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Paxil Violence Risk in Context: Rare

By John M. Grohol, Psy.D.
September 12, 2006

Can antidepressants cause a small increased risk of violence in some people? For a small percentage of people taking Paxil (paroxetine), the answer appears to be “yes.” But the risk remains very rare.

According to a paper published today in PLoS-Medicine, there is an increased risk of “hostile” episodes while taking Paxil. The overall risk, however, remains infinitesimally small and these episodes are characterized as rare.

The researchers also had no information as to what actually may cause the increase in “hostile” episodes. Many antidepressants give people increased energy levels (while placebos do not). Such an increase in energy levels may be the actual cause in the rise of “hostile” episodes, not the drug itself.

None of this stopped at least one news organization (Reuters) from spinning the results. They only mentioned that the overall risk remains rare in the third-to-last paragraph, and instead used the opportunity to link antidepressants to an increased risk of suicide (without putting that finding into any context either). Way to go, Reuters.

3 Votes | Average: 4.33 out of 53 Votes | Average: 4.33 out of 53 Votes | Average: 4.33 out of 53 Votes | Average: 4.33 out of 53 Votes | Average: 4.33 out of 5 (3 votes, average: 4.33 out of 5)
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This entry was posted on Tuesday, September 12th, 2006 at 9:18 am and is filed under General, Policy and Advocacy, Medications, Disorders, Depression, Antidepressant, Research. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.

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Last reviewed:
  On September 12, 2006
  By John M. Grohol, Psy.D.



Understanding is the soil in which grow all the fruits of friendship.
-- Woodrow Wilson