started haveing school phobia is what the doctors called it along with anxiety and depression…crying all the time over anything. I took him to the doctor and they dignosed him with ADHD and put him on aderal…I cried because, I never wanted to believe he needed such a drug. The Aderale has not helped anything if anything it has only made it worse. He is even more irritable than he was. I think doctors are putting children on ADHD medicine was too easily…like it solves all the problems. I am suprised to hear this about Singulair!!! It makes me very angry to think that I thought I was giving my son something that would help him to know that is is only causing him to suffer greatly!!! I have been so worried and confused about what is happening to my loving and caring son!!!! I deffinately want to join the class action law suit!!!!!!!!!!!!!!!!!!!!!!!

Just recently my daughter who is 5 has started mood changes and isolating herself more at home. I am in utter shock about the news from Merck. She started Singulair about 4 months ago because of 1 excercise induced asthma attack. She’s a loving child but recently she yells/screams at her younger brother over nothing and is decreasing her desire to do Karate which she loved dearly. Mood swings in children can be contributed to other things but when my wife mentioned about a report linking depression to Singulair I started doing my research. I read the FDA report and Merck’s response today telling me I have to wait 9 months for further studies. I am a heathcare professional and spoke to one of our Pulmonologists today but he could not offer anymore insight then what is published already but he is not taking his patients off Singulair. I am torn over what to do. I sincerly appreiate everyones comments on the website and I am surprised reading how similar my daughter sounds to your children.

My 5 year old son was diagnosed with mild asthma and put on Singulair. Within a few months he began having uncontrollable fits of rage, displayed self-loathing behavior, had night terrors, and was inconsolable during these episodes. He became very destructive and was a danger to himself and our family. He even talked about killing himself and would say things like “I don’t want to be in this life anymore” and “I want to kill myself”. He would threaten my wife and his siblings and told them he wanted to kill them. It was a truly terrifying experience. Our pediatrician was clueless to these side affects and recommended we have our child go through a psychological evaluation. I knew this was not my child’s normal behavior so I searched the internet for Singulair side effects and found some message boards where parents just like me were writing about severe changes in their children’s behavior. I immediately took my son off the drug and within a couple weeks he was back to his normal self. He told us that he no longer has “that feeling inside of him”. Five year old children don’t even know what suicide is and to see my son talk like this was extremely frightening as you can imagine. He is a sweet, intelligent, loving boy who had never exhibited behavior like this until he went on Singulair. We have not seen this behavior after taking him off the drug and he has NEVER taken any other drug so it’s impossible to create that correlation with other preexisting issues. If we had listened to our pediatrician our son may have been misdiagnosed with ADHD or the like and further ruined by Ritalin or some other zombifying drug. I don’t know about you but it’s my belief that the pharmaceutical industry and practitioners in our country have already successfully created a “Prozac Nation” as I like to call it. This is dead wrong on every level.

If you go to http://www.medications.com/se/singulair you can read some of these experiences. You won’t believe what’s going on. There are over 30 pages of personal experiences on the site.

I’ve personally communicated with a leading professor of Pharmacology and Pediatrics at the University of Florida who I quote as saying “In response to your last comment, I thing Singulair has modest efficacy, and if we take all of our patients off this drug, they won’t suffer. This is not an important drug for pediatric asthma, as are inhaled corticosteroids.” Yet Singulair is the most overprescribed drug on the market today!!!!!!!!!

My 8 year old son has been on singulair since he was 4. He has been much more aggressive than his older brother, with many meltdowns. At age 8, he is now depressed, suicidal, aggressive, etc. He states “I can’t control myself.” I immediately pulled him off of the singulair after the news report and he is already much happier. We haven’t had any meltdowns or crying since he came off.

I started taking Singulair in September 2007. The drug worked well to keep my asthma and allergies under control. I noticed in October 2007 that I started feeling depressed and didn’t want to do anything. I thought these feelings were related to the fact that the school district I work for was out on strike. Once I started back to work in November the feeling didn’t subside, in fact, it became worse. In December I started having feelings of anxiety. I thought the anxiety was related to some issues my husband and I were having. In January everything calmed down except for me. I started flying off the handle, accusing my husband and friends of doing things they weren’t. I had a hard time cleaning my house, dealing with my kids, and keeping up at work. Throughout February and March I got worse and worse. To the point I thought my husband and I would split up. Last week I started having serious suicidal thoughts. At this point my friend called and told me to quit taking Singulair because she heard about the suicide and behavior changes associated with this drug. I stopped taking the drug 3 days ago and I finally feel like myself after 7 months. Hopefully as this drug gets out of my system I will be my happy go lucky self again.

I found out about all this in the last couple days. I have a 12 year old son who has had many of the same behaviors listed by other parents here. His grades went from all B’s to D’s and F’s, he is violent and mean to his brother, and is very detatched from me when we were always very close. I had everyone telling me it was becuase he just turned 12, but his behavior had become scarry to me with his lack of caring for anything. We are stopping the singulair as of tonight, and we’ll see if there are any changes. If not we’ll just know he is being a pre-teen. But if he goes back to who he was a year ago, then I will be very verbal about the dangers of this drug!

Our 10 year old daughter has had Asthma since she was 2 and we have tried a good deal of medications to control her condition, including Singulair. Singulair. Singular seemed to help with the asthma but it took us over a year to realize that it also caused dramatic agitation with her during bed time (about an hour after taking the meds). My husband and I thought it was defiance on her part. We elimated so many things from her diet trying to find the cause and finally figured tried the Singulair and once removed she imediately became a happy child again. Now we realize all drugs have side effects and they affect more than what is published! . Since then, were done with drugs and have significant improvement with holistic natural remedies.
What is the process for submitting complaints about side effects from a drug? when we told our doctor about the side effects they did not make a note in her file, they did not call the pharmacutical company…very interesting that there is not a system in place that we are aware???

I been on singular for almost two months,I noticed I can’t sleep actually affraid to sleep i have had this chronic cough for 10 months /w breathing problems I’m 44 and my health is going I been getting depressed becaused i been in the Emergency room 29 time since October of 2007,and not getting better, i get short winded just walking acrossed the parking lot,I don’t want to live like this,I get all kinds of bad thoughts, i wanted to leave my husband of 25 years, and accused him of cheating,i packed my house and got rid of my daughters cats.I do not like feeling like this Mean person.it seems like i feel angry mad and depressed,lost my appitite and can’t sleep.I call to make an appointment with my Doctor she recomended me to stop taking Singular.Now I need to try and save my marriage,and everyone i have been rude /mean /angry to. i hope this ugly person is gone. I don’t care for her.I want my life back too.

