The ground-breaking STAR*D study results published last year illustrated how the majority of people who take an antidepressant actually continue to have significant depressive symptoms. These results were surprising to some, but not me.

Why? Because back in 2002, folks like Irving Kirsch, Ph.D. and David Antonuccio, Ph.D. were already pointing out how much antidepressant research doesn’t show significant clinical effects over placebo, or a sugar pill (the counterpoint argument should also be read for balance). The first article discusses how much research shows that people taking the sugar pill experienced only a 2-point difference on the depression test they used. While statistically significant, 2 points has virtually no clinical significance. That is, a person who scores 26 versus 28 really doesn’t feel any less depressed.

Researchers with a critical eye have long held that many clinical trials have significant flaws that make their results less than compelling.

The one positive that came out of the STAR*D studies are that people who kept trying different antidepressants eventually did find relief from depression symptoms. This is important information — that individuals need to work with their psychiatrist or doctor to find not only the right dose level for them, but also the right medication. It is a completely trial-and-error process. So be certain to talk regularly to your prescribing professional and let them know if your medications aren’t working.

Dr. John Grohol is the CEO and founder of Psych Central. He is an author, researcher and expert in mental health online, and has been writing about online behavior, mental health and psychology issues -- as well as the intersection of technology and human behavior -- since 1992. Dr. Grohol sits on the editorial board of the journal Cyberpsychology, Behavior and Social Networking and is a founding board member and treasurer of the Society for Participatory Medicine.

Like this author?
Catch up on other posts by John M. Grohol, PsyD (or subscribe to their feed).

Comments

This post currently has 4 comments. You can read the comments or leave your own thoughts on our new comments page.

Trackbacks

No trackbacks yet to this post.

    Last reviewed: By John M. Grohol, Psy.D. on 5 Feb 2007
    Published on PsychCentral.com. All rights reserved.