Comments on: Birth Defects From Valproate http://psychcentral.com/blog/archives/2006/08/17/birth-defects-from-valproate/ Dr. John Grohol's daily update on all things in psychology and mental health. Since 1999. Fri, 25 May 2012 15:58:44 +0000 hourly 1 By: Female Hormones, Reward, and Mood - World of Psychology http://psychcentral.com/blog/archives/2006/08/17/birth-defects-from-valproate/comment-page-1/#comment-171108 Female Hormones, Reward, and Mood - World of Psychology Mon, 12 Feb 2007 17:30:20 +0000 http://psychcentral.com/blog/?p=1016#comment-171108 [...] Other studies indicate similar results in treatment with lithium and valproate/Depakote (though valproate has a risk of polycystic ovary syndrome, and a high risk of birth defects, so should be used with caution in reproductive-aged women). Women who experience PMDD may find relief with sertraline (Zoloft), an established first-line treatment, though in bipolar disorders monotherapy with an antidepressant is not recommended due to the risk of triggering mania. [...] [...] Other studies indicate similar results in treatment with lithium and valproate/Depakote (though valproate has a risk of polycystic ovary syndrome, and a high risk of birth defects, so should be used with caution in reproductive-aged women). Women who experience PMDD may find relief with sertraline (Zoloft), an established first-line treatment, though in bipolar disorders monotherapy with an antidepressant is not recommended due to the risk of triggering mania. [...]

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