For those people that seem to be depressed on Singulair, try Zyflo cr. It is probably even more potent in severe asthma. It works differently than Singulair

CRITICAL THERAPEUTICS’ ZYFLO® RECEIVES DISTINCT CLASSIFICATION UNDER MEDICARE PRESCRIPTION DRUG BENEFIT Lexington, Mass., May 25, 2006 – Critical Therapeutics, Inc. (Nasdaq: CRTX) today announced that the Centers for Medicare and Medicaid Services (CMS) has created a unique Formulary Key Drug Type (FKDT) category for the Company’s asthma drug, ZYFLO® (zileuton tablets), under guidelines developed specifically for the Medicare Prescription Drug Benefit (Part D). This new category reflects the CMS’ adoption of the United States Pharmacopeias’ (USP) 2007 Model Guidelines. Under the new FKDT, ZYFLO is now categorized as a “Synthesis Inhibitor” based on its pharmacologic distinction from other anti-leukotriene compounds, including Merck’s Singulair®, which are grouped together in a category known as “Receptor Antagonists.” ZYFLO is the only 5-lipoxygenase (5-LO) inhibitor approved by U.S. Food and Drug Administration

My son started taking singulair at the age of 13 after claratin became an over the counter drug.Over the years he started to have sleeping problems and was dealing with depression on a regular basis.We went to the doctors for help and were prescribed drugs for depression which he said didn’t help.He started to isolate himself from family events,dropped out of high school and started sleeping a few hours during the day because he said he couldn’t sleep at night.
On the morning on January 4th of 2006 I was informed by the local police Dept when I reported my son missing that he had “passed on” This is every parents worst nightmare and let me tell you,what I heard next would have never crossed my mind.I thought maybe he was in an accident or somthing of course my son was a very careful driver but it doesn’t always have to be your fault.No,thats not what I heard,when I asked how they told me he had taken his own life.They had found him in his car with his hunting rifle between his legs at the tender age of 17.
All those years he was on a drug that appeared to be helping him…when all along it was eating at his mind.

My daughter has been on singulair for the past six months.Since then she went from beign a happy 3yr old to having mood changes,crying for no reason,and having night terrors almost three times a week.After we read the article on the 28th of march we took her off the medication.Now she is back to being herself again.We immediately noticed the difference.I’m glad that we did.It’s so uncanny how everyones story sounds alike.

I was put on Singulair Feb/March of 2006. I became depressed and started having nightmares. By the summer of 2006 I was isolating myself from all of my friends, I was crying daily the nightmares were now closer to nightterrors, 4-5+ a night. Some nights they were so bad I would wake up screaming and crying and obviously I was getting less and less sleep. December of 2007 I slit my wrist. I was hospitilized, there is no mental health illness in my family, I had never attempted suicide before. I went into counseling and did everything in my power to get better. I still had daily suicidal thoughts. Then while on vacation in Florida, with the nightmares and thoughts still occuring, I read in the US News front page article on Singulair. I stopped taking it immediately. I have not had another nightmare, night terror or for that matter a dream. I have slep through the night for the first time in over 2 years, I have not had another suicidal thought and I can laugh again. Although I still have to deal with the fact that I slit my wrist, I have a very huge and ugly scar, my children and husband have to come to terms with this as they held my arm together until the ambulance arrived. Singulair needs to be pulled off the market and Merk needs to be held accountable.

Tengo una bebe de 3 años y medio que toma Singulair desde los 2 años, ella siempre ha tenido un caracter fuerte pero ultimamente desde que cumplio los 3 esta mucha mas irritable, llora por todo, grita mucho, no se la puede reprender porque llora, a pesar de dormir 8 horas diarias siempre es dificil levantarla temprano para ir al jardin, no se si sea causado por el medicamento (ella no es asmatica, es alergica) pero en verdad este tema me preocupa muchisimo porque tengo 2 sobrinas que tambien lo toman. Ojala y el estudio se termine muy pronto y podamos estar tranquilos porque es un buen medicamento.

I have been taking Singulair since i was in the 5th or 6th grade( now a Sophmore in college) but it has always been the 5mg chewable child’s dosage, and never really had any sign of depression! I was a happy child engaged in school and extra curricular activities that loved going to school and learning! That is until my doctor bumped up my dosage this past year to the 10mg hard swollable pill! I started having anxiety attachs for no reason in the middle of the day! i would cry uncontrolablly for hours! I would over stress about school and work and friends and family and the littlest things would set me off! And even just recently i’ve been so depressed about school and relationships and work that i have thought of ending it all just to escape the pain and overload! please don’t take this caution lightly! Since i heard about these now studies i have stopped taking singulair and have been gradually been seing inprovements in my self confidence and behavior! This is real and yes not everyone may experience thses side afects but that doesn’t mean that they are not there!

My son was diagnosed with asthma at a young age (2 years old). We tried many medications and whatnot. He started singular at the age of 5 or 6. He is now 14. He is a great student, gets along very well with his younger sister, and is always upbeat. We haven’t noticed any depression or negativity. His dosage is 5 mg. So far, Singular has been great. We tried changing to something else, but his asthma symptoms increased. With this new information, we will be keeping an eye on him.

Thank goodness I’m not the only one.

My son is 10 and has had asthma since he was 2 years old. 2 years ago he was prescribed Singulair 5mg. It was amazing - he was off oral steriods and we no longer had visits to A&E.

However, I have noticed such a change in him. He has no confidence, sleep problems, anxiety and school phobia. He has gone down from the top of the class and often complains of headaches and dizziness. He seems to be often on the verge of tears and not as sociable as he once was.

I am stopping his Singulair medication today, I will post another comment if it makes a difference.

Remember that you take Singular instead of Prednisone. If you take prednisone, you will swell up, have a moon-face, feel hungry all the time, have osteoporosis [it reduces Calcium uptake], and prednisone paranoia.

Instead, you idiots curse at a one-off reaction that Singular causes suicidal thoughts in 1 of several 100’s of patients. If a medicine makes you feel better, PUT UP WITH THE SIDE EFFECTS or GET OFF THE MEDS.

IDIOTS.

Rob.

Suicidal thoughts in 1 of several 100’s of patients? Not so. See http://www.medications.com for evidence of what Singulaire is doing to many children.

