Thanks for the link to the child and ten anxiety resource website. I suffered with OCD as a teen and I am afraid that my son will, too.

The following commentary reply deals with TRPV neurons. And how it relates to the side effect issue for psychiatric drugs such as anti depressants, atypical antipsychotics and other anxiety targeted medications. This nerve could be the area that eventually will give a cure for diabetes in a few years, if all continues to go well on the research front. Atypical antipsychotic patients (APP’s - the drugs that is) have developed diabetes and hyperglycemia from taking these medications. And thus the Toronto Sick Children’s Hospital TRPV 1 neuron research discoveries hold a lot of importance to them. Thus the reason I wrote the following commentary for your blog. I divided this commentary into two parts, for space reason. Part 2 I put in the reply section of the adjacent article entitled:”Trend in ADHD Treatment 2000-2005″ the article found in this blog, that is. Also, this two part commentary can be read along with an earlier blog comment or reply comment on the “Bad docs working on drugs” article, found in previous entries of the Psych Central web site. Thank you for your consideration. Hopefully the information will be useful and important.

TRPV1 Neuron - Pain and Light
Potential good news for diabetes and the Atypical antipsychotics

When the human body, that is the human organism, moves through the environment, it encounters situations that bring on pain. A car accident injury, a burn from a frying pan accident, a cut from climbing a rock, ect. Pain serves as a learning tool for the human being to preserve its body from being injured. The neuron TRPV1 conveys the pain signal to the brain. But also TRPV1 neuron conveys the effects of light to the brain. Pain and light phenomena run confluently along the TRPV1 neurological lines. And the fascinating issue, impulse and feeling of pain serves primarily the human body as it moves through the environment. Light, that is intimately tied into the functions of the mitochondria as the organelle supplies the energy to the body for propelling the body through the environment. And that is because, the alternation between daylight and night can determine what functions the mitochondria possess. Regular oxidative phosphorylation as a mitochondrial function along with a second anaerobic function of involving electron transport chain uncoupling. Daylight appears to be associated with mitochondrial oxidative phosphorylation. Night time darkness with electron transport chain uncoupling processes, (processes tending toward a more pronounced participation of anaerobic cytoplasmic glycolysis,), that are the hallmark of the diabetes condition, especially when pancreatic islet mitochondria experiences such uncoupling phenomena in an evolving diabetic condition. And these being atypical antipsychotic (AAP) induced conditions of diabetes also.

The following quote from Richard Fiddian Green’s article, “pH regualtion of ATP synthase activity: evolutionary biochemical bedrock?” 28, June 2004. The journal -Chest. The quote : “ATP synthase catalyzes the synthesis of ATP from ADP, Pi and H+ by mitochondrial oxidative phosphorylation in the presence of a protonmotive force. ATP synthase reverse itself on occasions inhibiting ATP resynthesis and instead pumping protons out of the mitochondrial matrix to re-establish and/or maintain its alkaline pH and the protonmotive force. In so doing it utilizes energy and protons derived from the hydrolysis of existing intramitochondrial ATP stores. The net effect is reminescent of the division of labour between alternating light dark phases of photosynthesis.”
End of quote.Diabetes, which is well characterized by insulin resistance, glucose dysregualtion and most importantly, mitochondrial electron transport chain uncoupling processes, all three are intimately tied into processes associated with darkness.Say, the dark of night and the dark of hibernation. And TRPV 1 is a conduit nerve type for transmitting light based phenomena, or more accurately sunlight based phenomena such as heat sensations along with implications for darkness like sensations. The nerve has to have a wide range of tuning, to carry such sensory phenomena derived of light, with, varying degrees, along its body. And yet, at Toronto Sick Children’s Hospital, the researchers in Decewmber 2006 announced they cured diabetes 1 and effectively eradicated insulin resistance to a heavy degree in diabetes II, with capsaicin and substance P treatments. All this by treating the TRPV 1 neuron. (End Part 1- go to adjacent article on ADHD for part 2, commentary section.)

This is very hot information. I’ll share it on Delicious.