I believe Singulaire is like Prozac, affecting children in a completely different way to adults. Look at the postings of the 550+ people under Singulaire on http://www.medications.com, look at the comments compared to their ages - a pattern emerges:

3-7 year olds become very aggressive
7-27 year olds become depressed, anxiety separation
27+ wonderful drug cures asthma/allergies
ple, look at their ages and a pattern emerges.

When my son became anxious, suffered panic attacks, depression, it took us 5 months to realise it was the Singulaire - the doctor thought it post traumatic stress following the first severe asthma attacks. By this time my happy son had turned dark, terrified, consumed by sadness, had lost 5-months of schooling, was suicidal. He was just nine.

Its not a case of ‘put up’ or ‘get off’ - if only life was so simple Rob.

]Elmo wrote, “He snorted and made a rude remark about people who want to find something to blame things on.]

As a mother, you must be so proud!

[Rob srote, "If a medicine makes you feel better, PUT UP WITH THE SIDE EFFECTS or GET OFF THE MEDS. IDIOTS."]

While you are clearly omniscient, others may actually need to read and learn about things. How does educating about possible side effects / sharing symptoms that many people are experiencing make anyone an “idiot”? How does one make an educated decision to continue/discontinue a medication without information? How on earth do you think we learned about the dangers of MANY drugs that have been taken off the market?

Our son started taking Singulair when he was 2 for severe allergic rhinitis and mild asthema (in addition to Zyrtec, which didn’t control all of his symptoms). He is 5 now. For the last three years, he has been an increasingly violent, difficult, defiant, argumentative, volatile child who has intense mood swings; one minute he’s laughing uncontrollably, the next he’s weeping over nothing. His doctor and therapist recommended that we see a psychiatrist to have him evaluated for bipolar disorder. As an aside, bipolar disorder used to be completely unknown in children. Because he has such chronic sleep problems, the doctor also suggested we take him off Singulair to see if it improved his sleep issues. Within a week, he was sleeping much better and was a calmer, happier, gentler boy. He suddenly could take “no” for an answer without trying to kill me (really). We thought that we were just in an unusual, calm window that would shift either to mania or intense sadness or both, any minute. We also thought that he was benefiting from better sleep. We were enjoying the rare reprieve. Four days ago, his springtime allergies really flared up. We gave him Singulair the next morning and by noon, he was in a full blown manic episode. I had to strap him into his car seat at one point to keep him from hurting either me or himself. It was then that we realized that Singulair might be causing his “bipolar” disorder. Of course, we stopped the Singulair. It is two days later and he a new boy. An hour ago I Googled “Singulair bipolar children” and got a few hits. I am stunned to read how similar other families’ experiences have been to ours. My poor little boy! I’m sure that many of you can imagine what our life has been like for the last few years.

As for Rob and his snarky comments. It wasn’t at all obvious that Singulair was the cause of my son’s issues. At 2 years old when he started, he couldn’t tell us how it was making him feel. Over the years as his behavioral and emotional problems emerged and intensified, we never linked it to this drug, nor did his doctors or therapists. I don’t know why you would have so much contempt for the folks posting here.

I am so glad I check this site out. It really explanins a lot. I have a 13 year old down syndrome daughter who has sinus and allergey problems. things were getting worse so the doctor bumped up her 5mg too 10 mgs of the chewables. Since she can explain things in her own words she acts out and she has started pulling hair every day not wanting to go to school and puking every day. Along with telling me she has an ear ache and headache I just assumed it was her sinus causing it all. I have been searching for a Behavior therapists to go to school to help out as things are getting that bad. But after reading this I feel so much better. I am taking her off this and will find something else. She is always going to be prone to upper resportory infections but she is haveing more and more. I feel so relived!!!!!

I would def. send e/o over to medications.com There are hundreds of kids going through ADHD & Bipolar symptoms b/c of Singulair Including My 11 yr old son
I would like to know how some ppl think it would be so easy to tell what S/E’s were from Singulair when their child is on 4 other meds at the same time?

My son is already dx’d with ADHD & poss. Bipolar I thought his symptoms were getting worse with age?? Now I know it was singulair we are almost 4 wks free of it & OMG What a difference!! we are even cutting back on his other meds!!!
Please report your S/E’s to the FDA!!!
this drug might be great for some but for many others It’s cauing ADHD/Depression/Bipolar type behaviors!!

I am a busy mother and wife who was a completely healthy person, no major medical issues ever with some season allergies and a mild case of asthma because of season allergies. I took Singulair for only three weeks about a year and a half ago and my life has not been the same.

After going to six specialist, they all now want me to go to Mayo Clinic.

When taking Singulair my symptoms were horrible aching in my legs, feet and ankles and the bottom of my feet would severely itch.

I stopped taking Singulair, but the symptoms continued and gradually got worse.

Now I have a severe case of hives and angioedema. The docs keep changing the allergy medication because it will work for a month and then stop. My other symptoms are horrible body aches, headaches/migraines, rage disorder (I have always been a very laid back person), anxiety, night terrors, blurred vision, positive ANA, thyroid antibodies are extremely elevated, consentration issues, and weight gain of 30 pounds (I was always very thin.

I have contacted the Merck Company. They were very nice to me, but have not done anything for me regarding the issues I am having. Basically they advised me to hire an attorney. I am more concerned about children being on this drug than hiring an attorney. Children are not able to communicate the way an adult can. I do not want to see anyone, especially a child suffer the way I am and have.

I understand not everyone will be effected in the same way, but Rob you need to be a little more caring and understanding. Maybe your attitude and remarks being so rude are due to the fact of you taking Singulair. I cannot imagine anyone having such a heartless reaction to other people, especially when you have no idea what others are experiencing.

Thank you for listening.

My son, A.J., was 17 and had been on Singulair on and off since he was 9 or 10. He started having psychiatric issues with depression and moodiness and TWO bouts with the chicken pox. He was taking it for asthma. The psychiatrist diagnosed him with severe depression but A.J. didn’t want to take meds because he was afraid that they would “change” him. I was ok with that. On October 2nd, 2007, the day that Merck made a “change” to their inserts, my son committed suicide. He was taking Singulair at the time. I don’t believe that Cody Miller’s suicide was an isolated case. It was most definitely an OBVIOUS case of Singulair related suicide as it was the only drug he was taking and had only been on it 17 days and had all the symptoms leading up to his suicide. How were we to know that a drug to help our kids breathe could affect their brains?
Rob, look in the mirror the next time you use the word “idiot”

Hi! I’m a teen and I was taking Singulair for about a year. I was a happy joyful young girl until i started taking this drug. I had thoughts of suicide and often put a bunch of pills in my hand and verged on committing suicide. I also isolated myself from my friends and became some what of an outcast. I stopped taking Singulair and became happy and popular. I really believe that this drug is linked to suicidal thoughts and/or actions. I was a monster. I was irritable angry and I had horrible tantrums for no reason.

Hi, I am 16 and I have been on singulair for about a year at 3 month intervals. I was surprised to find out there is a link between singulair and suicide because singulair has changed my life before singulair I had to wear long sleeves in the middle of the summer and couldn’t sit on grass or even run and missed on average a month and a half of school a year. Now I can run and even play softball and grow plants and only missed to 4 days to allergies so singulair is a miracle drug.

My 10 year old son has been on Singulair for almost a year. 3 months ago he started pulling out his eyelashes and eyebrows, was saying he hated his life, calls himself a freak, says he is always sad and never happy. He’s been off this stuff for a week and a half and I believe we have seen moderate improvement in his behavior/attitude. The worst thing that hasn’t changed is the hair pulling, it really is affecting his life and the whole family. I am hoping this subsides soon.

i joke with my girlfriend calling singulair “my angry medicine,” she doesn’t think it’s very funny though. about a half hour after swallowing the pill, i am more angry and more irritated than ever for absolutely no reason. i’m typically a very calm easy going guy but this medicine makes makes my mood very mad, i just can’t control the anger i feel, i never feel or have every felt that way except when taking singulair. i have been taking it for about a year but only once or twice a week (when i get stuck being around animals) the asthma relief it offers is good but the psychological effects are horrible. i couldn’t imagine taking this medicine everyday. i’m sure it screwed a lot of people up for life. it must take a huge toll on body and mind.

I have been on singuliar since 1999. My life has been turned upside down. I was angry for no reason all the time. Severly depressed, tremors, all of the side effects that that was mention on the fda’s webpage about the meds. I have suicidal thoughts but have not attemped it. I want more information on class action lawsuits. Right now, it is one firm that are looking for people who have down themselves bodly harm. But what about the other side effects. I think they are just as bad!!

Thanks for allowing me to share.

My 6 year old was put on Singulair but I just pulled him off of it. He was having stomach problems at night after I gave it to him such as complaining of a stomach ache and very often vomiting. His sleep was very disturbed also. Last night I didn’t give him his Singulair and he slept like a baby. Within minutes he was out like a light. My son has also developed a very disturbing habit of eye rolling/twitching and I don’t know if it’s somehow related to the use of Singulair or not. I would not recommend this product to anyone although the doctors are so quick to push this onto people. Now I’m reading this medicine is a cause of behavoiral problems and can actually make users suicidal. No thanks! What the f.d.a. won’t approve. What a disappoinment the f.d.a. and what a disappontment this medicine turned out to be. I pray my son does not suffer any long term effects of this.

I have two children, ages 13 & 15 who have been taking Singulair with great success for over 2 years now. When I (42 y/o female) developed out-of-control allergies earlier this year, my doctor prescribed me Singulair since nothing else on the market had helped.

After 7 weeks on this medication, I was instructed today to discontinue its use. Although it has helped my allergies considerably, I cannot begin to tell you my anxiety and depression symptoms have multiplied. I am currently on a mild anti-depressant as well as an “as needed” anxiety medicine. My first week on Singulair was noted with significant anxiety and panic attacks. They did subside as I began to get used to the medication. However, they never completely went away. Now they have become constant and strong, and the increased depression have triggered the m.d. to stop the meds for now to see if they subside.

I do not worry about my children on the meds, as I believe they would have had problems before now. Plus, I might be predispositioned for anxiety issues only to be increased by this med. Hopefully, I will know after discontinuing the use of this med for a couple of weeks if this was actually the cause.

Our doctor just perscribed Singulair for my one year old today for his asthma - has anyone given it to a child so young? He is already on an inhaled steroid and a “rescue inhaler” fairly regularly.

I am a thirty five year old woman, who has been on singular for… maybe a year? Maybe not quite a year. I also take zertec. The combination of these two drugs is an absolute godsend for me. I can breathe so much better now! I haven’t been able to breathe this well in years, and that is no exaggeration. I would say I am a person who struggles with “rage management” issues, and just gotta say, the Singular does nothing but make me calm. I don’t feel depressed, I don’t see myself isolating away from people. I’m doing great on this drug! I have noticed that the half hour after I take Singular I am a little less coordinated, and I tend to type even more dyslexic than usual. Nothing unmanageable. I go back to normal after about a half an hour. From reading these comments, it is clear to me that Singular may not be doing wonderful things for children and teenagers. But, as a grown woman, I am so happy to have found this drug. I am scared to death that all these complaints about the negative effects that some children and teenagers are having with Singular will cause the drug to go off the market. I understand that suicide is a serious thing. I just recently lost my cousin to suicide (and she never used Singular). But, please, please, please! I really hope that the end result of all these comments all over the internet is not going to be that Singular gets taken off the market, and I go back to wheezing terribly, to the point where it is painful, on a daily basis, again. Now, that would make me start to feel suicidal!

Hi i am a 52 year old mother of three. My youngest son is 14. He has been taking Singulair for about 3 years now. He has other problems like adhd and ocd(obsessive compulsive behavior) and is on meds for those conditions also. Recently he has been sleepless at night and told his father that he is afraid to sleep because he has bad dreams. He has always been a straightforward bright kid and i was really concerned. I researched all the meds he is on and NONE of then causes bad dreams and sleeplessness EXCEPT SINGULAIR. I was floored that a medicine that is not a psychatrict medicine and is just for seasonal allergies and asthma prevention could cause that. I took him off it and much to my suprise he is like a different person. He says that the only dreams he has now are the REGULAR type and not anything like before. I am really angry that a med like this could be put on the market without EXTENSIVE testing and now i just heard that the fda has recalled singulair from the market. Good riddence! there are a lot of other meds like it that do the same thing for ones asthma and allergies and are safer. I will definatly be going to the doctor to ask him.

My eight year old son has been suffering adverse reactions to singulair for years. He started taking it for asthma at age 3. During the last few months, following a history of anxiety, aggression, irritability, poor attention, low frustration tolerance and self control, restlessness, and detachment (to name just a few psychological symptoms) he began showing definte symptoms of depression: withdrawal, telling us he always feels angry and sad, saying “nothing is fun anymore”. HE IS EIGHT YEARS OLD and didn’t even want to go to the movies or have friends over to play! It was only recently we learned Singulair could possibly be the cause and took him off. Within days his mood began to lift. He has been Singulair free for a week now and is gradually becoming a different person and I feel like I am getting to know him for the first time. He is looking forward to playing soccer (which he quit 1 1/2 years ago). He hums to himself. He smiles.

My cousin had a similar experience with her child. I have been in contact with others who have been through the same thing with their children.

I am convinced that this drug causes adverse reactions in some individuals. And yes, it was very effective in treating my son’s asthma. I do not believe it should be taken off the market but I do think it should be used with EXTREME CAUTION in children. Adults are better able to identify their feelings. Children can’t do this so well. Parents often attribute adverse reactions to developmental stages a child is going through if the timing happens to coincide. It is very important that this drug be studied further to find out why this is happening and what can be done to prevent more harm. ANY possible adverse effects MUST be publicized AS SOON AS THEY ARE REPORTED so physicians and parents can know what to watch for. I am not an advocate of taking it away from side effect-free people who derive a benefit from it.

We should ALL agree that the physical and mental health of children must be protected and we should all advocate for change to the medical system that ensures this.

I have been taking Singulair for a while now and it has helped my asthma dramatically and I have to date had no negative issues as mentioned above. Most adults especially females if they are going to develop anxiety/depression issues do in their late 20’s to mid 30’s, I developed anxiety disorder when I was 30 with frequent “full blown” panic attacks, also my PMS symptoms became dramatically worse when I was 31, I have since been diagnosed with PMDD. Had I been taking Singulair it would have been easy for me to blame the medication on all of the aforementioned symptoms but I wasn’t. Also my 14 year old son does not have asthma and when he turned 13 and still to this day sometimes I feel like choking him, but I do know it is just normal adolescent hormones, they do change a kid a lot. Just simply saying anxiety/depression, hormonal disturbances, etc. is not that uncommon of a diagnosis for young and middle aged adults, but I am certainly not saying the medication is not the cause of other peoples symptoms. I hope when the studies come out they will give us new info regarding the connection to Singulair and suicide if there truly is one.

my son was on singulair for almost 4 years for asthma. it turned my beautiful, happy son into someone i no longer knew. he was easily agitated. angry more so than not. he would become upset over such little things. he couldn’t sleep. even violent at times. by chance, i got into a conversation with a young woman whose brother was also on singulair. she described the same behaviors in her brother. i took my son off and saw him return to the boy i knew. happy again. easy going. i just thank God we got him off of it when we did. doctors have tried to put him back on it several times. i have told them about the side effects my son experienced, and they just ignore me. so sad that parents aren’t told about this when their child is put on this drug. why won’t doctors acknowledge these side effects?

Parents United for Pharmaceutical Safety and Accountability is an advocacy group comprised of parents whose children experienced devastating adverse reactions to Singulair. We are a comprehensive source if information on the side effects of this drug. We are not trying to have the drug pulled off the market, but we ARE working to educate the public about the side effects of this drug in order to prevent others from suffering as our children did. We are currently conducting a study of children whose adverse reaction to Singulair was misdiagnosed. Visit us at http://www.parentsforsafety.org.

My daughter is 7 y.old and has been taking Singular for over a year, so far so good
marta

My little brother started taking this drug about four years ago. within days he was not the same kid. thinking it was just normal teen anxiety every one looked past it. About a year ago my mother, frustrated to the point of depresion herself,took him to a psychologist. They put him in sleep clinics, nut houses, home schooling, ect. Finaly one doc said oh by the way, “singulair may cause depresion, anxiety, social withdraw, ad suicide”. they aparently new about this for a year, but never relayed this to the people taking it. he was taken off that day, within a week he was normal again.my question is what does the F.D.A actualy do. tainted food in our country all the time, meds that cost a fortune because of all the “testing” turning out to be worse than what there suppose to treat. Im sure this drug has helped alot of people, but it stole four years of my little bros. life put my mother through hell. Now the F.D.A. is looking into it, but i can not have any confidence in a department that cant stop vegetables covered in crap from entering this country. Something has to change soon, for all our sakes.

In July my daughter called me beside herself because our grandson was totally out of control again. He is only 4 and had been talking about suicide and killing people he loves very much. We all know this is not normal for anyone that age. He had many other problems, such as throwing fits for 30 min., arguing and angry 80% of the time and compulsive behavior that is too weird to even
describe. She was a phone call away from a therapist when I found the “POST A NEW SIDE EFFECT ON SINGULAIR” website.
Needless to say I was horrified at the information I found! There were so many people with children having the same symptoms as he was, that I couldn’t believe what I was reading. She took him off the Singulair and within 3 days he was such a calm little boy. It made me sad, glad and furious all at the same time; to think what he must have been going through in his own mind had to be very frightening for him. I saw such a peaceful look in his eyes…Springfield, MO KY3 tv station ran an investigative report on this drug on Oct 2 and had a very good response from it. They interviewed my daughter and her main goal is for labels to be corrected. They need to put on them what they have NOW added to their website. Possible side effects: SUICIDAL THOUGHTS AND SUICIDE, for starters.
Just wanted to put in my 2 cents worth for anyone in doubt, that this drug CAN cause very serious side effects especially in children!!!

My 14-year-old daughter was prescribed Singulair for asthma/allergies about a year ago. Since that time she has had uncontrollable rage against herself. She literally begs me to hurt her while she is hitting herself. She has thrown herself on the ground like a 3-year-old at times. I attributed this behavior to raging hormones and normal teenage angst, but recently she started talking about suicide. The last straw was when she started to describe how she wanted to kill herself. I immediately got a doctor’s appointment. On the day of the appointment I grabbed her Singulair bottle, which was prescribed by her allergist, so that I could ask ther general practitioner to refill when suddenly I remembered reading the literature a year ago that mentioned depression/suicide (thank you God). The general practitioner agreed that there has been some discussion about depression and suicide in teens and immediately took her off of Singulair. I am now going to send her to a counselor to make sure that we’ve adressed the real cause. I have no doubt that Singulair had something to do with it because her change in behavior occured shortly after she started taking Singulair.

My 5 1/2 year old son began taking 4mg Singulair in the p.m. and an inhaler (asmanex) in the a.m. We were still having trouble controlling the asthma and his Sing dose was raised to 5mg. & within 1 week of the increase he began having terrible facial tics and aggravated behavior (defiant, poor listening, easily frustrated and angered) The tics were in the form of opening and closing his mouth, as if you were trying to clear your clogged ears after a plane flight. This caused him much pain in his jaws and facial muscles, so he would tic and then cry as he was in pain. This ramped up his anxiety and it made the ticking worse. He has been off of all asthma medication (cold turkey) for 5 full days. He has episodes where the tics happen for 10 min -1/2 hr, other times during the day it is one here and one there. He does not want to leave the house to do anything, even his favorite activities. Thank god I found this site (and others like it), as I got some answers and some hope. We went to see my cousin this week who is a neurologist and he never heard of the correlation of Singulair and neurologic side effects like these. He said that (hopefully) the medication side effects will cycle through and resolve the ticking and behavioral changes. If not we are probably looking at a Tic Disorder which is in the Tourettes Family.He put my son on a very low dose of Klonopin to mellow out his anxiety and help reduce the tics, but has only been on it for 1 1/2 days and it usually takes a wk or 2 for full absorption and results.I have since sent him and my pediatrician and allergist links to this site and others. I think that I see some improvement in my son, yesterday I thought he did better and my husband thought it was a worse day, I think we have totally lost our perspective and objectivity on this. If anyone out there has a time frame on when they saw significant recovery and positive changes I would love to hear from you. This is a total nightmare and if it is this drug, someone is going to pay. My prayers go out to all who are going thru this.

Hi Stacy
You are not alone in this..
You can visit my blog where i have wirtten our experience of my 5 yr old taking singulair.
By the time I finished writing the blog and went to pick up my son, he was in serious trouble at school/day care.
He was saying to his teachers he would cut himself and chop his hands off…
We stopped singulari immediately and it is only 4 days. But within 24 hrs we could see the change. Today he is completely back to self. I think you should discuss this with his doctor.

Hi Everyone,

My son is 4 years old and was prescribed singulair to help him get through the winter, as his asthma is always really bad during the cold months. Within a few days of taking singulair he was much more irritable than usual and within weeks of taking the drug he became completely aggressive, unreasonable and confrontational. At first I put it down to feeling unwell with a cold, but the behaviour continued to get worse and even his pre school commented on his terrible behavior. They wondered if something traumatic had happened at home to cause the changes in a normally happy little boy. We weren’t warned about the side effects by the doctor, but i finally took my son off the drug and he was back to normal within weeks. For some people singulair might be a miracle drug, but doctors should issue warnings to parents about the potential side effects and behavoural issues associated. They say these side effects are rare, but seem to be more common than the drug companies may be admitting.

Best of luck to you all,

Kate

In 1998 my 18 year old son David started taking Singuliar as a means of controlling his asthma. Over the next three years my son experienced all the classic symptoms that have been associated with Singuliar poisoning. Behavioral problems, tics, shaking, depression, every nightmare a parent could witness a child going through my wife and I witnessed. In and out of mental hospitals, emergency rooms etc. The nightmare ended in 2001 when my beloved son comitted suicide. I know that Singuliar was the agent that took my son. Merck should be held accountable for not reveling the side affects of this horrible drug.

There are so many details I could provide as to what happened to our daughter having been on Singulair for about nine years, but I’ll keep it brief here and let anyone who wishes to contact me about what my family went through, to feel free to do so through email. My husband and I almost lost our daughter to suicide, as she thought about it 3-4 times a week, she now reports. She is 16 and was on Singulair for about 9 years. My husband and I are SO grateful that we finally figured out what was causing our beautiful and bright daughter to become so unmotivated, miserable, lonely, depressed, having low self esteem, not feeling loved or worthy of love, anxious, nervous, having nightmares, suicidal, and wanting to sleep her life away. We welcomed the daughter that we knew we were missing about a month after she stopped taking Singulair, which was the end of September 2008. She can now verbalize how she felt, afraid to destroy me and my husband before, and said that the only reason she didn’t take her own life was because she “didn’t have the guts to” and she was able to talk with a very good friend who convinced her that living was better. She had been in therapy twice during the course of the last several years, but never really understood why she felt the way she did. I hope nobody else has to suffer the way our daughter and family have because of this or any other medication. My heart goes out to the families of those who’ve killed themselves as a result of taking this medication. Hearing the devastating news of one particular tragedy caused us to research the claim against Singulair’s side effects and saved our daughter’s life!

My son has been on Singulair since he was five and he is now 12 years old. We haven’t experience a single problem with the medicine. It was a godsend because he was getting breathing treatments every four hours for months on end- then after Singulair, he went an entire YEAR without a breathnig treatment. He only needs his albuterol a few times a year. He is a great student, sweet kid, and superior athlete. He is on the chewable 5 mg with Claritin as needed- this has been a magic pill for us.

I posted on this site in October about the Parents United advocacy group. I am posting again to state that it is my belief that Singulair is not an appropriate drug for children in light of the potentially devastating physical and psychiatric side effects.

Not enough research has been conducted with children. To my knowledge, only 1504 children were given this drug in the clinical trials. Last year about 31 million prescriptions were written for Singulair. The largest popluation taking Singulair is children.

To my knowledge, the mechanism by which Singulair causes both physical and psychiatric side effects is unknown. Nor is it known whether or not this drug can cause permanent damage.

The risk benefit ratio of this drug is terrible. It has not been proven to be the most effective treatment for alleriges or asthma. Yet doctors continue to prescribe it to young children, sometimes without warning parents of the possible side effects.

There is no doubt in my mind that Singulair made my child mentally ill. There is no doubt in my mind that I might have lost him had I not learned about the updated side effects and stopped giving him Singulair.

Just wanted to thank all the folks for their comments. Have been taking this drug for about 2 weeks and am very tired all the time. I can see where this will lead to depression because I am to tried to do anything. I am 64 and retired. Will stop taking this after reading these posts and go back to Zyrtec.

I’ve been taking for a week now and do notice a difference in mood. I’m 37 and have had asthma since I was 19. First couple of days it made me tired but I seem to have gotten over that and I am able to manage the mood change. I guess I should describe the change. It has made me more mellow than usual. That’s about it. But I could see how in someone prone to depression this could add to that. I kind of like the way it settles me down. But I would be very careful giving this to my kids.

I have to add that so far my breathing has been incredible. I don’t ever recall being able to breath this easy. So mood swing worth it to me. I’m starting to think I may have had asthma all my life and not known it.

41 y/o caucasian male, taking Singulair for allergies. I did not hear of this until recently, but figured this out on my own. I would be very, very angry and irritable, anxious and have suicidal thoughts. I have no other history of mental illness or depression. I have TESTED this on myself by going OFF the medicine, then back ON the medicine for weeks at a time, and for ME there was an absolute 100% correlation. I did my best to rule out other stressors or causes, and took into account external factors (work, family, kids, etc.). I had definite side effects of anxiety, depression and suicidal thoughts. That being said, I loved how the medicine helped my allergies, but I would rather have the allergies than have the moodiness, anger, irritability, depression and dangerous thoughts.

Thank all of you for your stories. I am a mother of a 4yo boy and happened on your site just looking for answers. My son has been on singular for 7 months and is a different child. He’s always been so friendly and outgoing and now is more reserved, having meltdowns over the least little thing. We contributed some of the behaviors to being a new big brother. However, frequent headaches and (the newest symptom ) tics really is not explained by this. When I read these stories I knew the reason without question. My son was hospitalized in July for asthma and put on singular. Our Dr. is now getting ready to do CT scans to rule out other problems when I truly believe that takinging him off this one medication will solve our problems without invasive testing. Thank you, to all of you with your stories and to all of you saying we are looking for blame, your correct! When your child is not themself any good parent tries there best to find any reason they can for the problem and the best solution as an answer. Thats just what parents do.

My wife took this medicine and went into a total tailspin within a week of starting. depression mood swings rage. she said she felt as if she was outside looking in. almost left a job she loves because she couldn’t cope. she has stopped taking it and life is good again…..very dangerous drug.

Has anyone had children who suffered other symptoms and wondered if it could be the Singulaire? I’ve recently taken my 4 year old it after a serious of mysterious infections - they appeared to be kidney infections, but at the hospital they tests didn’t add up. There was clearly something wrong in her blood tests but the urine tests didn’t show infection and the scans on her kidneys seemed fine (we were hospitalised 3 times over a 2 week period). She’d also been complaining of pins and needles in her legs, and then we had a couple of nose bleeds that took over 15 mins to stop. And she was permanently tired - not sleeping well and having nightmares. I read in the Singulaire advertising that all of these things could be related to the drug and decided to stop her treatment - she’s immediately improved. I am worried about her asthma as the Singulaire made a big improvement for her, but now I want to stick to her inhalers and see if we can keep her well that way.

I have been on Singulair since Oct 2008, now I have been getting pins and needle feelinns in my legs arms feet, total numbness on several areas, The Doctor has told me i now have vasgalitist and now im on 18 months of chemo.
all stated when I started to take Singulair for my astma.

My wife has been on this drug for 40 days and I threw the entire bottle in the toliet and flush that shit away after reading this website. She has had periods of extreme anger, crys and the drop of the hat, and is very depressed. This is a total change in her behavior and not the women I have been married to for over 35 years.

Has anyone filed a law suit against the manfacture about this? Why has this stuff not been pulled off the market? Singulair was great for her allergies and asthma, however, we cannot handle the side effects. We will find something else to use.

Thank God we found the website. God Bless all of you for posting your comments as it saved my wife’s life.

My wife has been on this drug for 40 days and I threw the entire bottle in the toliet and flush that shit away after reading this website. She has had periods of extreme anger, crys and at the drop of the hat, and is very depressed. This is a total change in her behavior and not the women I have been married to for over 35 years.

Has anyone filed a law suit against the manfacture about this? Why has this stuff not been pulled off the market? Singulair was great for her allergies and asthma, however, we cannot handle the side effects. We will find something else to use.

Thank God we found the website. God Bless all of you for posting your comments as it saved my wife’s life.

Hi, My name is Ashley I suffer from indoor & outdoor allergies. I recently went to a allergy Doctor and they put me on several different allergy meds from an inhaler, which I dont like because it makes me nervous so I dont use it and some other meds like Alerga D and singular is one of the meds as well. The reason Im writting this is because I started all the meds because I was having sinus trouble like sinus infection also I had two ear infections before nay of the meds and I was suffering from all thes infectuons getting in my lungs and all then I found out I was allergic to cats which at the time I had two so I got rid of them but my question is if I was having ear infection and also i have problems with anxiety and sometimes depression why would this Dr. put me on this Singulair. I mean gosh one of the side affects it self is ear infection which I have right now as we speak and this one is worst then the other two that i had 6 months ago. I have been on the meds now for like 5 months and since then I was like yes no more infection and then bam here it is another sore throat that leads to an ear ifection then goes down to my lungs. Not to mention that I have notice that my anxiety is getting worst and the xanax that I take for it seems not to be working and I find myself more and more scared to go anywhere even to the grocery store and yes I have thought about suiside a couple of times but thats only when im suffering from all the infections and also im having trouble with my marriage and this anxiety feeling is not helping. All im asking is why would a Dr, put me on something that causes side effects that I was already having before she put me on it. I mena my god want that just make it worst. I dont get it are these Docs getting paid by the company to promote and perscribe these drugs or what Im going to go talk to my doctor about this and find out what I should do. I love my life but sitting here with the wic thing in my ear doped on on pain meds for all the ear pain im having I wonder what are they thinking. I have an appointment with my ENT tomorrow and Im going to ask him if this is just another ear infection that im prone to getting at age 30 or could this have been brought on by the drug. Im not just going to stop taking my singulair because of something i rea don the internet I’m going to first talk with my doctor and see what they have to say. I sure hope i can get past this I this. It’s funny for the last few months I have been telling the people close to me take me out to the pasture and just put and end to this mess. I also have been feeling like my friends arent my friends like they dont really like me even my fried who is 1,300 miles away who I have been friends with for 20 years. I talk to her on the phone all the time and for the last few months I been thinking oh she dont like me. I wonder if this could be that singulair making me not think right or something. Im not one to point fingures you know. Im like life is life and maybe these are just stressfull times for me and I have a histpry of depression so maybe this is just a phase. I remember at one time I was taking Remeron aka Mirtazapine but I got off of that real quick once I realised that I had lost all emotions. I mean that drug made me not care about anything I like a freakin zombie. I want to do whats best for my health and I really feel that instead of all the drug companys trying to make the all mighy dollar right of the bat with there pretty million dollar commericals they should really do there homework because this is our lives there talking about here. This is not some video game where once you loose a life you can just throw in another quater. I’m going to go ask questions and hope that I get some answers. Thanks current singulair user.

I have been on Singulair for a week. The past 5 days I have been PSYCHOTIC!!! I have had many thoughts of killing myself, killing others because I can’t handle anyone around me, severely moody and full of rage! I just thought today that it may be the Singulair so I researched the internet. I am OUTRAGED at these drug companies! I will be writing and calling Mereck. Now I need to find something to help my miserable allergies. I have started allergy drops and I’m going to take natural things only from here on out.

These stories are alarming. Could it be the phenalynine (probably not the right spelling) in the chewable pill for children that is causing the side effects and not the singulair itself?

However, I’m 68 years old, finally my asthma which I’ve had since child, has become unmanageable without prednisone, which makes me nuts! However, I have experienced the side effects of pins and needles in my feet, and bad dreams and problems sleeping. I’m also mildly depressed. Im in the process of eliminating anything in my diet that might add to this, and excercising - I am breathing better, though my muscles feel very weak sometimes and I’m listless. I’m going to give it a few more weeks - or maybe less - and then try to go on just Zyrtec and Nasonex and back to Albuterol when needed and see if that helps. What a shame that there are these side effects - but, for me at least, they are very real.

My name is Corina. I am 16yrs old. My little brother commited suicide January 30th 2008 and he was on Singulair. He had severe asthma. He was a straight A student, in the gifted program at school and he played on the football team. He had so many friends and was in 8th grade. My brother started changing once his dose of Singulair was upped a few months before his death. He began isolating himself and demonstrating aggressive behaviors. My family has no reason to suspect or think that his allergy medicine could have been causing this change in him, however we were NOT aware of any of these symptoms. Unfortuantely my brother died only at 14, and 2 months after his death is when we became aware of the side affects of singulair. I know in my heart that this is the reason why my brother took his life. He was not a troubled child. Over the past year and a half more and more side affects have been added to the label and i believe that this medicine should be jerked off the shelves. My brother died as a result of this and my family will never be able to get him back. We need closure and looking back if we would have been aware, we could have saved my brother’s life. It has been the worst thing to ever happen to me in my life.

I’m a 25 year old female without previous issues with clinical depression or severe anxiety. I was on it for about a year. I got more and more depressed and anxious the longer I was on it. I ended up in therapy and they tried lots of antidepressants on me but nothing was working. My friends told me I was “inconsolable.” I just spiraled down, lower and lower to the point that I could barely function because I was so miserable. I was incredibly depressed, anxious, and even somewhat suicidal. If any of you have read the Harry Potter books, it was a bit like being in Azkaban where I felt like I was drowning in bad thoughts and reliving all the bad things that had ever happened to me and unable to experience any proper degree of pleasure from life. A few weeks ago, my doctor discovered this new info about the drug and advised me to try going off it. Within a week, the physical symptoms of depression lifted and within 2, I was mentally healthy again and no longer clinically depressed. My psychologist was amazed really. She said it is virtually impossible to recover from serious clinical depression that fast… unless it was the drug. I am very interested in pursuing legal justice via a class action suit. This drug basically robbed me of a year of my life I’ll never get back and put an immense stress on my personal relationships. The people who released this drug without a proper trial should be held accountable.

My daughter who is 14 has been taking Singular since it literaaly came out on the market, but a year ago she began to become violent, angry constantly crying and aggressive. This year she began to do to self inflict her body with burns and cuts. At first my husband and I thought the angriness was from teenage hormones but when she began to cut and burn herself we knew more was going on and sought help from a professional at a mental facility (no we didn’t have her committed) but right before the appointment I typed in Singulair on the FDA.gov website and found the article about singular. Loaded with this information that I printed out we went to the mental facility. Now we are waiting on help. Pray and wish us luck.

My 7-year-old son has been flying into fits of rage off and on for about a month. Tonight after calming him down I told him we needed to pray to God for help so that he could stop acting that way. My husband and I were discussing what could have caused this sudden change in behavior and thought of the Singulair he had started taking about 6 weeks ago. He googled Singulair and rage and immediately told me of the side effects. I think our prayers have been answered! I’m looking forward to having my good boy back!

I decided tonight to do a google search tonight to see what the adverse side effects are of Singular. I’ve been having a great deal of problems for the last two years now since I’ve been on Singular, but never associated my problems with Singular until tonight. I finally started to wonder, which led me to this research on line. I am in shock after reading all of the side effects, but it’s all making sense now. The first year I went on Singular, 2007, I had a lot of breathing problems AFTER going on it. I just figured my mild asthma had gotten worse. I Always felt short of breath, or that I couldn’t catch my breath. Even when just sitting and watching tv. Sometimes I would even wake up with it in the middle of the night; unable to catch my breath. I think I had about 3 ER visits thinking that maybe I was having heart problems. It was very, very scary when I felt like I couldn’t breathe. I have also experienced a great deal of anxiety. Of course feeling as though you can’t breathe, does only make the anxiety worse. But these problems were coming on when I felt perfectly calm, watching tv, reading, sleeping. So my doctor of course diagnosed me with Anxiety and gave me Ativan. I went off Singular November 2008 because I was pregnant. We miscarried February 2009. But in that time, I did not have any breathing problems what so ever, nor did I have anxiety problems. Right after I miscarried I went back on the Singular. My breathing problems have now gotten worse, my allergies have gotten worse, I always seem to have a lot of nasal inflamation, my anxiety has gotten worse and I’ve gone through many, many crying spells. The first couple of months, it was a matter of being sad over our miscarriage. But this is now 8 months later and I’m going through deep periods of depression along with crying spells in a way that I have never experienced my entire life. And just last night I woke up at 3am trying to take a deep breath, only felt as though I couldn’t I had to sit on the side of my bed for quite a while and wait for it to come to me. After my episode last night, I decided to do some research, and I truly now feel that Singular is not the drug for me. I’m sure it has helped countless numbers of people and at one point, I swore by it as well. But all of a sudden, it seems to have turned on my system. Good Luck to you all!!! May you all find what works!!!

My son is 6 years old and he was put on Singular to control his asthma. It has made him hyper and nervous. In the week he has been on the medication, he has started to bang his arms on the table, blink his eyes constantly, bang his head into the chair and his chest into the table. These seem more than just coincidences to me. My wife and I took him off the medication. Hopefully there is something else out there to control the asthma.

My husband has just been prescribed Singulair for easing symptoms that the doctor believes are caused by allergies. After reading these letters I am aghast that this medication is still on the market! I want to thank everyone for their input. I have shared this information with my husband and he has decided not to take this. Has anyone here been treated for allergies and had good results with other meds? I am SO glad I decided to research this BEFORE he started taking Singulair. The poor economy issues have caused serious problems with my husband’s business. Had I not come across this blog prior to him taking this med, and he went ahead without this knowing about the (casually mentioned in the script contraindications) depression and anxiety, we may have chalked it all up to actual life stresses. Many thanks for enlightening us before he started taking it. :O)

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    Last reviewed: By John M. Grohol, Psy.D. on 12 May 2008

 


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